Home Medicine Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
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Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats

  • Mahdi Abdollahi-Karizno , Hamed Aramjoo , Babak Roshanravan , Mehran Hosseini ORCID logo , Asghar Zarban and Mohsen Naseri EMAIL logo
Published/Copyright: August 6, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 19 Issue 2

Abstract

Objectives

Teucrium polium (TP) has been traditionally used for treatment of the diabetes mellitus, kidney and liver diseases, and inflammations but some studies have reported the hepatotoxicity effects of this plant. Therefore, this study was conducted to investigate the effect of TP aqueous extract on the liver of the diabetic rats.

Methods

Adult male Wistar rats were randomly divided into five groups: (Control) Normal rats that were gavaged with normal saline (1 mL), (TP100) Normal rats (Non-diabetic) that were gavaged with TP (100 mg/kg), (DM) diabetic model rats, which became diabetic by intraperitoneal injection of streptozotocin (50 mg/kg), (DTP100) diabetic rats that were gavaged with TP (100 mg/kg), and (DTP200) diabetic rats that were gavaged with TP (200 mg/kg). The effects of the aqueous extract on the blood glucose, body weight, the activities of enzyme markers of liver damage (Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)) were investigated in the serum of the control and treated groups. At the end of study liver histopathology and the total antioxidant activity (TAA) test were evaluated. Finally, obtained data were analyzed by the SPSS software (version 16).

Results

Results showed that the AST and ALT levels were significantly increased in the diabetic rats (p<0.001). A comparison of 100 mg/kg and 200 mg/kg doses of TP administration in diabetic rats also showed a significant difference (p=0.01), indicating a better performance of 100 mg/kg dose. No significant difference was found between the control group and rats treated by the TP (TP100) (p=0.382). Also, triglyceride (TG) and cholesterol levels were significantly decreased in the treated groups compared to the diabetic untreated group.

Conclusions

Findings of the study revealed no hepatotoxicity, and the hepatoprotective effects of the TP were proved in the present study.

Keywords: hepatotoxicity; liver function; streptozotocin; Teucrium polium
Corresponding author: Mohsen Naseri, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Ghaffari Street, Birjand, Southern Khorasan, Iran, Phone: +985632395450, Fax: +985632381119, E-mail:

Funding source: Birjand University of Medical Sciences

  1. Research funding: The authors would like to thank the Deputy of Research and Technology of Birjand University of Medical Sciences for financially supporting the current study.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors declared no conflict of interests.

  4. Informed consent: Not applicable.

  5. Ethical approval: Animal experimentation was approved by the Ethics Committee at Birjand University of Medical Sciences (Ethics code: Ir.bums.REC.1395.122).

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jcim-2020-0094).

Received: 2020-04-18
Accepted: 2021-07-09
Published Online: 2021-08-06

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2020-0094
Keywords for this article
hepatotoxicity; liver function; streptozotocin; Teucrium polium

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
  26. Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats
  27. Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
  29. Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls
  30. Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics
  31. Mizaj assessment in multiple sclerosis patients based on Persian Medicine
  32. Immediate effects of the practise of Sheethali pranayama on heart rate and blood pressure parameters in healthy volunteers
  33. Effects of 12 sessions of steam bath intervention on spirometry parameters among healthy adult volunteers
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  36. Effect of whole-body vibration after a resistance exercise bout on heart rate variability in hypertensive population
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  44. Case Reports
  45. Management of psoriasis with Ayurveda Panchakarma and Manibhadragula as Shodhana Rasayana – a case report
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  48. Tongue stretching: technique and clinical proposal
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