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Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls

  • Sahar A. El-Masry ORCID logo EMAIL logo , Rehab A. Mahmoud , Hanaa H. Ahmed , Muhammad Al-Tohamy , Hend M. Abdel Latif and Mahmoud A.S. Afify
Published/Copyright: June 9, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 19 Issue 2

Abstract

Objectives

Evaluate the association between overweight/obesity with serum gonadotropin and androgen levels in Egyptian pubertal girls.

Methods

A case-control study carried out in “Obesity Clinic” of “Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU)”, Pediatric Hospital, Cairo University. It included 40 overweight and obese girls and 40 age-matching normal weight (control) ones, aged 12–18 years. Anthropometric assessment (weight, height and hip and waist circumferences) was done, and waist/hip and BMI were calculated. Laboratory investigations: lipid profile, serum gonadotropin (LH, FSH), androgen (free and total testosterone), estradiol, insulin, and FBG were quantified, while insulin resistance (IR) was calculated.

Results

Hypogonadotropins (FSH and LH) and hyperandrogenaemia (total and free testosterone) were significantly prominent among obese girls. Correlation between gonadotropin, androgen and all of the studied variables, for the three studied groups (obese, overweight and control) revealed constant relations. Gonadotropin and androgens showed opposing correlations. Gonadotropin had significant negative correlations with the anthropometric parameters of obesity (BMI, waist, and W/H ratio), insulin, insulin resistance and lipid profile (triglycerides, total cholesterol and LDL), whereas androgens had significant positive ones. In addition, gonadotropin showed significant positive correlations with estradiol and HDL, while androgens showed significant negative ones.

Conclusions

Overweight/obesity had no effect on the correlations between gonadotropin and androgen on one side, with the anthropometric measurements and laboratory investigations on the other one. Alterations in androgen levels occur at earlier ages than gonadotropin, among both overweight and obese girls.

Keywords: androgens; anthropometry; Egyptian girls; gonadotropin; lipid profile; overweight/obesity
Corresponding author: Prof. Sahar A. El-Masry, Biological Anthropology Department, National Research Centre, Giza, Egypt, E-mail:

Acknowledgments

We would like to acknowledge our institute “National Research Centre; Egypt”; without its fund this study could not be done. Also, we would like to acknowledge the participant girls, the laboratory technicians and the doctors, without their help this study couldn’t have been completed.

  1. Research funding: None declared.

  2. Author contributions: Sahar A. El-Masry and Rehab A. Mahmoud: conceived and designed the study. Sahar A. El-Masry: data analysis and interpretation. Hanaa H. Ahmed: laboratory assessments. Muhammad Al-Tohamy and Hend M. Abdel Latif participatedin: data and references collection. Mahmoud A.S. Afify data collection. All authors contributed to the collection of references, drafting of the article and final approval of the submitted version. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The authors declare no financial or personal relationships with other people or organizations that could inappropriately influence the present work.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Ethical approval was obtained from the Ethics Committee of the “National Research Centre” (Approval No. 14/137). After explaining the aim of the study and its possible benefits in identifying the impact of obesity on health, a verbal approval was taken from every participant girl, in addition to a written informed consent from one of her parents.

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Received: 2020-07-12
Accepted: 2021-05-26
Published Online: 2021-06-09

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2020-0260
Keywords for this article
androgens; anthropometry; Egyptian girls; gonadotropin; lipid profile; overweight/obesity

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Swarna Prashana – faith in the embrace of research
  4. A review on the concept of aging in Ayurveda literature
  5. Ethno-pharmacology of Asaroon (Asarum europaeum L.) with special reference to Unani System of Medicine
  6. Is Trikatu an ayurvedic formulation effective for the management of flu-like illness? A narrative review
  7. The anti-cancer properties of neem (Azadirachta indica) through its antioxidant activity in the liver: its pharmaceutics and toxic dosage forms. A literature review
  8. The role of acupuncture for myofascial pain syndrome (MPS) in interventional pain management
  9. Research Articles
  10. Identification of phenolic compounds in the buds of Algerian Pistacia atlantica desf. Subsp. atlantica by antioxidant activity guided fractionation
  11. Optimization of water-based ultrasonic-microwave assisted extraction (UMAE) of bioactive compounds from Garcinia mangostana pericarp
  12. Proximate analysis, HPTLC finger print analysis and multi spectrometric analysis of Strychnos nux-vomica nuts
  13. Amelioration of sodium fluoride induced oxidative stress by Cynometra travancorica Bedd in mice
  14. The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements
  15. Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice
  16. Interaction between properties of commercial Australian honey and saliva: in vitro exploratory study of a potential mechanism in the treatment of oral mucositis
  17. The potential of immature poken (Citrus reticulata) extract in the weight management, lipid and glucose metabolism
  18. Effect of the beta-adrenergic blockade on intestinal lactate production and glycogen concentration in dogs infused with hexoses
  19. Investigating the effect of the Teucrium polium aqueous extract on the liver of the streptozotocin-induced diabetic rats
  20. Synergistic effects of high-intensity interval training (HIIT) and intake of nettle on serum levels of chemerin and beta cells function in type 2 diabetic rats
  21. The effect of Cinnamomum cassia extract on oxidative stress in the liver and kidney of STZ-induced diabetic rats
  22. Protective role of Sterculia tragacantha aqueous extract on pancreatic gene expression and oxidative stress parameters in streptozotocin-induced diabetic rats
  23. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats
  24. Amelioration of related complications by the combined usage of Gymnadenia orchidis Lindl and pumpkin seed in type 2 diabetic mice
  25. The effect of Madhumeha Kusumakar Rasa – an Ayurved medicine – in insulin resistance
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  28. Preventing SARS-CoV-2 transmission in the emergency department by implementing a separate pathway for patients with respiratory conditions
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