Home The crystal structure of (R)-2-aminobutanamide hydrochloride, C4H11ClN2O
Article Open Access

The crystal structure of (R)-2-aminobutanamide hydrochloride, C4H11ClN2O

  • Fengfeng Wang ORCID logo , Lin Luan , Youyou Wang , Xiaowen Hu ORCID logo , Caiyu Zhang ORCID logo and Yang Liu ORCID logo EMAIL logo
Published/Copyright: March 7, 2025

Abstract

C4H11ClN2O, orthorhombic, P212121 (no. 19), a = 4.9699(1) Å, b = 7.5867(2) Å, c = 17.3719(4) Å, V = 655.01(3) Å3, Z = 4, R gt (F) = 0.0286, wR ref (F2) = 0.0796, T = 200 K.

CCDC no.: 2411364

Table 1 contains the crystallographic data. The list of the atoms including atomic coordinates and displacement parameters.

Table 1:

Data collection and handling.

Crystal: Colourless block
Size: 0.20 × 0.15 × 0.12 mm
Wavelength: CuKα radiation (1.54178 Å)
μ: 4.43 mm−1
Diffractometer, scan mode: Rigaku Synergy, ω scans
θmax, completeness: 75.4°, 100 %
N (hkl)measured, N(hkl)unique, Rint: 2,585, 1,307, 0.022
Criterion for Iobs, N(hkl)gt: Iobs > 2 σ(Iobs), 1,289
N(param)refined: 89
Programs: CrysAlisPRO 1 Olex2, 2 SHELX 3 , 4

1 Source of materials

The compound was obtained commercially (Sigma–Aldrich). Crystals suitable for the diffraction test were taken directly from the provided product.

2 Experimental details

The positions of hydrogen atoms on carbon atoms were calculated geometrically and refined using the riding model. All the hydrogen atoms on nitrogen atoms were located from difference Fourier map and refined with Uiso(H) = 1.5Ueq(N). The distance between the hydrogen atoms and the nitrogen atoms were refined freely. A DFIX restrain was used to get a better model for the hydrogen atoms. The absolute structure was established by refinement of the Flack parameter (0.016(12) from 489 selected quotients) using Parsons’ method. 5

3 Comment

The title compound can be used for the synthesis of levetiracetam, 6 and brivaracetam. 7 Despite an extensive search through the Cambridge Structural Database, no reports on the single crystal structure of title compound were identified. The structural analogue, 2-aminobutanoic acid was reported as nitrate, 8 and dihydrogen phosphate. 9 , 10 , 11

The title compound crystallized in P212121 space group with one 2-aminobutanamide cation and one chloride anion in its asymmetric unit, forming a 1:1 organic salt. All bond lengths fall in the normal range. The carbon chain exhibits a typical zig-zag-like conformation. The twist angle between C1–C2–C3–C4 is 178.04 (18)°, suggesting that above atoms are nearly coplanar. Protonated amino groups establish hydrogen bonds with two chloride ions and an amide group nearby. H1A atom on the terminal amide group also engages in hydrogen bonding with a chloride ion, characterized by a DA distance of 3.250 (2) Å.


Corresponding author: Yang Liu, Institute for Chemical Drug Control, National Institutes for Food and Drug Control, Beijing, 100050 P.R. China, E-mail:

  1. Conflict of interest: The authors declare no conflicts of interest regarding this article.

  2. Research funding: Institue Building Project Of NIFDC (No.2024HYZX39).

  3. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

References

1. Rigaku Oxford Diffraction. CrysAlisPRO Software System, Version 1.171.42.92a.; Rigaku Corporation: Oxford, UK, 2023.Search in Google Scholar

2. Dolomanov, O. V.; Bourhis, L. J.; Gildea, R. J.; Howard, J. A. K.; Puschmann, H. OLEX2: a Complete Structure Solution, Refinement and Analysis Program. J. Appl. Crystallogr. 2009, 42, 339–341; https://doi.org/10.1107/s0021889808042726.Search in Google Scholar

3. Sheldrick, G. M. Crystal Structure Refinement with SHELXL. Acta Crystallogr. 2015, C71, 3–8; https://doi.org/10.1107/s2053229614024218.Search in Google Scholar

4. Sheldrick, G. M. SHELXT – Integrated Space-Group and Crystal-Structure Determination. Acta Crystallogr. 2015, A71, 3–8; https://doi.org/10.1107/s2053273314026370.Search in Google Scholar PubMed PubMed Central

5. Parsons, S.; Flack, H. D.; Wagner, T. Use of Intensity Quotients and Differences in Absolute Structure Refinement. Acta Crystallogr. 2013, B69, 249–259; https://doi.org/10.1107/s2052519213010014.Search in Google Scholar PubMed PubMed Central

6. Domingo Sanchez, J.; Gómez-Carpintero, J.; González, J. F.; Menéndez, J. C. Twenty-first Century Antiepileptic Drugs. An Overview of Their Targets and Synthetic Approaches. Eur. J. Med. Chem. 2024, 272, 116476; https://doi.org/10.1016/j.ejmech.2024.116476.Search in Google Scholar PubMed

7. Manoj, G.; Hanuman, N.; Gyanchander, E.; Bhosale, R. S.; Yadav, J. S. Synthetic Approaches toward the Synthesis of Brivaracetam: An Antiepileptic Drug. ACS Omega 2022, 7, 2486–2503; https://doi.org/10.1021/acsomega.1c05378.Search in Google Scholar PubMed PubMed Central

8. Messai, A.; Benali-Cherif, R.; Jeanneau, E.; Benali-Cherif, N. Hydrogen Bonding in 1-carboxypropanaminium Nitrate. Acta Crystallogr. Sect. E 2012, 68, o1307–o1308; https://doi.org/10.1107/s1600536812013682.Search in Google Scholar PubMed PubMed Central

9. Benali-Cherif, N.; Bendheif, L.; Merazig, H.; Bouchouit, K.; Cherouana, A. Chemical Preparation, Spectroscopic Study and Crystal Structure of DL 2–Ammoniumbutyric Dihydrogenmonophosphate. Phosphorus, Sulfur Silicon Relat. Elem. 2002, 177, 411–421; https://doi.org/10.1080/10426500210242.Search in Google Scholar

10. Kolev, T.; Spiteller, M.; Sheldrick, W. S.; Mayer–Figge, H. Acta Crystallogr., Sect. C: Crys. Struct. Commun. 2006, 62, o299; https://doi.org/10.1107/S0108270106012108.Search in Google Scholar PubMed

11. In, Y.; Fujii, M.; Sasada, Y.; Ishida, T. Acta Crystallogr. 2001, 57, 72; https://doi.org/10.1107/S0108768100013975.Search in Google Scholar

Received: 2025-01-22
Accepted: 2025-02-17
Published Online: 2025-03-07
Published in Print: 2025-06-26

© 2025 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

Articles in the same Issue

  1. Frontmatter
  2. New Crystal Structures
  3. Crystal structure of 5,5′-bis(2,4,6-trinitrophenyl)-2,2′-bi(1,3,4-oxadiazole), C16H4N10O14
  4. Crystal structure of catena-poly[(μ3-4,4′-oxydibenzoato- κ5 O,O: O,O:O)-bis(2,4,6-tri(3-pyridine)-1,3,5-triazine-κ1 N)cadmium(II)], C50H32CdN12O5
  5. The crystal structure of 1,4-diazepane-1,4-diium potassium trinitrate, C5H14KN5O9
  6. The crystal structure of benzyl 2,2,5,5-tetramethylthiazolidine-4-carboxylate, C15H21NO2S
  7. Crystal structure of 2-hydroxyethyl-triphenylphosphonium tetracyanidoborate, C24H20BN4OP
  8. The crystal structure of 1-methyl-3-(N-methylnitrous amide–N-methylene) imidazolidine-2,4,5-trione
  9. Crystal structure of N-((3-cyano-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-(2,2,2-trifluoroacetyl)-1H-pyrazol-5-yl)carbamoyl)-2,6-difluorobenzamide, C20H7Cl2F8N5O3S
  10. Crystal structure of 5-(2,2-difluoropropyl)-5-methylbenzo[4,5]imidazo[2,1-a] isoquinolin-6(5H)-one, C20H18F2N2O
  11. The crystal structure of N′,N″-[1,2-bis(4-chlorophenyl)ethane-1,2-diylidene]bis(furan-2- carbohydrazide), C24H16Cl2N4O4
  12. Crystal structure of [(4-bromobenzyl)triphenylphosphonium] tetrabromoantimony(III), [C25H21BrP]+[SbBr4]
  13. Crystal structure of [(4-bromobenzyl)triphenylphosphonium] tetrabromidoindium(III), [C25H21BrP]+[InBr4]
  14. The crystal structure of 4-carboxy-2-oxobutan-1-aminium chloride, C5H10ClNO3
  15. Crystal structure of (4-(4-chlorophenyl)-1H-pyrrole-3-carbonyl)ferrocene, C21H16ClFeNO
  16. The crystal structure of dichlorido(η6-p-cymene)(triphenylarsine)ruthenium(II), C28H29AsCl2Ru
  17. Crystal structure of (Z)-2-hydroxy-N′-(1-(o-tolyl)ethylidene)benzohydrazide, C16H16N2O2
  18. The crystal structure of 10-(1-bromoethyl)-14-(bromomethyl)dibenzo[a, c]acridine, C24H17NBr2
  19. Synthesis and crystal structure of 6-methoxy-7-[(4-methoxyphenyl)methoxy]-2H-1-benzopyran-2-one, C18H16O5
  20. Synthesis and crystal structure of ethyl 4-((4-trifluoromethylbenzyl)amino)benzo, C17H16F3NO2
  21. The crystal structure of (Z)-2-(tert-butyl)-6-(7-(tert-butyl)-5-methylbenzo[d][1,3]oxathiol-2-ylidene)-4-methylcyclohexa-2,4-dien-1-one, C23H28O2S
  22. The crystal structure of (R)-2-aminobutanamide hydrochloride, C4H11ClN2O
  23. Crystal structure of bromido[hydridotris(3-tert-butyl-5-isopropylpyrazolyl)borato-κ3 N,N′,N″]copper(II), C30H52BBrCuN6
  24. Crystal structure of chlorido{hydridotris[3-mesityl-5-methyl-1H-pyrazol-1-yl-κN3]borato}-copper(II) dichloromethane monosolvate
  25. Crystal structure of 4-[3,5-bis(propan-2-yl)-1H-pyrazol-4-yl]pyridine, C14H19N3
  26. Crystal structure of ((4-(4-bromophenyl)-1H-pyrrol-3-yl)methyl)ferrocene, C21H16BrFeNO
  27. Crystal structure of [(4-chlorobenzyl)triphenylphosphonium] dichloridocopper(I), {[C25H21ClP]+[CuCl2]}n
  28. The crystal structure of {Cu(2,9-diisopropyl-4,7-diphenyl-1,10-phenanthroline)[4,5-bis(diphenylphosphino)-9,9-dimethylxanthene]}+ PF6·1.5(EtOAC)
  29. Crystal structure of 3,5-bis(t-butyl)-1H-pyrazol-4-amine, C11H21N3
  30. Crystal structure of [(2,4-dichlorobenzyl)triphenylphosphonium] trichloridocopper(II), [C25H20Cl2P]+[CuCl3]
  31. The crystal structure of dipotassium sulfide, K2S
  32. Crystal structure of (4-(4-methoxyphenyl)-1H-pyrrole-3-carbonyl)ferrocene, C22H19FeNO2
  33. Crystal structure of (E)-6-(4-methylpiperazin-1-yl)-2-(4-(trifluoromethyl)benzylidene)-3, 4-dihydronaphthalen-1(2H)-one, C23H23F3N2O
  34. Crystal structure of (E)-6-morpholino-2-(4-(trifluoromethyl)benzylidene)-3,4-dihydronaphthalen-1(2H)-one, C22H20F3NO2
  35. Crystal structure of Ce9Ir37Ge25
  36. The crystal structure of ethyl 6-(2-nitrophenyl)imidazo[2,1-b]thiazole-3-carboxylate, C14H11N3O4S
  37. Crystal structure of (4-(4-isopropylphenyl)-1H-pyrrol-3-yl)(ferrocenyl)methanone, C24H23FeNO
  38. Crystal structure of bis(methylammonium) tetrathiotungstate(VI), (CH3NH3)2[WS4]
  39. Crystal structure of 6,11-dihydro-12H-benzo[e]indeno[1,2-b]oxepin-12-one, C17H12O2
  40. Crystal structure of 3-[(4-phenylpiperidin-1-yl)methyl]-5-(thiophen-2-yl)-2,3-dihydro-1,3,4- oxadiazole-2-thione, C18H19N3OS2
  41. Crystal structure of N-isopropyl-1,8-naphthalimide C15H13NO2
  42. TiNiSi-type EuPdBi
  43. Crystal structure of 1-(p-tolylphenyl)-4-(2-thienoyl)-3-methyl-1H-pyrazol-5-ol, C16H14N2O2S
  44. The crystal structure of 3-(3-carboxypropyl)-2-nitro-1H-pyrrole 1-oxide, C7H9N3O5
  45. The crystal structure of tetraaqua-bis(2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetato-k2O:N)-tetrakis(2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetato-k1N)trizinc(II) hexahydrate C36H52N18O32Zn3
  46. The crystal structure of 4-(3-carboxy-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ium 4-hydroxy-3,5-dimethoxybenzoate monohydrate, C25H30FN3O9
  47. Crystal structure of bis(DL-1-carboxy-2-(1H-indol-3-yl)ethan-1-aminium) oxalate — acetic acid (1/2)
  48. Crystal structure of methyl (E)-4-((4-methylphenyl)sulfonamido)but-2-enoate, C12H15NO4S
  49. The crystal structure of actarit, C10H11NO3
  50. The crystal structure of bicyclol, C19H18O9
  51. The crystal structure of topiroxostat, C13H8N6
  52. Crystal structure of 2,2-dichloro-N-methyl-N-(4-p-tolylthiazol-2-yl)acetamide, C13H12Cl2N2OS
  53. Crystal structure of 4-(trifluoromethyl)-7-coumarinyl trifluoromethanesulfonate C11H4F6O5S
  54. Crystal structure of (1,4,7,10,13,16-hexaoxacyclooctadecane-κ6O6)-((Z)-N,N′-bis(2-(dimethylamino)phenyl)carbamimidato-κ1N)potassium(I)
  55. Crystal structure of (Z)-2-(5-((4-(dimethylamino)naphthalen-1-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid, C18H16N2O3S2
  56. Crystal structure of (4-fluorobenzyl)triphenylphosphonium bromide, C25H21BrFP
  57. The crystal structure of dichlorido-[6-(pyridin-2-yl)phenanthridine-κ2N, N′]zinc(II)-chloroform (1/1), C19H13N2ZnCl5
  58. Crystal structure of (E)-(3-(2,4-dichlorophenyl)acryloyl)ferrocene, C19H14Cl2FeO
  59. The crystal structure of (E)-7-chloro-1-cyclopropyl-6-fluoro-3-((2-hydroxybenzylidene)amino)quinolin-4(1H)-one, C19H14ClFN2O2
  60. Crystal structure of 2-bromo-11-(((fluoromethyl)sulfonyl)methyl)-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide, C16H13BrFNO4S2
  61. Crystal structure of 2-chloro-11-(((fluoromethyl)sulfonyl)methyl)-6-methyl-6,11-dihydrodibenzo[c,f][1,2]thiazepine 5,5-dioxide, C16H13ClFNO4S2
  62. Crystal structure of 5-(2,2-difluoropropyl)-5-methyl-6-oxo-5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline-3-carbonitrile, C20H15F2N3O
Downloaded on 13.10.2025 from https://www.degruyterbrill.com/document/doi/10.1515/ncrs-2025-0044/html?srsltid=AfmBOoqi_mYbrQ9DR_dDgS7xG9gxHVE8nlbeWODLUHyApSWriWK2xKjI
Scroll to top button