Home Synthesis and crystal structure of methyl 2-{[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazole-3-yl]thio} acetate, C18H17N3O2S
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Synthesis and crystal structure of methyl 2-{[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazole-3-yl]thio} acetate, C18H17N3O2S

  • Yuan Xian-Zhu , Zhang Ding-Wa , Yi Xiu-Guang EMAIL logo , Zeng Hui-Lei and Yi Zhi-Qiang ORCID logo EMAIL logo
Published/Copyright: April 4, 2024
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Zeitschrift für Kristallographie - New Crystal Structures
From the journal Zeitschrift für Kristallographie - New Crystal Structures Volume 239 Issue 3

Abstract

C18H17N3O2S, monoclinic, P21/c (no. 14), a = 10.9713(5) Å, b = 15.4445(8) Å, c = 9.8221(4) Å, β = 98.275(4)°, V = 1646.99(13) Å3, Z = 4, Rgt (F) = 0.0401, wRref (F 2) = 0.0990, T = 296(2) K.

CCDC no.: 2341009

Table 1 contains crystallographic data and Table 2 contains the list of the atoms including atomic coordinates and displacement parameters.

Table 1:

Data collection and handling.

Crystal: Yellow block
Size: 0.23 × 0.17 × 0.14 mm
Wavelength: Mo Kα radiation (0.71073 Å)
μ: 0.21 mm−1
Diffractometer, scan mode: D8/APEX2, φ and ω
θ max, completeness: 25.0°, >99 %
N(hkl)measured, N(hkl)unique, R int: 9313, 2906, 0.019
Criterion for I obs, N(hkl)gt: I obs > 2σ(I obs), 2430
N(param)refined: 226
Programs: Bruker [1], SHELX [2, 3], Diamond [4]
Table 2:

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2).

Atom x y z U iso*/U eq
C1 1.1379 (2) 0.1369 (2) 1.5252 (3) 0.0835 (9)
H1A 1.1233 0.1180 1.6145 0.125*
H1B 1.1824 0.0930 1.4838 0.125*
H1C 1.1853 0.1894 1.5342 0.125*
C2 1.0259 (2) 0.17954 (14) 1.3117 (2) 0.0481 (5)
C3 0.8980 (2) 0.2046 (2) 1.2460 (2) 0.0571 (6)
C4 0.85857 (17) 0.07197 (13) 1.06705 (18) 0.0389 (4)
C5 0.83748 (17) −0.05848 (13) 0.9907 (2) 0.0430 (5)
H5 0.8198 −0.1059 0.9329 0.052*
C6 0.75820 (16) 0.05789 (12) 0.82003 (18) 0.0349 (4)
C7 0.63682 (15) 0.09122 (11) 0.81232 (17) 0.0322 (4)
C8 0.56984 (17) 0.08977 (12) 0.92520 (19) 0.0396 (5)
H8 0.6058 0.0666 1.0088 0.048*
C9 0.45342 (18) 0.12197 (14) 0.9127 (2) 0.0470 (5)
H9 0.4103 0.1200 0.9876 0.056*
C10 0.39791 (18) 0.15789 (14) 0.7888 (2) 0.0500 (5)
H10 0.3188 0.1807 0.7822 0.060*
C11 0.45914 (17) 0.15966 (13) 0.6774 (2) 0.0432 (5)
H11 0.4212 0.1838 0.5954 0.052*
C12 0.57983 (16) 0.12522 (11) 0.68472 (18) 0.0342 (4)
C13 0.64333 (16) 0.12171 (11) 0.56667 (18) 0.0349 (4)
C14 0.75834 (17) 0.08656 (13) 0.58105 (19) 0.0417 (5)
H14 0.7990 0.0834 0.5044 0.050*
C15 0.81785 (17) 0.05486 (13) 0.70790 (19) 0.0414 (5)
H15 0.8970 0.0321 0.7149 0.050*
C16 0.58272 (18) 0.15701 (13) 0.43202 (18) 0.0414 (5)
H16 0.5770 0.2203 0.4283 0.050*
C17 0.4766 (2) 0.11063 (16) 0.3497 (2) 0.0597 (6)
H17A 0.4519 0.0554 0.3840 0.072*
H17B 0.4098 0.1454 0.3029 0.072*
C18 0.5974 (2) 0.11506 (18) 0.2987 (2) 0.0682 (7)
H18A 0.6040 0.1524 0.2207 0.082*
H18B 0.6461 0.0625 0.3019 0.082*
H3A 0.834 (2) 0.1770 (16) 1.292 (2) 0.071 (8)*
H3B 0.894 (2) 0.2632 (18) 1.252 (3) 0.075 (8)*
N1 0.88388 (15) −0.06394 (12) 1.11983 (18) 0.0506 (5)
N2 0.89793 (15) 0.02069 (12) 1.16988 (16) 0.0467 (4)
N3 0.81796 (13) 0.02530 (10) 0.95072 (15) 0.0373 (4)
O1 1.11751 (16) 0.18538 (12) 1.26099 (17) 0.0684 (5)
O2 1.02109 (14) 0.15273 (11) 1.43938 (14) 0.0606 (4)
S1 0.86185 (6) 0.18445 (4) 1.06464 (5) 0.0578 (2)

1 Source of materials

Intermediate 4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (45.0 g, 0.169 mol) and triethylamine (18.7 g, 0.183 mol) of were added into absolute ethanol (400 mL) at room temperature. Cooling to 0 °C, dropping 150 mL of absolute ethanol solution of ethyl bromoacetate (29.6 g, 0.18 mol), and controlling the temperature to 0 °C for 1 h after dropping. Most of the solvent was evaporated under reduced pressure, and the reaction solution was poured into 250 mL of water, extracted with dichloromethane (100 mL × 3), and the organic layers were combined. Wash with 200 mL water and 200 mL saturated sodium chloride solution, and dry the organic layer with anhydrous sodium sulfate. 52.4 g yellow oil product was obtained with a yield of 88.2 %.

2 Experimental details

All H atoms were included in calculated positions and refined as riding atoms, with C–H = 0.90–0.97 Å with U iso(H) = 1.5 U eq(C) for methyl H atoms and 1.2 U eq(C) for all other H atoms.

3 Comment

Lesinurad sodium is the first inhibitor of uric acid selective reabsorption transporter-1 (URAT1), which was first developed by Aread Biosciences and then continued to be developed by Astra Zeneca [5]. The chemical name of lesinurad sodium is 2-{[5-bromo-4-(4-cyclopropylnaphthalene-1-yl)-4h-1,2,4-triazol-3-yl]thio} acetic acid, which is mainly used for treating hyperuricemia related to gout in combination with xanthine oxidase inhibitors (such as allopurinol and febuxostat) [6], [7], [8]. Optimizing the synthesis process of lesinurad sodium and its derivatives has attracted the attention of researchers [9], [10], [11]. Recently, we have been focusing on the synthesis of esinurad sodium and optimizing its synthesis process. Here we reveal the synthesis and crystal structure of methyl 2-{[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazole-3-yl]thio} acetate, the key intermediate of lesinurad sodium.

In the molecules of the title structure bond lengths and angles are very similar to those given in the literature [12–15]. In the title structure, the dihedral angle formed by the naphthalene ring plane, the 1,2,4-triazole-3-thione plane and the cyclopropyl group plane are 54.6°, 71.5(73)° and 86.9°, respectively. These parameters are different from the data reported before [13]. The dihedral angle between the 1,2,4-triazole-3-thione plane and the ester plane to which it is connected is 89.0(213)°. The torsion angles of N2–C4–S1–C3 and C4–S1–C3–C2 are −12.798(207)° and 69.286(186)°. Intermolecular C–H⋯O hydrogen bonds and C–H⋯N hydrogen bonds connect two adjacent compounds into a dimer.

Corresponding authors: Yi Xiu-Guang, School of Chemistry and Chemical Engineering, Jinggangshan Univeristy, Ji’an, Jiangxi, 343709, P.R. China, E-mail: ; and Yi Zhi-Qiang, Ji’an Central People’s Hospital, Ji’an, Jiangxi, 343700, P.R. China, E-mail:

Funding source: National Natural Science Foundation of China

Award Identifier / Grant number: 22168018

Funding source: National Natural Science Foundation of Jiangxi, China

Award Identifier / Grant number: 20232BAB203048; 20202BABL206111

Funding source: Science and Technology Plan Project Fund of Jiangxi Provincial Health Planning Commission

Award Identifier / Grant number: 202411004

Funding source: Science and Technology Plan Project of Ji’an

Award Identifier / Grant number: 20233–043398, 20233–043995

Acknowledgment

X-ray data were collected at Instrumental Analysis Center Nanchang Hangkong University, Nanchang, 330063, People’s Republic of China.

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This research was supported by the National Natural Science Foundation of China (22168018), the National Natural Science Foundation of Jiangxi, China (20232BAB203048; 20202BABL206111), The Science and Technology Plan Project Fund of Jiangxi Provincial Health Planning Commission (202411004), the Science and Technology Plan Project of Ji’an (20233–043398, 20233–043995).

  3. Conflict of interest: The authors declare no conflicts of interest regarding this article.

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Received: 2024-02-06
Accepted: 2024-03-20
Published Online: 2024-04-04
Published in Print: 2024-06-25

© 2024 the author(s), published by De Gruyter, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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https://doi.org/10.1515/ncrs-2024-0056
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Articles in the same Issue

  1. Frontmatter
  2. New Crystal Structures
  3. The crystal structure of tris((Z)-2-hydroxy-N-((E)-pyridin-2-ylmethylene)benzohydrazonato-k2O,N)europium(III), C39H30N9O6Eu
  4. Crystal structure of (E)-3-(benzylideneamino)-2-phenylthiazolidin-4-one, C16H14N2OS
  5. The crystal structure of (E)-4-fluoro-N′-(1-(o-tolyl)ethylidene)benzohydrazide, C16H15FN2O
  6. Crystal structure of (6-chloropyridin-3-yl)methyl 2-(6-methoxynaphthalen-2-yl)propanoate, C20H18ClNO3
  7. Crystal structure of methyl 3-methoxy-4-(2-methoxy-2-oxoethoxy)benzoate, C12H14O6
  8. The crystal structure of bis[(4-methoxyphenyl)(picolinoyl)amido-κ2 N:N′]copper(II), C26H22CuN4O4
  9. The crystal structure of poly[di(μ2-aqua)-diaqua-bis(3-aminopyridine-4-carboxylate-κ2 O: O′)-tetra(μ2-3-aminopyridine-4-carboxylate-κ2 O: O′)-dineodymium(III), [Nd2(C6H5N2O2)6(H2O)4] n
  10. The crystal structure of t-butyl 7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate, C28H34FNO4
  11. Crystal structure of catena-poly[(benzylamine-κ1 N)-(sorbato-κ1 O)-(μ2-sorbato-κ2 O,O′)-copper(II), C19H23CuNO4
  12. Crystal structure of (4-(2-chlorophenyl)-1H-pyrrol-3-yl)(ferrocenyl) methanone, C21H16ClFeNO
  13. The crystal structure of N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-(2-methylphenyl)-2-sulfanylprop-2-enamide hydrate, C19H17BrN2O2S2
  14. The crystal structure of N′-{5-[2-(2,6-dimethylphenoxy) acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl}-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide hydrate
  15. Crystal structure of 2-(naphthalen-1-yl)ethyl 2-(6-methoxynaphthalen-2-yl)propanoate, C26H24O3
  16. Crystal structure of naphthalen-1-ylmethyl 2-(6-methoxynaphthalen-2-yl)propanoate, C25H22O3
  17. Crystal structure of poly[diaqua- (μ4-5-(1H-1,2,4-triazol-1-yl)benzene-1,3-dicarboxylato-κ5N:O,O’:O’’:O’’’)calcium(II), C10H9CaN3O6
  18. Crystal structure of (E)-N′-(4-((E)-3-(dimethylamino)acryloyl)-3-hydroxyphenyl)-N, N-dimethylformimidamide, C14H19N3O2
  19. Crystal structure of (E)-3-(dimethylamino)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one, C13H17NO4
  20. Crystal structure of (2-chloropyridin-3-yl)methyl-2-(6-methoxynaphthalen-2-yl)propanoate, C20H18ClNO3
  21. The crystal structure of diethyl 4-(3,4-dimethylphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, C21H27NO4
  22. Crystal structure of (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-((4-(2-phenylpropyl)phenyl)ethynyl)-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one, C36H42O2
  23. Synthesis and crystal structure of 4-(4-cyclopropylnaphthalen-1-yl)-2,4-dihydro-3H-1,2,4-triazole-3-thione, C15H13N3S
  24. Crystal structure of catena-poly[aqua-(2,6-di-(2-pyridyl)-pyridine-κ3 N,N′, N″)(μ2-1,4-naphthalene dicarboxylato-κ2 O,O′)nickel(II)], C27H19NiN3O5
  25. Crystal structure of 3-(diphenylphosphoryl)-3-hydroxy-1-phenylpropan-1-one, C21H19O3P
  26. The crystal structure of R,S-{N-[(2-oxidonaphthalen-1-yl)methylidene]phenylglycinato}divinylsilicon, C23H19NO3Si
  27. The crystal structure of 1,2,4-tris(bromomethyl)benzene, C9H9Br3
  28. Crystal structure of chlorido-[4-(pyridin-2-yl)benzaldehyde-κ2 N,C]-(diethylamine-κ1 N)platinum(II), C16H18ClN2OPt
  29. Crystal structure of 3-(methoxycarbonyl)-1-(4-methoxyphenyl)-2,3,4,9- tetrahydro-1H-pyrido[3,4-b]indol-2-ium chloride hydrate, C40H48Cl2N4O9
  30. The crystal structure of 1-(2-chlorobenzyl)-3-(3-chlorophenyl)urea, C14H12Cl2N2O
  31. Hydrothermal synthesis and crystal structure of aqua-tris(4-acetamidobenzoato-κ2 O,O′)-(1,10-phenanthroline-κ2 N,N′)terbium(III) hydrate C39H36N5O11Tb
  32. The crystal structure of zwitterionic 3-aminoisonicotinic acid, C6H6N2O2
  33. The crystal structure of bis{[monoaqua-μ2-4-[(pyridine-4-carbonyl)-amino]-phthalato-κ3 N:O,O′-(2,2′-bipyridine κ2 N,N′)copper(II)]}decahydrate, C48H56N8O22Cu2
  34. Crystal structure of poly[μ10-4,4′-methylene-bis(oxy)benzoatodipotassium], C15H10K2O6
  35. The crystal structure of catena-poly[[tetraaqua[(μ2-1,4-di(4-methyl-1-imidazolyl)benzene] cobalt(II)]bis(formate)], C16H24CoN4O8
  36. The crystal structure of (E)-2-chloro-5-((2-(nitromethylene)imidazolidin-1-yl)methyl)pyridine, C10H11ClN4O2
  37. The crystal structure of (E)-1-(((2-amino-4,5-dimethylphenyl)iminio)methyl)naphthalen-2-olate, C19H18N2O
  38. Crystal structure of N-(acridin-9-yl)-2-(4-methylpiperidin-1-yl) acetamide monohydrate, C21H25N3O2
  39. The crystal structure of dichlorido-bis(3-methyl-3-imidazolium-1-ylpropionato-κ2 O,O′)-zinc(II), C14H20Cl2N4O4Zn
  40. The crystal structure of 2,8-diethyl-1,3,7,9-tetramethyl-4λ4,5λ4-spiro[dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinine-5,2′-naphtho[1,8-de][1,3,2]dioxaborinine], C25H29BN2O2
  41. The crystal structure of 5-tert-butyl-2-(5-tert-butyl-3-iodo-benzofuran-2-yl)-3-iodobenzofuran, C24H24I2O2
  42. Synthesis and crystal structure of methyl 2-{[4-(4-cyclopropyl-1-naphthyl)-4H-1,2,4-triazole-3-yl]thio} acetate, C18H17N3O2S
  43. The crystal structure of n-propylammonium bis(2,3-dimethylbutane-2,3-diolato)borate-boric acid (1/1), [C3H10N][C12H24BO4]·B(OH)3
  44. Crystal structure of methyl 1-(2-bromophenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate, C19H17BrN2O2
  45. Crystal structure of (4-bromobenzyl)triphenylphosphonium bromide ethanol solvate, C52H48Br4OP2
  46. The crystal structure of unsymmetrical BOPHY C26H27BN4
  47. The crystal structure of Tb3B5O11(OH)2
  48. The crystal structure of (Z)-4-ethyl-2-((4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3,5-dimethyl-2H-pyrrol-1-ium 2,2'-spirobi[naphtho[1,8-de][1,3,2]dioxaborinin]-2-uide, C37H37BN2O4
  49. Crystal structure of bis(methylammonium) hexadecaselenidopalladate(II), (CH3NH3)2PdSe16
  50. The crystal structure of (2-diphenylphosphanylphenyl) 2-[7-(dimethylamino)-2-oxochromen-4-yl]acetate, C31H26NO4P
  51. Crystal structure of (E)-6-(4-ethylpiperazin-1-yl)-2-(3-fluorobenzylidene)-3,4-dihydronaphthalen-1(2H)-one, C23H25FN2O
  52. The structure of RUB-56, (C6H16N)8 [Si32O64(OH)8]·32 H2O, a hydrous layer silicate (2D-zeolite) that contains microporous levyne-type silicate layers
  53. Crystal structure of 4-amino-3,5-dibromobenzonitrile, C7H4Br2N2
  54. Crystal structure of 2-(naphthalen-1-yl)ethyl 2-acetoxybenzoate, C21H18O4
  55. Single-crystal structure determination of Tm3B12O19(OH)7
  56. Crystal structure determination of NdB3.6O7
  57. The crystal structure of NdB6O8(OH)5·H3BO3
  58. Crystal structure of 2-(5-ethylpyridin-2-yl)ethyl 2-(6-methoxynaphthalen-2-yl)propanoate, C23H25NO3
  59. Crystal structure of N-(1-(3,4-dimethoxyphenyl)-2-methylpropyl)aniline, C18H23NO2
  60. Crystal structure of Ba6Cd12Mn4SiF48
  61. Synthesis and crystal structure of 5-fluoro-1-methyl-2-oxo-3-(2-oxochroman-4-yl)indolin-3-yl acetate, C20H16FNO5
  62. The crystal structure of 6-methacryloylbenzo[d][1,3]dioxol-5-yl 4-nitrobenzenesulfonate, C17H13NO8S
  63. Crystal structure of ethyl 2-(3-benzyl-4-oxo-3,4-dihydrophthalazin-1-yl)- 2,2-difluoroacetate, C19H16F2N2O3
  64. The crystal structure of tetrakis(μ 2-(1H-benzimidazole-2-methoxo-κ2 N,O:O:O)-(n-butanol-κO)-chlorido)-tetranickel(II), C48H68Cl4N8O8Ni4
  65. Synthesis and crystal structure of trans-tetraaqua-bis((1-((7-hydroxy-3-(4-methoxy-3-sulfonatophenyl)-4-oxo-4H-chromen-8-yl)methyl)piperidin-1-ium-4-carbonyl)oxy-κO)zinc(II)hexahydrate, C46H64N2O28S2Zn
  66. The crystal structure of 1-(4-carboxybutyl)-3-methyl-1H-imidazol-3-ium hexafluoridophosphate, C9H15F6N2O2P
  67. Crystal structure of 1-(4-chlorophenyl)-4-(2-furoyl)-3-phenyl-1H-pyrazol-5-ol, C20H13ClN2O3
  68. Crystal structure of dimethyl (R)-2-(3-(1-phenylethyl)thioureido)-[1,1′-biphenyl]-4,4′-dicarboxylate, C25H24N2O4S
  69. The crystal structure of 1-(3-carboxypropyl)-1H-imidazole-3-oxide, C7H10N2O3
  70. Synthesis and crystal structure of dimethyl 4,4′-(propane-1,3-diylbis(oxy))dibenzoate, C19H20O6
  71. Crystal structure of methyl-1-(p-tolyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate, C20H20N2O2
  72. The crystal structure of 1-(1-adamantan-1-yl)ethyl-3-(3-methoxyphenyl)thiourea, C20H28N2OS
  73. The crystal structure of N,N′-carbonylbis(2,6-difluorobenzamide), C15H8F4N2O3
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