Startseite Medizin Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
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Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial

  • Chintamani Nayak EMAIL logo , Nivedita Pattanaik , Abhijit Chattopadhyay , Pankhuri Misra , Koushik Bhar , James Michael , Munmun Koley und Subhranil Saha ORCID logo
Veröffentlicht/Copyright: 20. Oktober 2020
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 18 Heft 3

Abstract

Objectives

The quality of management of hyperuricemia has remained sub-optimal owing to unavoidable toxicities, limitations, and dearth of novel advances. Homeopathy has remained under-researched in hyperuricemia. We investigated the clinical effectiveness of three treatment regimens – individualized homeopathy (IH), Urtica urens mother tincture (UUMT), and both (IH + UUMT) along with lifestyle modifications in a sample of 90 patients with hyperuricemia.

Methods

An open, randomized (1:1:1), 3 parallel arms (IH, UUMT, and IH + UUMT), pragmatic trial was conducted at National Institute of Homoeopathy, Kolkata. Outcome measures were serum uric acid (primary), Gout Assessment Questionnaire version 2 (GAQ2, secondary), and Measure Yourself Medical Outcome Profile version 2 (MYMOP2, secondary); all measured at baseline, and after 3 and 6 months. Intention- to-treat sample was analyzed to detect group differences by unpaired t tests.

Results

Attrition rate was 8.9% (IH: 3, UUMT: 3, IH + UUMT: 2). Groups were comparable at baseline. Reductions in serum uric acid over 3 months were comparatively higher (p=0.057) in the UUMT group than others, however, the differences were narrowed over 6 months (p=0.119). Per protocol analysis of serum uric acid level revealed similar trend of significantly higher reduction in the UUMT group than the other two (3 months: p=0.001; 6 months: p=0.007). No significant differences existed in reductions of GAQ2 scores among the three groups. Few significant differences were detected in MYMOP scores over 3 months favoring IH against others (symptom 2, p=0.001 and wellbeing score, p=0.002), and also over 6 months favoring IH + UUMT against others (symptom 1, p<0.001).

Conclusion

Although all three therapies showed similar improvements, the IH + UUMT group had more positive direction of effects than IH or UUMT alone; however, no definite conclusion could be arrived at. Further trials are warranted with larger sample size. Trial registration: CTRI/2018/05/014026.

Keywords: clinical trial; homeopathy; hyperuricemia; pragmatic trial; randomized controlled trial; Urtica urens
Corresponding author: Dr. Chintamani Nayak, Ph.D. Scholar, Shree Guru Gobind Singh Tricentenary University, Gurgaon, Gurugram, Haryana 122505, India; and Dept. of Materia Medica, National Institute of Homoeopathy, Ministry of AYUSH, Govt. of India, Block GE, Sector 3, Salt Lake, Kolkata 700106, West Bengal, India, E-mail:

Acknowledgment

The authors are grateful to institutional heads, both academic and hospital section for allowing us to conduct the trial. We sincerely thank the patients for their sincere participation.

  1. Research funding: None declared.

  2. Author contribution: CN, NP, AC, PM, KB, JM, MK, SS: Concept, design, literature search, data interpretation, and preparation of the article; CN, PM, KB and JM: Clinical study and data acquisition. CN: Data management and master chart preparation; MK and SS: Data interpretation, statistical analysis; PM: Preparation of the article. All the authors reviewed and approved the final article.

  3. Competing interests: The funding organization(s) has no role to play in conduct of the trial or publication of the paper.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study protocol was approved by the Institutional Ethics Committee (Ref. F. No. 5-23/NIH/PG/Ethical Comm. 2009/Vol. 5/2671 (A/S), dated April 10, 2018; Supplementary file 1) and was registered subsequently in the Clinical Trials Registry – India vide CTRI/2018/05/014026 with a secondary identifier – Universal Trial number of U1111-1214-230 (Supplementary file 2).

References

1. Billa, G, Dargad, R, Mehta, A. Prevalence of hyperuricemia in Indian subjects attending hyperuricemia screening programs: a retrospective study. J Assoc Phys India 2018;66:43–6.Suche in Google Scholar

2. Conen, D, Wietlisbach, V, Bovet, P, Shamlaye, C, Riesen, W, Paccaud, F, et al. Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Publ Health 2004;4:9. https://doi.org/10.1186/1471-2458-4-9.Suche in Google Scholar PubMed PubMed Central

3. Gliozzi, M, Malara, N, Muscoli, S, Mollace, V. The treatment of hyperuricemia. Int J Cardiol 2016;213:23–7. https://doi.org/10.1016/j.ijcard.2015.08.087.Suche in Google Scholar PubMed

4. Ralston, SH, Penman, ID, Strachan, MWJ, Hobson, RP, editors. Davidson’s principles and practice of medicine, 23rd ed. Edinburgh: Elsevier Ltd.; 2018:1360 p.Suche in Google Scholar

5. Kuo, CF, Grainge, MJ, Zhang, W, Doherty, M. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol 2015;11:649–62. https://doi.org/10.1038/nrrheum.2015.91.Suche in Google Scholar PubMed

6. Kuo, CF, Grainge, MJ, See, LC, Yu, KH, Luo, SF, Zhang, W, et al. Epidemiology and management of gout in Taiwan: a nationwide population study. Arthritis Res Ther 2015;17:13. https://doi.org/10.1186/s13075-015-0522-8.Suche in Google Scholar PubMed PubMed Central

7. Winnard, D, Wright, C, Taylor, WJ, Jackson, G, Te Karu, L, Gow, PJ, et al. National prevalence of gout derived from administrative health data in Aotearoa New Zealand. Rheumatology 2012;51:901–9. https://doi.org/10.1093/rheumatology/ker361.Suche in Google Scholar PubMed

8. Chen-Xu, M, Yokose, C, Rai, SK, Pillinger, MH, Choi, HK. Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: the national health and nutrition examination survey, 2007–2016. Arthritis Rheum 2019;71:991–9.10.1002/art.40807Suche in Google Scholar PubMed PubMed Central

9. Kuo, CF, Grainge, MJ, Mallen, C, Zhang, W, Doherty, M. Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann Rheum Dis 2015;74:661–7. https://doi.org/10.1136/annrheumdis-2013-204463.Suche in Google Scholar PubMed PubMed Central

10. Bardin, T, Bouee, S, Clearson, P, Chalès, G, Flipo, RM, Lioté, F, et al. Prevalence of gout in the adult population of France. Arthritis Care Res 2016;68:261–6. https://doi.org/10.1002/acr.22660.Suche in Google Scholar PubMed

11. Xia, Y, Wu, Q, Wang, H, Zhang, S, Jiang, Y, Gong, T, et al. Global, regional and national burden of gout, 1990–2017: a systematic analysis of the Global Burden of Disease Study. Rheumatology 2019;59:1529–38. https://doi.org/10.1093/rheumatology/kez476.Suche in Google Scholar PubMed

12. Terkeltaub, R. Novel therapies for treatment of gout and hyperuricemia. Arthritis Res Ther 2009;11:236. https://doi.org/10.1186/ar2738.Suche in Google Scholar PubMed PubMed Central

13. Beara-Lasic, L, Pillinger, MH, Goldfarb, DS. Advances in the management of gout: critical appraisal of febuxostat in the control of hyperuricemia. Int J Nephrol Renovascular Dis 2010;3:1–10.10.2147/IJNRD.S5563Suche in Google Scholar

14. Prasad, N, Gupta, A. Diagnosis and management of hyperuricemia. Hyperuricemia: a renal perspective. New Delhi: Elsevier, a division of Reed Elsevier India Private Limited; 2012.Suche in Google Scholar

15. Ahmad, M, Faraazi, AA, Aamir, MN. The effect of Ocimum sanctum and Ledum palustre on serum uric acid level in patients suffering from gouty arthritis and hyperuricemia. Bull Chem Soc Ethiop 2013;27:469–73. https://doi.org/10.4314/bcse.v27i3.16.Suche in Google Scholar

16. Cara, R, Tikly, M, Solomon, EM, Deroukakis, M. Homeopathic treatment of acute gout. Am J Homeopath Med 2007;100:40–4.Suche in Google Scholar

17. Sahani, A, Banerjee, A, Kumar, A, Kumari, S. Individualized homeopathy as an adjunct in the treatment of gout – a randomized placebo controlled trial. Allg Hom Ztg 2017;262:R07–03. https://doi.org/10.1055/s-0037-1601194.Suche in Google Scholar

18. Saha, S, Sarkar, P, Chattopadhyay, R, Saha, S. An open-label prospective observational trial for assessing the effect of homoeopathic medicines in patients suffering from gout. Indian J Res Homoeopathy 2019;13:236–43. https://doi.org/10.4103/ijrh.ijrh_48_19.Suche in Google Scholar

19. Shaffique, S, Ahmed, S, Rehman, T, Mumtaz, W, Anwar, H, Hussain, G. Anti- hyperuricemic potential of Rhododendron tomentosum Harmaja syn. Ledum palustre L. 30c and 1M in potassium oxonate induced rat model. Ind J Tradit Knowl 2018;17:724–31. http://nopr.niscair.res.in/handle/123456789/45061.Suche in Google Scholar

20. Boericke, W. New manual of homeopathic materia medica and repertory [with relationship of remedies], second re-augmented & revised edition based, 9th ed. New Delhi: B. Jain Publishers; 2002.Suche in Google Scholar

21. Riley, DS. Materia medica of new and old homeopathic medicines. USA: Springer- Verlag GmbH; 2012.10.1007/978-3-642-25292-1Suche in Google Scholar

22. Farrington, EA. Condensed materia medica by Constantine Hering, 4th ed. New Delhi: B. Jain Publishing Co.; 1978:936 p.Suche in Google Scholar

23. Varma, PN, Yadav, K, Valavan, R. A compendium of rare and clinically established mother tinctures with index of indications, 5th ed. New Delhi: Dr. Willmar Schwabe India Pvt. Ltd.; 2016:182–3 pp.Suche in Google Scholar

24. Patel, S, Biswas, B, Rambabu, K, Jhansi, S, Potu, R, Sundaram, EN, et al. Pharmacognostic and physiochemical study of Urtica urens L.: a drug used in Homeopathy. Indian J Res Homeopathy 2019;13:91–9. https://doi.org/10.4103/ijrh.ijrh_50_18.Suche in Google Scholar

25. Lapinskaya, E, Kopytko, Y, Timokhina, E, Krapivkin, B, Levandovskii, G, Dargaeva, T, et al. Amino acids and cyclic dipeptides in stinging nettle (Urtica dioica and U. urens) homeopathic matrix tinctures. Pharmaceut Chem J 2008;42:650–3. https://doi.org/10.1007/s11094-009-0189-z.10.1007/s11094-009-0189-zSuche in Google Scholar

26. Kregiel, D, Pawlikowska, E, Antolak, H. Urtica spp. : ordinary plants with extraordinary properties. Molecules 2018;23:1664. https://doi.org/10.3390/molecules23071664.Suche in Google Scholar PubMed PubMed Central

27. Taylor, WJ. Gout measures: gout assessment questionnaire (GAQ, GAQ2.0), and physical measurement of tophi. Arthritis Care Res 2011;63:S59–63. https://doi.org/10.1002/acr.20622.Suche in Google Scholar PubMed

28. Paterson, C, Britten, N. In pursuit of patient-centred outcomes: a qualitative evaluation of the ‘Measure Yourself Medical Outcome Profile’. J Health Serv Res Pol 2000;5:27–36. https://doi.org/10.1177/135581960000500108.Suche in Google Scholar PubMed

29. Pichholiya, M, Yadav, AK, Luhadia, SK, Tahashildar, J, Aseri, ML. A comparative study of efficacy and safety of febuxostat and allopurinol in pyrazinamide-induced hyperuricemic tubercular patients. Indian J Pharmacol 2016;48:522–5. https://doi.org/10.4103/0253-7613.190729.Suche in Google Scholar PubMed PubMed Central

30. Zwarenstein, M, Treweek, S, Gagnier, JJ, Altman, DG, Tunis, S, Haynes, B, et al. CONSORT group; Pragmatic Trials in Healthcare (Practihc) group. Improving the reporting of pragmatic trials: an extension of the CONSORT statement. Br Med J 2008;337:a2390. https://doi.org/10.1136/bmj.a2390.Suche in Google Scholar PubMed PubMed Central

31. Dean, ME, Coulter, MK, Fisher, P, Jobst, K, Walach, H. Reporting data on homeopathic treatments (RedHot): a supplement to CONSORT. Homeopathy 2007;96:42–5. https://doi.org/10.1016/j.homp.2006.11.006.Suche in Google Scholar PubMed

32. Manchanda, RK, Khurana, A, Fisher, P, Arya, BS, Mehra, P, Saha, S, et al. Homoeopathic drug proving researches (1996–2018): a scoping review. Indian J Res Homoeopathy 2020;14:24–49. https://doi.org/10.4103/ijrh.ijrh_32_19.Suche in Google Scholar

33. Shiovitz, TM, Bain, EE, McCann, DJ, Skolnick, P, Laughren, T, Hanina, A, et al. Mitigating the effects of non-adherence in clinical trials. J Clin Pharmacol 2016;56:1151–64. https://doi.org/10.1002/jcph.689.Suche in Google Scholar PubMed PubMed Central

Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jcim-2020-0129).

Received: 2020-05-09
Accepted: 2020-07-29
Published Online: 2020-10-20

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
  4. Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
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  12. Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
  13. Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
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  15. Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
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  19. Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
  20. Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
  21. Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
  22. Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
  23. Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
  24. Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
  25. Dietary glycine improves urine storage symptoms in urology outpatients
  26. Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
  27. Short Communications
  28. Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
  29. Effect of acupuncture on cognitive task performance of college students: a pilot study
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  32. Case Reports
  33. Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
  34. Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
  35. Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
https://doi.org/10.1515/jcim-2020-0129
Schlagwörter für diesen Artikel
clinical trial; homeopathy; hyperuricemia; pragmatic trial; randomized controlled trial; Urtica urens

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
  4. Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
  5. Review Articles
  6. Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
  7. Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
  8. Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
  9. Research Articles
  10. Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
  11. Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
  12. Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
  13. Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
  14. Neurotoxicity of organic solvents with emphasis on the role of iron
  15. Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
  16. A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
  17. Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
  18. The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
  19. Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
  20. Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
  21. Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
  22. Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
  23. Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
  24. Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
  25. Dietary glycine improves urine storage symptoms in urology outpatients
  26. Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
  27. Short Communications
  28. Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
  29. Effect of acupuncture on cognitive task performance of college students: a pilot study
  30. Yoga for children in the new normal – experience sharing
  31. Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
  32. Case Reports
  33. Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
  34. Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
  35. Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
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