Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
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Noman Anwar
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N. Zaheer Ahmed
Abstract
Emergence of antimicrobial resistance, with practically all newly developed and even more potent antibiotics like carbapenem and colistin, has become a matter of great public health concern. A number of common diseases of public health importance are becoming harder and sometimes impossible to treat due to increased resistance of pathogens. These alarming threats seek prime attention of scientific community to develop newer antibiotics with long-lasting efficacy, least side effects, and low economic burden. Unani classical texts have enormous citations on different infectious diseases. Many single drugs and compound formulations are in vogue since ages for the treatment of infectious diseases. Use of Afaviya (spices), Mufarrehat (exhilarants), Tiryaqi Advia (drugs with antidote properties) and Sirka (vinegar) is highly advocated in treating various infectious diseases. Though, enormous research activities have been undertaken worldwide to explore and develop newer antibiotics from natural resources, indicating massive magnitude of natural products in treating various infectious diseases, however, the higher plants, still largely seems to be unexplored. Moreover, elaborated and well controlled clinical studies are still lacking to authenticate their clinical significance. Hence, a rigorous, well-designed & well-structured research is highly paramount to ascertain the provision of newer, relatively safe and cost effective natural antibiotics.
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Research funding: None declared.
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Author contributions: All the authors have accepted the responsibility for the entire content of the submitted manuscript and approved submission.
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Competing interests: Authors state no conflict of interest.
References
1. Anonymous. National treatment guidelines for antimicrobial use in infectious diseases, version 1.0. National Centre for Disease Control, Directorate General of Health Services Ministry of Health & Family Welfare Government of India; 2016. Available from: http://pbhealth.gov.in/AMR_guideline7001495889.pdf.Suche in Google Scholar
2. Veeraraghawan, B, Walia, K. Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India. Indian J Med Res 2019;149:87–96.10.4103/ijmr.IJMR_214_18Suche in Google Scholar
3. Walia, K, Madhumathi, J, Veeraraghavan, B, Chakrabarti, A, Kapil, A, Ray, P, et al.. Establishing antimicrobial resistance surveillance & research network in India: journey so far. Indian J Med Res 2019;149:164–79. https://doi.org/10.4103/ijmr.ijmr_226_18.Suche in Google Scholar
4. WHO. Antibiotic resistance. World Health Organization; 2018. Available from: https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance.Suche in Google Scholar
5. Mahmood, ZA, Mahmood, SZ. Antibiotic natural products: opportunities and challenges. In: Méndez-Vilas, A, editor. Microbial pathogens and strategies for combating them: science, technology and education. Formatex; 2013:823–33 pp.Suche in Google Scholar
6. Vadhana, P, Singh, BR, Bharadwaj, M, Singh, SV. Emergence of herbal antimicrobial drug resistance in clinical bacterial isolates. Pharm Anal Acta 2015;6. https://doi.org/10.4172/2153-2435.1000434.Suche in Google Scholar
7. Brachman, PS. Infectious diseases—past, present, and future. Int J Epidemiol 2003;32:684–6. https://doi.org/10.1093/ije/dyg282.Suche in Google Scholar
8. Kabiruddin, M. Sharah-e-Asbab. New Delhi: Ejaz Publishing House; 2007, vol. 3 & 4:499–505 pp.Suche in Google Scholar
9. Ibn-e-Rushd, A. Kitab-ul-Kulliyat (Urdu Translation). New Delhi: CCRUM; 1980:77–85, 163, 224, 297, 321–325, 360–370 pp.Suche in Google Scholar
10. Ibn-e-Sina. The canon of medicine (English Trans). New Delhi: Idara Kitab-us-Shafa; 2007, vol. I:172–4 pp.Suche in Google Scholar
11. Baghdadi, IH. Kitab-ul-Mukhtarat Fit Tibb. New Delhi: CCRUM; 2005, vol I:109, 176–80 pp.Suche in Google Scholar
12. Kabiruddin, M. Hummiyat-e-Qanoon. New Delhi: Ejaz Publishing House; 2007:56–112 pp.Suche in Google Scholar
13. Baghdadi, IH. Kitab-ul-Mukhtarat Fit Tibb. New Delhi: CCRUM; 2007, vol IV:238–62 pp.Suche in Google Scholar
14. Razi, AM. Kitab-ul-Mansuri (Urdu Trans). New Delhi: CCRUM; 1991:397–435 pp.Suche in Google Scholar
15. Parvez, A, Ahmed, Z, Anwar, N, Ahmed, K. Razi’s unique approach to Amraz-e-Wabaiya (infectious diseases): an overview. Int J Herb Med 2016;4:176–8.Suche in Google Scholar
16. Anwar, N, Yt, K, Ahmad, MA, Salam, S, Asif, M, Akhtar, M, et al.. Antimicrobial and wound healing potential of Marham-e-Aatshak (A herb-o-mineral formulation). Pak J Pharm Sci 2017;30:1535–43.Suche in Google Scholar
17. Ahmad, T, Mateen, A, Waheed, MA, Abdul Rasheed, NA, Ahmad, SG, Alam, MI, et al.. Antimicrobial activity of some herbal drugs used in Unani system of medicine. Int J Herb Med 2015;2:27–30.Suche in Google Scholar
18. Zhang, J, Gong, J, Ding, Y, Lu, B, Wu, X, Zhang, Y. Antibacterial activity of water-phase extracts from bamboo shavings against food spoilage microorganisms. Afr J Biotechnol 2010;9:7710–7.Suche in Google Scholar
19. Sandhiya, AS, Subhashree, N, Shiva Priya, A, Kumar, S, Aagarwal, A, Dubey, GP. In vitro antioxidant and anti microbial potential of Bambusa arundinacea (Retz.) Willd. Int J Pharm Pharm Sci 2013;5:359–62.Suche in Google Scholar
20. Kumar, MG, Jeyraaj, IA, Jeyaraaj, R, Loganathan, P. Antimicrobial activity of aqueous extract of leaf and stem extract of Santalum album. Ancient Sci Life 2006;25:6–9.Suche in Google Scholar
21. Ashok, K, Jayaprakash, P. Screening of active phytocompounds by GC–MS study and antimicrobial activity in the stem of Santalum album. Int J Curr Pharm Res 2012;4:43–4.Suche in Google Scholar
22. Anagha, K, Manasi, D, Priya, L, Meera, M. Antimicrobial activity of Yashtimadhu (Glycyrrhiza glabra L.) – a review. Int J Curr Microbiol Appl Sci 2014;3:329–36.Suche in Google Scholar
23. Azmi, AA, Jamali, S, Murad, R, Zaidi, AH. Antibacterial activity of joshanda: a polyherbal therapeutic agent used in common cold. Pak J Pharm 2010;27:25–8.Suche in Google Scholar
24. Gupta, VK, Fatima, A, Faridi, U, Negi, AS, Shanker, K, Kumar, JK, et al.. Antimicrobial potential of Glycyrrhiza glabra roots. J Ethnopharmacol 2008;116:377–80. https://doi.org/10.1016/j.jep.2007.11.037.Suche in Google Scholar
25. Mazumder, PM, Pattnayak, S, Parvani, H, Sasmal, D, Rathinavelusamy, P. Evaluation of immunomodulatory activity of Glycyrrhiza glabra L. roots in combination with zinc. Asian Pac J Trop Biomed 2012;2:S15–20. https://doi.org/10.1016/s2221-1691(12)60425-0.Suche in Google Scholar
26. Akinjogunla, OJ, Yah, CS, Eghafona, NO, Ogbemudia, FO. Antibacterial activity of leave extracts of Nymphaea lotus (Nymphaeaceae) on Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin resistant Staphylococcus aureus (VRSA) isolated from clinical samples. Elec J Env Agricult Food Chem 2010;9:1064–73.Suche in Google Scholar
27. Madhav, L, Vinnakoti, A. Antibacterial properties of Nymphaea lotus (Nymphaeaceae) tuber extract against clinical and phyto pathogens. J Pharm Res 2011;4:1231.Suche in Google Scholar
28. Akinjogunla, OJ, Adegoke, AA, Udokang, IP, Adebayo-Tayo, BC. Antimicrobial potential of Nymphaea lotus (Nymphaeaceae) against wound pathogens. J Med Plants Res 2009;3:138–41.Suche in Google Scholar
29. Mir, MA, Rajesh, TS, Rameashkannan, MV, Pala, RA, Balaji, MR. Comparative study of phytochemical analysis and antimicrobial properties of stigmas and stamens of saffron (Crocus sativus L.) found in Kashmir. Adv Biotech 2011;11:35–8.Suche in Google Scholar
30. Kurhade, BB, Vite, MH, Nangude, SL. Antibacterial activity of Rosa damascena miller. Int J Pharm Biomed Res 2011;2:1015–20.Suche in Google Scholar
31. Ozkan, OG, Sagdic, NG, Baydar, H. Antioxidant and antibacterial activities of Rosa damascena flower extracts. Food Sci Technol Int 2004;10:277–81. https://doi.org/10.1177/1082013204045882.Suche in Google Scholar
32. Nascimento, GG, Locatelli, J, Freitas, PC, Silva, GL. Antibacterial activity of plant extracts and phytochemicals on antibiotic-resistant bacteria. Braz J Microbiol 2000;31. https://doi.org/10.1590/S1517-83822000000400003.Suche in Google Scholar
33. Keskin, D, Toroglu, S. Studies on antimicrobial activities of solvent extracts of different spices. J Environ Biol 2011;32:251–6.Suche in Google Scholar
34. Mandal, S, DebMandal, M, Saha, K, Pal, NK. In vitro antibacterial activity of three Indian spices against methicillin-resistant Staphylococcus aureus. Oman Med J 2011;26:319–23. https://doi.org/10.5001/omj.2011.80.Suche in Google Scholar PubMed PubMed Central
35. Pooja, D, Gupta, Tannaz, J, Birdi. Development of botanicals to combat antibiotic resistance. J Ayurveda Integr Med 2017;8:266–75. https://doi.org/10.1016/j.jaim.2017.05.004.Suche in Google Scholar PubMed PubMed Central
36. Savoia, D. Plant-derived antimicrobial compounds: alternative to antibiotics. Future Microbiol 2012;7:979–90. https://doi.org/10.2217/fmb.12.68.Suche in Google Scholar PubMed
37. Miller, LH, Artemisinin, SX. Discovery from the Chinese herbal Garden. Cell 2011;146:855–8. https://doi.org/10.1016/j.cell.2011.08.024.Suche in Google Scholar PubMed PubMed Central
38. Fairhurst, RM, Nayyar, GML, Breman, JG, Hallett, R, Vennerstrom, JL, Duong, S, et al.. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. Am J Trop Med Hyg 2012;87:231–41. https://doi.org/10.4269/ajtmh.2012.12-0025.Suche in Google Scholar PubMed PubMed Central
39. Rasoanaivo, P, Wright, CW, Willcox, ML, Gilbert, B. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. Malar J 2011;10(Suppl 1):S4-S4. https://doi.org/10.1186/1475-2875-10-s1-s4.Suche in Google Scholar PubMed PubMed Central
40. Wright, CW, Linley, PA, Brun, R, Wittlin, S, Hsu, E. Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. Molecules 2010;15:804. https://doi.org/10.3390/molecules15020804.Suche in Google Scholar PubMed PubMed Central
41. Elfawal, MA, Towler, MJ, Reich, NG, Weathers, PJ, Rich, SM. Dried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin. Proc Natl Acad Sci USA 2015;112:821–6. https://doi.org/10.1073/pnas.1413127112.Suche in Google Scholar PubMed PubMed Central
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
- Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
- Review Articles
- Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
- Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
- Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
- Research Articles
- Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
- Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
- Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
- Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
- Neurotoxicity of organic solvents with emphasis on the role of iron
- Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
- A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
- Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
- The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
- Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
- Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
- Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
- Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
- Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
- Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
- Dietary glycine improves urine storage symptoms in urology outpatients
- Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
- Short Communications
- Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
- Effect of acupuncture on cognitive task performance of college students: a pilot study
- Yoga for children in the new normal – experience sharing
- Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
- Case Reports
- Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
- Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
- Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
Artikel in diesem Heft
- Frontmatter
- Reviews
- ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
- Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
- Review Articles
- Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
- Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
- Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
- Research Articles
- Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
- Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
- Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
- Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
- Neurotoxicity of organic solvents with emphasis on the role of iron
- Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
- A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
- Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
- The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
- Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
- Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
- Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
- Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
- Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
- Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
- Dietary glycine improves urine storage symptoms in urology outpatients
- Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
- Short Communications
- Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
- Effect of acupuncture on cognitive task performance of college students: a pilot study
- Yoga for children in the new normal – experience sharing
- Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
- Case Reports
- Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
- Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
- Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
