Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
-
Ayman R. Biuomy
Abstract
Objective
The aim of this study was to investigate the effect of coenzyme Q10 (CoQ10) supplementation on oxidative stress engendered from hypoxia in population live at high altitude.
Methods
This is an intervention study in which 50 females of volunteers population-36 of them who live at high altitude compared with the placebo group (14 from the total population that live at sea level). Blood samples were collected in -anticoagulant tubes from control and high altitude before and after CoQ10 supplementation (150 mg/day for 2, 4 and 8 weeks). Plasma was separated and used for the determination of malondialdehyde (MDA), nitric oxide (NOx), total antioxidant capacity (TAC), paraoxonase (PON1) by spectrophotometer, CoQ10 and vitamin E by high performance liquid chromatography (HPLC).
Results
Our results appeared that TAC, PON1, vitamin E and CoQ10 concentrations were significantly decreased in population at high altitude at base line compared to placebo group population at sea level. Whereas, administration of CoQ10 attenuated all measured parameters especially after eight weeks of administration.
Conclusion
We concluded that coenzyme Q10 supplement at a dose of 150 mg/day has a powerful effect in oxidative stress parameters and increased antioxidant parameters included vitamin E in population with hypoxia after 4 and 8 weeks. So that supplementation positively affects oxidative stress and is recommended CoQ10 supplementation in population who live at high altitude.
Funding source: n/a
-
Research funding: No funding organizations played a role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
-
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
-
Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
References
1. Young, I, Woodside, JV. Antioxidants in health and disease. J Clin Pathol 2001;54:176–86. https://doi.org/10.1136/jcp.54.3.176.Search in Google Scholar
2. Mohanraj, P, Merola, AJ, Wright, VP, Clanton, TL. Antioxidants protect rat diaphragmatic muscle function under hypoxic conditions. J Appl Physiol 1998;84:1960–6. https://doi.org/10.1152/jappl.1998.84.6.1960.Search in Google Scholar
3. Dosek, A, Ohno, H, Acs, Z, Taylor, AW, Radak, Z. High altitude and oxidative stress. Respir Physiol Neurobiol 2007;158:128–31. https://doi.org/10.1016/j.resp.2007.03.013.Search in Google Scholar
4. Khan, S, O’Brien, PJ. Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state. J Biochim Biophys Acta -Mol Cell Res 1995;1269:153–61. https://doi.org/10.1016/0167-4889(95)00112-6.Search in Google Scholar
5. Debevec, T, Pialoux, V, Mekjavic, IB, Eiken, O, Mury, P, Millet, GP. Moderate exercise blunts oxidative stress induced by normobaric hypoxic confinement. Med Sci Sports Exerc 2014;46:33–41. https://doi.org/10.1249/mss.0b013e31829f87ef.Search in Google Scholar
6. Debevec, T, Pialoux, V, Saugy, J, Schmitt, L, Cejuela, R, Mury, P, et al.. Prooxidant/Antioxidant balance in hypoxia: a cross-over study on normobaric vs. hypobaric “Live High-Train Low”. PLoS One; 2015, 10:e0137957. PMID: 26368280; PMCID: PMC4569469. https://doi.org/10.1371/journal.pone.0137957.Search in Google Scholar
7. Willcox, JK, Ash, SL, Catignani, GL. Antioxidants and prevention of chronic disease. Crit Rev Food Sci Nutr 2004;44:275–95. https://doi.org/10.1080/10408690490468489.Search in Google Scholar
8. Frei, J. Reactive oxygen species and antioxidant vitamins: mechanisms of action. Am J Med 1994;97:5S–13S. discussion 22S-28S. https://doi.org/10.1016/0002-9343(94)90292-5.Search in Google Scholar
9. Halliwell, B. Biochemistry of oxidative stress. Biochem Soc Trans 2007;35:1147–50. https://doi.org/10.1042/bst0351147.Search in Google Scholar
10. de Frutos, F, Gea, A, Hernandez-Estefania, R, Rabago, G. Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis. Interact Cardiovasc Thorac Surg 2015;20:254–9. https://doi.org/10.1093/icvts/ivu334.Search in Google Scholar
11. Bhagavan, HN, Chopra, RK. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res 2006;40:445–53. https://doi.org/10.1080/10715760600617843.Search in Google Scholar
12. Doimo, M, Desbats, MA, Cerqua, C, Cassina, M, Trevisson, E, Salviati, L. Genetics of coenzyme q10 deficiency. Mol Syndromol 2014;5:156–62. https://doi.org/10.1159/000362826.Search in Google Scholar
13. Genova, ML, Lenaz, G. New developments on the functions of coenzyme Q in mitochondria. Biofactors 2011;37:330–54. https://doi.org/10.1002/biof.168.Search in Google Scholar
14. Turunen, M, Olsson, J, Dallner, G. Metabolism and function of coenzyme Q. Biochim Biophys Acta 2004;1660:171–99. https://doi.org/10.1016/j.bbamem.2003.11.012.Search in Google Scholar
15. Groneberg, DA, Kindermann, B, Althammer, M, Klapper, M, Vormann, J, Littarru, GP, et al.. Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells. Int J Biochem Cell Biol 2005;37:1208–18. https://doi.org/10.1016/j.biocel.2004.11.017.Search in Google Scholar
16. Laredj, LN, Licitra, F, Puccio, HM. The molecular genetics of coenzyme Q biosynthesis in health and disease. Biochimie 2014;100:78–87. https://doi.org/10.1016/j.biochi.2013.12.006.Search in Google Scholar
17. Bentinger, M, Brismar, K, Dallner, G. The antioxidant role of coenzyme Q. Mitochondrion 2007;7:S41–50. https://doi.org/10.1016/j.mito.2007.02.006.Search in Google Scholar
18. Saini, R. Coenzyme Q10: the essential nutrient. J Pharm Bioallied Sci 2011;3:466–7. https://doi.org/10.4103/0975-7406.84471.Search in Google Scholar
19. Miranda, S, Foncea, R, Guerrero, J, Leighton, F. Oxidative stress and upregulation of mitochondrial biogenesis genes in mitochondrial DNA-depleted HeLa cells. Biochem Biophys Res Commun 1999;258:44–9. https://doi.org/10.1006/bbrc.1999.0580.Search in Google Scholar
20. Gorman, GS, Chinnery, PF, DiMauro, S, Hirano, M, Koga, Y, McFarland, R, et al.. Mitochondrial diseases. Nat Rev Dis Prim 2016;2:16080. https://doi.org/10.1038/nrdp.2016.80.Search in Google Scholar
21. Yubero, D, Montero, R, Martín, MA, Montoya, J, Ribes, A, Grazina, M, et al.. Secondary coenzyme Q10 deficiencies in oxidative phosphorylation (OXPHOS) and non-OXPHOS disorders. Mitochondrion 2016;30:51–8. https://doi.org/10.1016/j.mito.2016.06.007.Search in Google Scholar
22. Pravst, I, Zmitek, K, Zmitek, J. Coenzyme Q10 contents in foods and fortification strategies. Crit Rev Food Sci Nutr 2010;50:269–80. https://doi.org/10.1080/10408390902773037.Search in Google Scholar
23. Buhmann, C, Arlt, S, Kontush, A, Möller-Bertram, T, Sperber, S, Oechsner, M, et al.. Plasma and CSF markers of oxidative stress are increased in Parkinson’s disease and influenced by antiparkinsonian medication. Neurobiol Dis 2004;15:160–70. https://doi.org/10.1016/j.nbd.2003.10.003.Search in Google Scholar
24. Mischley, LK, Allen, J, Bradley, R. Coenzyme Q10 deficiency in patients with Parkinson’s disease. J Neurol Sci 2012;318:72–5. https://doi.org/10.1016/j.jns.2012.03.023.Search in Google Scholar
25. González-Guardia, L, Yubero-Serrano, EM, Delgado-Lista, J, Perez-Martinez, P, Garcia-Rios, A, Marin, C, et al.. Effects of the mediterranean diet supplemented with coenzyme q10 on metabolomic profiles in elderly men and women. J Gerontol A Biol Sci Med Sci 2014;70:78–84. https://doi.org/10.1093/gerona/glu098.Search in Google Scholar
26. Kwong, LK, Kamzalov, S, Rebrin, I, Bayne, AC, Jana, CK, Morris, P, et al.. Effects of coenzyme Q 10 administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med 2002;33:627–38. https://doi.org/10.1016/s0891-5849(02)00916-4.Search in Google Scholar
27. Botsoglou, NA, Fletouris, DJ, Papageorgiou, GE, Vassilopoulos, VN, Mantis, AJ, Trakatellis, AG. Rapid, sensitive, and specific thiobarbituric acid method for measuring lipid peroxidation in animal tissue, food, and feedstuff samples. J Agric Food Chem 1994;42:1931–7. https://doi.org/10.1021/jf00045a019.Search in Google Scholar
28. Chung, YC, Chen, SJ, Peng, HY, Chou, S. Antihypertensive and antioxidant effects of the Graptopetalum paraguayense E. Walther extract in spontaneously hypertensive rats. Bot Stud 2009;89:2678–86. https://doi.org/10.1002/jsfa.3774.Search in Google Scholar
29. Leelarungrayub, D, Sawattikanon, N, Klaphajone, J, Pothongsunan, P, Bloomer, RJ. Coenzyme Q10 supplementation decreases oxidative stress and improves physical performance in young swimmers: a pilot study. Open Sports Med J 2010;4:1–8. https://doi.org/10.2174/1874387001004010001.Search in Google Scholar
30. Re, R, Pellegrini, N, Proteggente, A, Pannala, A, Yang, M, Rice-Evans, C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 1999;26:1231–7. https://doi.org/10.1016/s0891-5849(98)00315-3.Search in Google Scholar
31. Hussein, J, Abdel Latif, Y, Medhat, D, Refaat, E, El Nahrery, I, Farrag, AR. Pomegranate juice attenuates elevation of asymmetric dimethylarginine in indomethacin induced peptic ulcer. World J Pharmaceut Res 2014;3:110–21.Search in Google Scholar
32. Hussein, J, Abo-elmatty, D, El-Khayat, Z, Abdel Latif, Y. Brain neurotransmitters in diabetic rats treated with coenzyme Q10. Int J Pharm Pharmaceut Sci 2012;4:554–6.Search in Google Scholar
33. Zaki, ME, El-Bassyouni, HT, Tosson, A, Youness, E, Hussein, J. Coenzyme Q10 and pro-inflammatory markers in children with down syndrome: clinical and biochemical aspects. J Pediatr 2017;93:100–4. https://doi.org/10.1016/j.jpedp.2016.04.007.Search in Google Scholar
34. Abdel Ghany, EAG, Alsharany, W, Ali, AA, Youness, ER, Hussein, JS. Anti-oxidant profiles and markers of oxidative stress in preterm neonates. Paediatr Int Child Health 2016;36:134–40. https://doi.org/10.1179/2046905515y.0000000017.Search in Google Scholar
35. Imai, H, Kashiwazaki, H, Suzuki, T, Kaeuto, M, Himeno, S, Watanabe, C, et al.. Selenium levels and glutathione6peroxidase activities in blood in an andean high-altitude population. J Nutr Sci Vitaminol 1995;41:349–61. https://doi.org/10.3177/jnsv.41.349.Search in Google Scholar
36. Chao, W-H, Askew, EW, Roberts, DE, Wood, SM, Perkins, JB. Oxidative stress in humans during work at moderate altitude. J Nutr 1999;129:2009–12. https://doi.org/10.1093/jn/129.11.2009.Search in Google Scholar
37. Niklowitz, P, Sonnenschein, A, Janetzky, B, Andler, W, Menke, T. Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. Int J Biol Sci 2007;3:257. https://doi.org/10.7150/ijbs.3.257.Search in Google Scholar
38. Neergheen, V, Chalasani, A, Wainwright, L, Yubero, D, Montero, R, Artuch, R, et al.. Coenzyme Q10 in the treatment of mitochondrial disease. J Inborn Errors Metab Screen 2017;5. https://doi.org/10.1177/2326409817707771.Search in Google Scholar
39. Magalhães, J, Ferreira, R, Neuparth, MJ, Oliveira, PJ, Marques, F, Ascensão, A. Vitamin E prevents hypobaric hypoxia-induced mitochondrial dysfunction in skeletal muscle. Clin Sci 2007;113:459–66. https://doi.org/10.1042/cs20070075.Search in Google Scholar
© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Reviews
- ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
- Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
- Review Articles
- Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
- Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
- Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
- Research Articles
- Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
- Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
- Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
- Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
- Neurotoxicity of organic solvents with emphasis on the role of iron
- Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
- A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
- Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
- The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
- Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
- Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
- Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
- Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
- Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
- Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
- Dietary glycine improves urine storage symptoms in urology outpatients
- Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
- Short Communications
- Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
- Effect of acupuncture on cognitive task performance of college students: a pilot study
- Yoga for children in the new normal – experience sharing
- Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
- Case Reports
- Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
- Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
- Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
Articles in the same Issue
- Frontmatter
- Reviews
- ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
- Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
- Review Articles
- Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
- Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
- Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
- Research Articles
- Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
- Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
- Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
- Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
- Neurotoxicity of organic solvents with emphasis on the role of iron
- Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
- A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
- Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
- The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
- Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
- Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
- Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
- Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
- Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
- Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
- Dietary glycine improves urine storage symptoms in urology outpatients
- Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
- Short Communications
- Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
- Effect of acupuncture on cognitive task performance of college students: a pilot study
- Yoga for children in the new normal – experience sharing
- Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
- Case Reports
- Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
- Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
- Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
