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Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition

  • Edwige Nana Tchoupang , Sylvin Benjamin Ateba , Marie Alfrede Mvondo , Derek Tantoh Ndinteh , Télesphore Benoit Nguelefack , Stéphane Zingue , Liselotte Krenn and Dieudonné Njamen EMAIL logo
Published/Copyright: April 5, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 18 Issue 3

Abstract

Objectives

There is a growing body of evidence indicating the potential of culinary herbs and spices to decrease the incidence of several chronic diseases or conditions. Because of this, the WHO recommends their regular consumption. In the Cameroonian culinary practices, “Nkui” is a famous dish made from a mixture of 10 spices. In our previous study, the ethanolic extract of this mixture exhibited promising estrogenic properties. Thus, this study aimed to evaluate its protective effects on some menopause-related cardiovascular and bone disorders.

Methods

For this purpose, a post-menopause-like model (ovariectomized rats) has been used. Animals were orally treated with the “Nkui” extract for 60 days. The investigation focused on the oxidative stress status, endothelial function (NO bioavailability), lipid profile, and bone mass, biochemical (calcium and inorganic phosphorus contents, serum alkaline phosphatase activity) and histomorphological features.

Results

The extract regulated lipid metabolism in a way to prevent accumulation of abdominal fat, gain in body weight and increased atherogenic indexes induced by ovariectomy. It prevented menopause-related low levels of nitric oxide and oxidative stress damage by increasing superoxide dismutase and catalase activities, while reducing glutathione and malondialdehyde levels in the heart and aorta. Moreover, it prevented ovariectomy-induced bone mass loss, bone marrow disparities and the disorganization of the trabecular network. It also increased femur calcium and inorganic phosphorus contents.

Conclusions

These results suggest that a regular consumption of “Nkui” may have health benefits on cardiovascular system and osteoporosis, major health issues associated with menopause.

Keywords: cardiovascular disorders; functional food; osteoporosis; oxidative stress damage; phytoestrogens; post-menopause-like model
Corresponding author: Dieudonné Njamen, Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg, South Africa; and Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde, Cameroon. Phone: +237 679 424 710, E-mail:

Acknowledgments

The authors are grateful for the support of the Alexander von Humboldt Foundation and appreciate the assistance provided by Prof. Pierre Watcho and Mr. Christian Fofie (Department of Animal Biology, University of Dschang, Cameroon) during assessment of antioxidant activity.

  1. Research funding: None declared.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: No funding organizations played a role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Ethical statement: The experiment was conducted following the procedures recommended by the 12 European Union on the protection of animals used for scientific purposes (CEE Council 1386/609; Reg. number FWA-IRD 0001954), adopted by the Cameroon Institutional National 14 Ethics Committee.

  5. Availability of data and materials: The data and materials used in this study are available upon request from the authors. Please contact Prof. Dr. Stephane Zingue ().

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Received: 2020-07-21
Accepted: 2020-10-12
Published Online: 2021-04-05

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
  4. Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
  5. Review Articles
  6. Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
  7. Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
  8. Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
  9. Research Articles
  10. Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
  11. Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
  12. Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
  13. Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
  14. Neurotoxicity of organic solvents with emphasis on the role of iron
  15. Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
  16. A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
  17. Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
  18. The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
  19. Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
  20. Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
  21. Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
  22. Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
  23. Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
  24. Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
  25. Dietary glycine improves urine storage symptoms in urology outpatients
  26. Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
  27. Short Communications
  28. Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
  29. Effect of acupuncture on cognitive task performance of college students: a pilot study
  30. Yoga for children in the new normal – experience sharing
  31. Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
  32. Case Reports
  33. Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
  34. Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
  35. Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
https://doi.org/10.1515/jcim-2020-0127
Keywords for this article
cardiovascular disorders; functional food; osteoporosis; oxidative stress damage; phytoestrogens; post-menopause-like model

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
  4. Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
  5. Review Articles
  6. Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
  7. Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
  8. Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
  9. Research Articles
  10. Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
  11. Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
  12. Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
  13. Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
  14. Neurotoxicity of organic solvents with emphasis on the role of iron
  15. Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
  16. A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
  17. Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
  18. The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
  19. Effectiveness of wet cupping therapy on relieving pain in patients with chronic migraine: an observational study
  20. Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
  21. Effect of Sudarshan Kriya Yoga (SKY) on daytime and situational sleep propensity in novice practitioners: a prospective cohort study
  22. Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
  23. Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
  24. Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
  25. Dietary glycine improves urine storage symptoms in urology outpatients
  26. Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
  27. Short Communications
  28. Terminalia arjuna induced testicular assault through Leydig cell derangement: an in vitro approach
  29. Effect of acupuncture on cognitive task performance of college students: a pilot study
  30. Yoga for children in the new normal – experience sharing
  31. Effect of Arogya Raksha Panchatantra (five lifestyle principles) on hematological parameters and anthropometric measures among healthy volunteers: a pilot study
  32. Case Reports
  33. Yellow phosphorous ingestion cause liver dysfunction and internal bleeding: a case study
  34. Effect of yoga on plasma glucose, lipid profile, blood pressure and insulin requirement in a patient with type 1 diabetes mellitus
  35. Management of Vipadika with Mahisha Gritha Padanimajjana – a case report
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