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Neurotoxicity of organic solvents with emphasis on the role of iron

  • Eman M. Shahy ORCID logo , Khadiga S. Ibrahim , Heba Mahdy-Abdallah , Mona M. Taha , Amal Saad-Hussien and Salwa F. Hafez
Published/Copyright: February 1, 2021
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 18 Issue 3

Abstract

Background

Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones.

Objectives

This study investigated the role of iron in association with some neurotransmitters for diagnosis of neurotoxicity of OS.

Methods

The study included 90 workers, 50 occupationally exposed to OS and 40 representing control group. Blood samples were collected from the included subjects for determination of serum iron, total iron binding capacity (TIBC), serotonin and gamma-aminobutyric acid (GABA).

Results

Revealed reduction in serotonin level and serum iron. However, the elevation in GABA and TIBC was observed. The duration of exposure was significantly correlated with iron and serotonin while it was positively correlated with GABA and TIBC.

Conclusions

Elevated GABA and TIBC with decreased serotonin and serum iron can be used as early diagnostic measures to detect the neurotoxic effects of OS.

Keywords: GABA; neurotoxicity; occupational exposure; organic solvents; serotonin; serum iron
Corresponding author: Eman M. Shahy, Assistant Professor, Environmental Biochemistry and Molecular Biology, Environmental & Occupational Medicine Department, National Research Centre, El-Buhouth St. Dokki, Cairo, 12622, Egypt, Fax: +00202 33370931, E-mail:

  1. Research funding: The author(s) received financial support for the research from National Research Centre.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical statement: Approval of the ethics committee at the National Research Centre was taken prior to the study (registration number 15178). Written Consent was obtained from each participant in the current study.

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Received: 2019-04-14
Accepted: 2020-07-19
Published Online: 2021-02-01

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2019-0103
Keywords for this article
GABA; neurotoxicity; occupational exposure; organic solvents; serotonin; serum iron

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. ‘Ilāj bi’l-Tadbīr (regimenal therapy): a core mode of Unani treatment
  4. Understanding hormones in terms of humours (Akhlat) in Unani system of medicine
  5. Review Articles
  6. Understanding Humma-e-Wabai (epidemic fever) and Amraz-e-Wabai (epidemic disease) in the light of Unani medicine
  7. Emergence of antimicrobial resistance and magnitude of Unani medicine – scope and challenges
  8. Medicinal importance of Papra (Podophyllum hexandrum Royle) in Unani System of Medicine
  9. Research Articles
  10. Comparative effects of berberine and piperine on the neuroprotective potential of neostigmine
  11. Neera, a non-fermented traditional drink from coconut spadix restores the redox status in sodium fluoride intoxicated mice
  12. Evaluation of wound healing potential of Bhallatakadi Ghrita – cow ghee based polyherbal formulation: in-vivo excision and incision wound model
  13. Effects of co-administration of Unani pharmacopoeia formulations Qurs Tabasheer Sartani and Arq Hara Bhara with CAT-I antitubercular drugs in rats
  14. Neurotoxicity of organic solvents with emphasis on the role of iron
  15. Regular consumption of “Nkui”, a Cameroonian traditional dish, may protect against cardiovascular and bone disorders in an estrogen deficiency condition
  16. A spatial-temporal study of complementary and alternative medicine (CAM) by type: exploring localization economies implications in urban areas in Ontario
  17. Complementary and alternative interventions for stroke recovery – a narrative overview of the published evidence
  18. The feasibility and acceptability of hypnotherapy among overweight and obese individuals in a Malaysia’s public university
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  20. Effect of aromatherapy massage by orange essential oil on post-cesarean anxiety: a randomized clinical trial
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  22. Comparison of instability resistance training, traditional resistance training and plyometric training on athletic performance parameters
  23. Individualized homeopathic medicines and Urtica urens mother tincture in treatment of hyperuricemia: an open, randomized, pragmatic, pilot trial
  24. Association of microsomal epoxide hydrolase gene (fast genotype) with lung functions impairment in wood workers
  25. Dietary glycine improves urine storage symptoms in urology outpatients
  26. Hypoxia-induced oxidative stress in high altitude population: impact of coenzyme Q10 supplementation
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