Optimisation and validation of liquid chromatographic and partial least-squares-1 methods for simultaneous determination of enalapril maleate and nitrendipine in pharmaceutical preparations
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Mehmet Caglayan
,
Ismail Palabiyik
Abstract
Simultaneous determination of enalapril maleate (ENA) and nitrendipine (NIT) in pharmaceutical preparations was performed using liquid chromatography (LC) and the partial least-squares-1 (PLS-1) method. In LC, the separation was achieved on a C8 column and the optimum mobile phase for good separation in a gradient elution programme was found to be acetonitrile-water (φ r = 81: 19) and optimum flow-rate, temperature, injection volume, and detection wavelength were set at 1.0 mL min−1, 25°C, 10 μL, and 210 nm, respectively. Dienogest was selected as an internal standard. In the spectrophotometry, a PLS-1 chemometric method was used. The absorbance data matrix related to the concentration data matrix was established by measurement of absorbances in their zero order spectra with an increment of Δλ = 1 nm in the 220–290 nm range for ENA and with Δλ = 1 nm in the 230–290 nm range for NIT in the PLS-1 method. Following this step, calibration was established by using this data matrix to predict the unknown concentrations of ENA and NIT in their binary mixture. These optimised methods were validated and successfully applied to a pharmaceutical preparation in tablet form and the results were subjected to comparison.
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© 2011 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
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- Optimisation and validation of liquid chromatographic and partial least-squares-1 methods for simultaneous determination of enalapril maleate and nitrendipine in pharmaceutical preparations
- Chemiluminescence parameters of peroxynitrous acid in the presence of short-chain alcohols and Ru(bpy)32+
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- Toxicity reduction of 2-(5-nitrofuryl)acrylic acid following Fenton reaction treatment
- Synthesis and characterisation of alkaline earth-iron(III) double hydroxides
- Effect of cyclodextrins on pH-induced conformational transition of poly(methacrylic acid)
- Polyamine-substituted epoxy-grafted silica for aqueous metal recovery
- Helical silica nanotubes: Nanofabrication architecture, transfer of helix and chirality to silica nanotubes
- DFT calculations on the Friedel-Crafts benzylation of 1,4-dimethoxybenzene using ZnCl2 impregnated montmorillonite K10 — inversion of relative selectivities and reactivities of aryl halides
- Facile synthesis of 3-aryl-1-((4-aryl-1,2,3-selenadiazol-5-yl)sulfanyl)isoquinolines
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