Startseite Methylprednisolone release from agar-Carbomer-based hydrogel: a promising tool for local drug delivery
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Methylprednisolone release from agar-Carbomer-based hydrogel: a promising tool for local drug delivery

  • Filippo Rossi EMAIL logo , Tommaso Casalini , Marco Santoro , Andrea Mele und Giuseppe Perale
Veröffentlicht/Copyright: 28. September 2011
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Chemical Papers
Aus der Zeitschrift Chemical Papers Band 65 Heft 6

Abstract

A number of studies and works in drug delivery literature are focused on the understanding and modelling of transport phenomena, the pivotal point of a good scaffold design for tissue engineering. Accurate knowledge of the diffusion coefficient of an active drug plays a key role in the analysis, prediction of their kinetics and formulation of efficient drug delivery systems. In this work, the kinetics of the release of methylprednisolone from agar-Carbomer hydrogel were studied taking into consideration the different drug concentrations and clearances typically achieved in in vitro or in vivo tests. Starting from the experiments it is possible to model the transport phenomenon and to calculate the diffusion coefficient through the hydrogel matrix.

Keywords: biomaterials; diffusion; drug delivery; hydrogel; methylprednisolone

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Published Online: 2011-9-28
Published in Print: 2011-12-1

© 2011 Institute of Chemistry, Slovak Academy of Sciences

Artikel in diesem Heft

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https://doi.org/10.2478/s11696-011-0059-5
Schlagwörter für diesen Artikel
biomaterials; diffusion; drug delivery; hydrogel; methylprednisolone

Artikel in diesem Heft

  1. Determination of four trace preservatives in street food by ionic liquid-based dispersive liquid-liquid micro-extraction
  2. Optimisation and validation of liquid chromatographic and partial least-squares-1 methods for simultaneous determination of enalapril maleate and nitrendipine in pharmaceutical preparations
  3. Chemiluminescence parameters of peroxynitrous acid in the presence of short-chain alcohols and Ru(bpy)32+
  4. Investigation of multi-layered silicate ceramics using laser ablation optical emission spectrometry, laser ablation inductively coupled plasma mass spectrometry, and electron microprobe analysis
  5. Simultaneous analysis of three catecholamines by a kinetic procedure: comparison of prediction performance of several different multivariate calibrations
  6. Enzymatic saccharification of cellulose in aqueous-ionic liquid 1-ethyl-3-methylimidazolium dimethylphosphate-DMSO media
  7. Statistical and evolutionary optimisation of operating conditions for enhanced production of fungal l-asparaginase
  8. Extraction of phytosterols from tall oil soap using selected organic solvents
  9. Dynamic simulations of waste water treatment plant operation
  10. Influence of recycling and temperature on the swelling ability of paper
  11. Zirconium(IV) 4-sulphophenylethyliminobismethylphosphonate as an efficient and reusable catalyst for one-pot synthesis of 3,4-dihydropyrimidones under solvent-free conditions
  12. Toxicity reduction of 2-(5-nitrofuryl)acrylic acid following Fenton reaction treatment
  13. Synthesis and characterisation of alkaline earth-iron(III) double hydroxides
  14. Effect of cyclodextrins on pH-induced conformational transition of poly(methacrylic acid)
  15. Polyamine-substituted epoxy-grafted silica for aqueous metal recovery
  16. Helical silica nanotubes: Nanofabrication architecture, transfer of helix and chirality to silica nanotubes
  17. DFT calculations on the Friedel-Crafts benzylation of 1,4-dimethoxybenzene using ZnCl2 impregnated montmorillonite K10 — inversion of relative selectivities and reactivities of aryl halides
  18. Facile synthesis of 3-aryl-1-((4-aryl-1,2,3-selenadiazol-5-yl)sulfanyl)isoquinolines
  19. Influence of trimethoxy-substituted positions on fluorescence of heteroaryl chalcone derivatives
  20. A simple and efficient one-pot synthesis of Hantzsch 1,4-dihydropyridines using silica sulphuric acid as a heterogeneous and reusable catalyst under solvent-free conditions
  21. Methylprednisolone release from agar-Carbomer-based hydrogel: a promising tool for local drug delivery
  22. 2-Alkylsulphanyl-4-pyridinecarbothioamides — inhibitors of oxygen evolution in freshwater alga Chlorella vulgaris
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