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Application of gas chromatography-mass spectrometry in research of traditional Chinese medicine

  • Jiesheng Ye EMAIL logo
Veröffentlicht/Copyright: 25. August 2009
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Abstract

It is well known that traditional Chinese medicine (TCM) plays a more and more important role in modern pharmaceutical industry. It has been used in the therapy of many diseases for several thousand years because of its high pharmacological activity, low toxicity and rare side effects. In TCM, as an important group of secondary metabolites, essential oils have attracted a great deal of attention in recent years. Gas chromatography-mass spectrometry (GC-MS) is the most commonly used technique for the analysis of liposoluble constituents, especially volatile/semi-volatile compounds, and their metabolites in biological fluids due to its high resolution, selectivity and sensitivity. This review briefly describes the applications of GC-MS for the isolation and characterization of volatile compounds from TCM. In addition, GC-MS methods adopted in the metabolic profiling of volatile compounds in biological matrices are also described.

[1] Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils — A review. Food and Chemical Toxicology, 46, 446–475. DOI: 10.1016/j.fct.2007.09.106. http://dx.doi.org/10.1016/j.fct.2007.09.10610.1016/j.fct.2007.09.106Suche in Google Scholar PubMed

[2] Cao, J., Qi, M. L., Zhang, Y., Zhou, S., Shao, Q. L., & Fu, R. N. (2006). Analysis of volatile compounds in Curcuma wenyujin Y. H. Chen et C. Ling by headspace solvent microextraction-gas chromatography-mass spectrometry. Analytica Chimica Acta, 561, 88–95. DOI: 10.1016/j.aca.2006.01.040. http://dx.doi.org/10.1016/j.aca.2006.01.04010.1016/j.aca.2006.01.040Suche in Google Scholar

[3] Chen, K. J., & Li, C. S. (1998). Xin Bian Kang Shuai Lao Zhong Yao Xue (pp.27–28), Beijing: People’s Medical Publishing House. Suche in Google Scholar

[4] Chen, M., Zhao, L., & Jia, W. (2005). Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model. Journal of Proteome Research, 4, 2391–2396. DOI: 10.1021/pr050158o. http://dx.doi.org/10.1021/pr050158o10.1021/pr050158oSuche in Google Scholar PubMed

[5] Chen, X. H., Liu, Q., Chen, X. X., & Zhang, L. (2008). Analysis and comparison of the volatile oil from different parts of Pogostemon cablin (Blanco) Benth by GC-MS. Journal of Liaoning University of TCM, 10, 127–128. Suche in Google Scholar

[6] Deng, C. H., Yao, N., Wang, A. Q., & Zhang, X. M. (2005). Determination of essential oil in a traditional Chinese medicine, Fructus amomi by pressurized hot water extraction followed by liquid-phase microextraction and gas chromatography-mass spectrometry. Analytica Chimica Acta, 536, 237–244. DOI: 10.1016/j.aca.2004.12.044. http://dx.doi.org/10.1016/j.aca.2004.12.04410.1016/j.aca.2004.12.044Suche in Google Scholar

[7] Deng, C., Mao, Y., Hu, F., Zhang, X. (2007). Development of gas chromatography-mass spectrometry following microwave distillation and simultaneous headspace single-drop microextraction for fast determination of volatile fraction in Chinese herb. Journal of Chromatography A, 1152, 193–198. DOI: 10.1016/j.chroma.2006.08.074. http://dx.doi.org/10.1016/j.chroma.2006.08.07410.1016/j.chroma.2006.08.074Suche in Google Scholar PubMed

[8] Dong, L., Wang, J., Deng, C., & Shen, X. (2007a). Gas chromatography-mass spectrometry following pressurized hot water extraction and solid-phase microextraction for quantification of eucalyptol, camphor, and borneol in Chrysanthemum flowers. Journal of Separation Science, 30, 86–89. DOI: 10.1002/jssc.200600207. http://dx.doi.org/10.1002/jssc.20060020710.1002/jssc.200600207Suche in Google Scholar PubMed

[9] Dong, L., Deng, C., Wang, J., & Shen, X. (2007b). Fast determination of paeonol in plasma by headspace solid-phase microextraction followed by gas chromatography-mass spectrometry. Analytica Chimica Acta, 585, 76–80. DOI: 10.1016/j.aca.2006.12.024. http://dx.doi.org/10.1016/j.aca.2006.12.02410.1016/j.aca.2006.12.024Suche in Google Scholar PubMed

[10] Dong, L., Deng, C., Wang, B., & Shen, X. (2007c). Fast determination of Z-ligustilide in plasma by gas chromatography/mass spectrometry following headspace single-drop microextraction. Journal of Separation Science, 30, 1318–1325. DOI: 10.1002/ jssc.200600379. http://dx.doi.org/10.1002/jssc.20060037910.1002/jssc.200600379Suche in Google Scholar PubMed

[11] Drašar, P., & Moravcova, J. (2004). Recent advances in analysis of Chinese medical plants and traditional medicines. Journal of Chromatography B, 812, 3–21. DOI: 10.1016/j.jchromb.2004.09.037. 10.1016/j.jchromb.2004.09.037Suche in Google Scholar PubMed

[12] Du, S. S., Xu, Y. C., & Wei, L. X. (2003). Analysis of the fatty acids in Tiannanxing (the Rhizome of Arisaema erubescens). Journal of Beijing University of Traditional Chinese Medicine, 26, 44–46. Suche in Google Scholar

[13] Du, Z. Q., Xia, H. L., Jiang, H. X., Zhang, B. F., & Meng, F. (2003). GC-MS analysis of essential oil from Lindera strychnifolia Vill. Chinese Traditional Herbal Drugs, 34, 308–310. Suche in Google Scholar

[14] Fan, X.-H., Cheng, Y.-Y., Ye, Z.-L., Lin, R.-C., & Qian, Z.-Z. (2006). Multiple chromatographic fingerprinting and its application to the quality control of herbal medicines. Analytica Chimica Acta, 555, 217–224. DOI: 10.1016/j.aca.2005.09.037. http://dx.doi.org/10.1016/j.aca.2005.09.03710.1016/j.aca.2005.09.037Suche in Google Scholar

[15] Gherman, C., Culea, M., & Cozar, O. (2000). Comparative analysis of some active principles of herb plants by GC/MS. Talanta, 53, 253–262. DOI: 10.1016/S0039-9140(00)00458-6. http://dx.doi.org/10.1016/S0039-9140(00)00458-610.1016/S0039-9140(00)00458-6Suche in Google Scholar

[16] Gong, F., Liang, Y.-Z., Xie, P.-S., & Chau, F.-T. (2003). Information theory applied to chromatographic fingerprint of herbal medicine for quality control. Journal of Chromatography A, 1002, 25–40. DOI: 10.1016/S0021-9673(03)00648-4. http://dx.doi.org/10.1016/S0021-9673(03)00648-410.1016/S0021-9673(03)00648-4Suche in Google Scholar

[17] Guo, F.-Q., Liang, Y.-Z., Xu, C.-J., & Huang, L.-F. (2003). Determination of the volatile chemical constituents of Notoptergium incium by gas chromatography-mass spectrometry iterative or non-iterative chemometrics resolution methods. Journal of Chromatography A, 1016, 99–110. DOI: 10.1016/S0021-9673(03)01327-X. http://dx.doi.org/10.1016/S0021-9673(03)01327-X10.1016/S0021-9673(03)01327-XSuche in Google Scholar

[18] Guo, F.-Q., Liang, Y.-Z., Xu, C.-J., Huang, L.-F., & Li, X.-N. (2004). Comparison of the volatile constituents of Artemisia capillaris from different locations by gas chromatography-mass spectrometry and projection method. Journal of Chromatography A, 1054, 73–79. DOI: 10.1016/j.chroma.2004.08.122. 10.1016/S0021-9673(04)01473-6Suche in Google Scholar

[19] Hui, R.-H., Hou, D.-Y., Li, T.-C., Liu, X.-Y., & Li, X.-C. (2008). Study on the volatile constituents in leaf of Syringa Oblata Lindl. at different season. Journal of Chinese Mass Spectrometry Society, 29, 18–20. Suche in Google Scholar

[20] Jiang, H., Xie, Z., Koo, H. J., McLaughlin, S. P., Timmermann, B. N., & Gang, D. R. (2006). Metabolic profiling and phylogenetic analysis of medicinal Zingiber species: Tools for authentication of ginger (Zingiber officinale Rosc.). Phytochemistry, 67, 1673–1685. DOI: 10.1016/j.phytochem.2005.08.001. http://dx.doi.org/10.1016/j.phytochem.2005.08.00110.1016/j.phytochem.2005.08.001Suche in Google Scholar

[21] Kelly, L. (2001). Herbal medicines-analytical challenges faced by a regulatory laboratory. In International symposium on quality of traditional Chinese medicine with chromatographic fingerprint, 20–21 February 2001 (p. 57). Guangzhou, China. Suche in Google Scholar

[22] Lao, S. C., Li, S. P., Kan, K. K. W., Li, P., Wan, J. B., Wang, Y. T., Dong, T. T. X., & Tsim, K. W. K. (2004). Identification and quantification of 13 components in Angelica sinensis (Danggui) by gas chromatography-mass spectrometry coupled with pressurized liquid extraction. Analytica Chimica Acta, 526, 131–137. DOI: 10.1016/j.aca.2004. 09.050. http://dx.doi.org/10.1016/j.aca.2004.09.05010.1016/j.aca.2004.09.050Suche in Google Scholar

[23] Li, F., Xiong, Z., Lu, X., Qin, F., & Li, X. (2006). Strategy and chromatographic technology of quality control for traditional Chinese medicines. Chinese Journal of Chromatography, 24, 537–544. DOI: 10.1016/S1872-2059(06)60022-9. http://dx.doi.org/10.1016/S1872-2059(06)60022-910.1016/S1872-2059(06)60022-9Suche in Google Scholar

[24] Li, W.-F., Jiang, J.-G., & Chen, J. (2008a). Chinese medicine and its modernization demands. Archives of Medical Research, 39, 246–251. DOI: 10.1016/j.arcmed.2007.09.011. http://dx.doi.org/10.1016/j.arcmed.2007.09.01110.1016/j.arcmed.2007.09.011Suche in Google Scholar PubMed

[25] Li, Q., Liu, L. Q., Xu, H. D., Liu, L. P., & You, X. Y. (2008b). Study on organic acids components in Chaenomeles sinensis (Thouin) Koehne. Acta Agriculturae Boreali-occidentalis Sinica, 17, 207–210. Suche in Google Scholar

[26] Liang, Q., Liang, Z.-S., Wang, J.-R., & Xu, W.-H. (2009). Essential oil composition of Salvia miltiorrhiza flower. Food Chemistry, 113, 592–594. DOI: 10.1016/j.foodchem.2008.08.035. http://dx.doi.org/10.1016/j.foodchem.2008.08.03510.1016/j.foodchem.2008.08.035Suche in Google Scholar

[27] Liang, Y.-Z., Xie, P., & Chan, K. (2004). Quality control of herbal medicines. Journal of Chromatography B, 812, 53–70. DOI: 10.1016/j.jchromb.2004.08.041. 10.1016/j.jchromb.2004.08.041Suche in Google Scholar PubMed

[28] Lin, C.-T., Chen, C.-J., Lin, T.-Y., Tung, J. C., & Wang, S.-Y. (2008). Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. Bioresource Technology, 99, 8783–8787. DOI: 10.1016/j.biortech.2008.04.041. http://dx.doi.org/10.1016/j.biortech.2008.04.04110.1016/j.biortech.2008.04.041Suche in Google Scholar

[29] Liu, L., Song, G., & Hu, Y. (2007). GC-MS analysis of the essential oils of Piper nigrum L. and Piper longum L. Chromatographia, 66, 785–790. DOI: 10.1365/s10337-007-0408-2. http://dx.doi.org/10.1365/s10337-007-0408-210.1365/s10337-007-0408-2Suche in Google Scholar

[30] Liu, S., Yi, L.-Z., & Liang, Y.-Z. (2008). Traditional Chinese medicine and separation science. Journal of Separation Science, 31, 2113–2137. DOI: 10.1002/jssc. 200800134. http://dx.doi.org/10.1002/jssc.20080013410.1002/jssc.200800134Suche in Google Scholar

[31] Liu, Y. F., Yan, Y. N., & Wu, Y. (2004). GC-MS analysis of chemical components of the volatile oil from the aerial part of Bupleurum Chinense. Journal of Beijing University of Traditional Chinese Medicine, 5, 59–61. Suche in Google Scholar

[32] Lu, H. M., Liang, Y. Z., Yi, L. Z., & Wu, X. J. (2006). Anti-inflammatory effect of Houttuynia cordata injection. Journal of Ethnopharmacology, 104, 245–249. DOI: 10.1016/j.jep. 2005.09.012. http://dx.doi.org/10.1016/j.jep.2005.09.01210.1016/j.jep.2005.09.012Suche in Google Scholar

[33] Lu, X. H., & Chen, H. B. (2004). The challenges and opportunities of traditional Chinese medicine modernization. Journal of Practical Medicine Technology, 11, 2028–2029. Suche in Google Scholar

[34] McCune, L. M., & Johns, T. (2007). Antioxidant activity relates to plant part, life form and growing condition in some diabetes remedies. Journal of Ethnopharmacology, 112, 461–469. DOI: 10.1016/j.jep.2007.04.006. http://dx.doi.org/10.1016/j.jep.2007.04.00610.1016/j.jep.2007.04.006Suche in Google Scholar

[35] Message, G. M. (1984). Practical aspects of gas chromatography/mass spectrometry (pp. 351–352). New York: Wiley. Suche in Google Scholar

[36] Mok, D. K. W., & Chau, F.-T. (2006). Chemical information of Chinese medicines: A challenge to chemist. Chemometrics and Intelligent Laboratory Systems, 82, 210–217. DOI: 10.1016/j.chemolab.2005.05.006. http://dx.doi.org/10.1016/j.chemolab.2005.05.00610.1016/j.chemolab.2005.05.006Suche in Google Scholar

[37] Ni, S.-F., Fu, C.-X., Pan, Y.-J., Lu, Y.-B., Wu, P., & Gilbert, Y. S. (2004). Contrastive analysis of volatile oil from Serissa serissoides in diferent seasons. China Journal of Chinese Materia Medica, 29, 54–58. Suche in Google Scholar

[38] Nicholson, J. K., & Wilson, I. D. (2003). Opinion: understanding “global” systems biology: metabonomics and the continuum of metabolism. Nature Reviews Drug Discovery, 2, 668–676. DOI: 10.1038/nrd1157. http://dx.doi.org/10.1038/nrd115710.1038/nrd1157Suche in Google Scholar

[39] Qin, N. Y., Yang, F. Q., Wang, Y. T., & Li, S. P. (2007). Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 43, 486–492. DOI: 10.1016/j.jpba.2006.07.034. http://dx.doi.org/10.1016/j.jpba.2006.07.03410.1016/j.jpba.2006.07.034Suche in Google Scholar

[40] Ruan, G.-H., & Li, G.-K. (2007). The study on the chromatographic fingerprint of Fructus xanthii by microwave assisted extraction coupled with GC-MS. Journal of Chromatography B, 850, 241–248. DOI: 10.1016/j.jchromb.2006.11.036. http://dx.doi.org/10.1016/j.jchromb.2006.11.03610.1016/j.jchromb.2006.11.036Suche in Google Scholar

[41] Shen, S., Sha, Y., Deng, C., Zhang, X., Fu, D., & Chen, J. (2004). Quality assessment of Flos Chrysanthemi Indici from different growing areas in China by solid-phase microextraction-gas chromatography-mass spectrometry. Journal of Chromatography A, 1047, 281–287. DOI: 10.1016/j.chroma.2004.06.129. 10.1016/S0021-9673(04)01139-2Suche in Google Scholar

[42] Stalikas, C. D. (2007). Extraction, separation, and detection methods for phenolic acids and flavonoids. Journal of Separation Science, 30, 3268–3295. DOI: 10.1002/jssc.200700261. http://dx.doi.org/10.1002/jssc.20070026110.1002/jssc.200700261Suche in Google Scholar PubMed

[43] Taylor, J., King, R. D., Altmann, T., & Fiehn, O. (2002). Application of metabolomics to plant genotype discrimination using statistics and machine learning. Bioinformatics, 18, S241–S248. DOI: 10.1093/bioinformatics/18.suppl_2.S241 10.1093/bioinformatics/18.suppl_2.S241Suche in Google Scholar PubMed

[44] Tyler, V. E. (2000). Herbal medicine: from the past to the future. Public Health Nutrition, 3, 447–452. DOI: 10.1017/S1368980000000525. http://dx.doi.org/10.1017/S136898000000052510.1017/S1368980000000525Suche in Google Scholar PubMed

[45] Wang, H., Dong, X. P., Li, A., & Pan, X. L. (2008). Determination of fatty acids in Livistona chinensis R. Br. Journal of Chengdu University of Traditional Chinese Medicine, 31, 43–44. Suche in Google Scholar

[46] Wang, X., Kapoor, V., & Smythe, G. A. (2003). Extraction and chromatography-mass spectrometric analysis of the active principles from selected Chinese herbs and other medicinal plants. The American Journal of Chinese Medicine, 31, 927–944. DOI: 10.1142/ S0192415X0300165X. http://dx.doi.org/10.1142/S0192415X0300165X10.1142/S0192415X0300165XSuche in Google Scholar PubMed

[47] Wei, Y. S. (2008). The analysis of fatty components from the root of Arctium lappa L. by GC-MS. Food Research and Development, 29, 99–97. Suche in Google Scholar

[48] Wu, Q., Wang, M., & Simon, J. E. (2004). Analytical methods to determine phytoestrogenic compounds. Journal of Chromatography B, 812, 325–355. DOI: 10.1016/j.jchromb.2004. 08.008. Suche in Google Scholar

[49] Xian, H.-M., Zhou, R., Liu, W., & Qin, J.-P. (2008). Determination of the essential oil from different parts of Gynura divaricata (L.) DC. by GC-MS. Lishizhen Medicine and Materia Medica Research, 19, 858–859. Suche in Google Scholar

[50] Xie, G.-X., Qiu, Y.-P., Qiu, M.-F., Gao, X.-F., Liu, Y.-M., & Jia, W. (2007). Analysis of dencichine in Panax notoginseng by gas chromatography-mass spectrometry with ethyl chloroformate derivatization. Journal of Pharmaceutical and Biomedical Analysis, 43, 920–925. DOI: 10.1016/jpba.2006.09.009. http://dx.doi.org/10.1016/j.jpba.2006.09.009Suche in Google Scholar

[51] Xie, P., Chen, S., Liang, Y.-Z., Wang, X., Tian, R., & Upton, R. (2006). Chromatographic fingerprint analysis-a rational approach for quality assessment of traditional Chinese herbal medicine. Journal of Chromatography A, 1112, 171–180. DOI: 10.1016/j.chroma.2005.12.091. http://dx.doi.org/10.1016/j.chroma.2005.12.09110.1016/j.chroma.2005.12.091Suche in Google Scholar PubMed

[52] Ye, D. J. (1998). Science of Chinese medicinal herbs preparation (pp. 16–18). Shanghai: Shanghai Scientific & Technical Publishers. Suche in Google Scholar

[53] Ye, D. J., & Yuan, S. T. (2005). Dictionary of Chinese herbal processing science (pp. 96–97). Shanghai: Shanghai Scientific & Technical Publishers. Suche in Google Scholar

[54] Zhang, H.-B., Tao, Y., Hong, X.-K., & Wang, Z.-H. (2005a). Steriods in musk by gas chromatography/ mass spectrometry. Chinese Traditional Patent Medicine, 27, 79–83. Suche in Google Scholar

[55] Zhang, L. L., Huang, C. Q., & Zhang, Z. Y. (2005b). Analysis of the chemical constituents in the Gelsemium elegans Benth by GC-MS. Journal of Chinese Medicinal Materials, 28, 779–781. Suche in Google Scholar

Published Online: 2009-8-25
Published in Print: 2009-10-1

© 2009 Institute of Chemistry, Slovak Academy of Sciences

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