In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
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Ajay Mishra
,
Shivani Mishra
Abstract
Synthesis, characterization and biological studies of some thiodiamine metal complexes are described. Cobalt(II) and copper(II) complexes of type [Cu(L)2Cl2] and [Co(L)2SO4], where L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2), were synthesized. The synthesized copper and cobalt thiodiamine complexes were characterized by elemental analysis, IR, mass, UV-VIS and 1H NMR spectroscopic studies. Thiodiamines coordinate as a bidentate N-S ligand. The binding sites are azomethine nitrogen and thioamide sulfur. Molar conductance values in dimethylsulfoxide indicate non-electrolyte nature of the complexes. In vitro-antimicrobial screening shows promising results against both bacterial and fungal strains.
[1] Aggarwal, R. C., & Rao, T. R. (1978). Synthesis and structural studies of some first row transition metal complexes of acetone isonicotinoyl hydrazone. Journal of Inorganic and Nuclear Chemistry, 40, 171–174. DOI: 10.1016/0022-1902(78)80334-0. http://dx.doi.org/10.1016/0022-1902(78)80334-010.1016/0022-1902(78)80334-0Search in Google Scholar
[2] Ali, M. A., & Livingstone, S. E. (1974). Metal complexes of sulphur-nitrogen chelating agents. Coordination Chemistry Reviews, 13, 101–132. DOI: 10.1016/S0010-8545(00)80253-2. http://dx.doi.org/10.1016/S0010-8545(00)80253-210.1016/S0010-8545(00)80253-2Search in Google Scholar
[3] Ali, M. A., Mirza, A. H., Butcher, R. J., Tarafder, M. T. H., & Ali, M. A. (2001). Synthetic, spectroscopic, biological and X-ray crystallographic structural studies on a novel pyridine-nitrogen-bridged dimeric nickel(II) complex of a pentadentate N3S2 ligand. Inorganica Chimica Acta, 320, 1–6. DOI: 10.1016/S0020-1693(01)00452-2. http://dx.doi.org/10.1016/S0020-1693(01)00452-210.1016/S0020-1693(01)00452-2Search in Google Scholar
[4] Biswas, G. D, Biswas, P. K., & Chaudhuri, N. R. (1984). Conformational changes of nickel(II) diamine complexes in the solid state. Journal of Chemical Society, Dalton Transactions, 1984, 2591–2598. DOI: 10.1039/DT9840002591. http://dx.doi.org/10.1039/dt9840002591Search in Google Scholar
[5] Choudhary, R. K., Yadav, S. N., Tiwari, H. N., & Mishra, L. K. (1998). Structural aspects of morpholine-N-thiohydrazones complexes with some bivalent metals. Journal of Indian Chemical Society, 75, 392–394. Search in Google Scholar
[6] Eldeen, I. M. S., Elgorashi, E. E., & van Staden, J. (2005). Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine. Journal of Ethnopharmacology, 102, 457–464. DOI: 10.1016/j.jep.2005.08.049. http://dx.doi.org/10.1016/j.jep.2005.08.04910.1016/j.jep.2005.08.049Search in Google Scholar
[7] Kaushik, N. K., & Mishra, A. K. (2003). Synthesis, characterization and thermal studies of some new organotion (iv) complexes with aniline N-thiohydrazide and benzaldehyde aniline N-thiohydrazone ligands. Indian Journal of Chemistry, 42, 2762–2766. Search in Google Scholar
[8] Mishra, A. K., Mishra, S. B., Manav, N., Saluja, D., Chandra, R., & Kaushik, N. K. (2006a). Synthesis, characterization, antibacterial and cytotoxic study of platinum (IV) complexes. Bioorganic and Medicinal Chemistry, 14, 6333–6340. DOI: 10.1016/j.bmc.2006.05.047. http://dx.doi.org/10.1016/j.bmc.2006.05.04710.1016/j.bmc.2006.05.047Search in Google Scholar
[9] Mishra, A. K., Mishra, S. B., Manav, N., & Kaushik, N. K. (2006b). Preparation, spectral characterization, cytotoxic and thermal studies of platinum (IV) thiohydrazone complexes. Journal of Thermal Biology, 31, 611–616. DOI: 10.1016/j.jtherbio.2006.07.003. http://dx.doi.org/10.1016/j.jtherbio.2006.07.00310.1016/j.jtherbio.2006.07.003Search in Google Scholar
[10] Mishra, A. K., & Kaushik, N. K. (2007). Synthesis, characterization, cytotoxicity, antibacterial and antifungal evaluation of some new platinum (IV) and palladium (II) complexes of thiodiamines. European Journal of Medicinal Chemistry, 42, 1239–1246. DOI: 10.1016/j.ejmech.2007.03.017. http://dx.doi.org/10.1016/j.ejmech.2007.03.01710.1016/j.ejmech.2007.03.017Search in Google Scholar
[11] Mishra, A. K., Mishra, S. B., Manav, N., Kumar, R., Sharad, R., Chandra, R., Saluja, D., & Kaushik, N. K. (2007). Platinum(IV) thiohydrazide, thiodiamine and thiohydrazone complexes: A spectral, antibacterial and cytotoxic study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 66, 1042–1047. DOI: 10.1016/j.saa.2006.04.038. http://dx.doi.org/10.1016/j.saa.2006.04.03810.1016/j.saa.2006.04.038Search in Google Scholar
[12] Padhyé, S., & Kauffman, G. B. (1985). Transition metal complexes of semicarbazones and thiosemicarbazones. Coordination Chemistry Reviews, 63, 127–160. DOI: 10.1016/0010-8545(85)80022-9. http://dx.doi.org/10.1016/0010-8545(85)80022-910.1016/0010-8545(85)80022-9Search in Google Scholar
[13] Rajesh, & Sharma, G. L. (2002). Studies on antimycotic properties of Datura metal. Journal of Ethnopharmacology, 80, 193–197. DOI: 10.1016/S0378-8741(02)00036-3. http://dx.doi.org/10.1016/S0378-8741(02)00036-310.1016/S0378-8741(02)00036-3Search in Google Scholar
[14] Singh, N. K., Srivastava, A., Sodhi, A., & Ranjan, P. (2000). In vitro and in vivo antitumour studies of a new thiosemicarbazide derivative and its complexes with 3d-metal ions. Transition Metal Chemistry, 25, 133–140. DOI: 10.1023/A:1007081218000. http://dx.doi.org/10.1023/A:100708121800010.1023/A:1007081218000Search in Google Scholar
[15] West, D. X., Nassar, A. A., El-Saied, F. A., & Ayad, M. I. (1999). Cobalt(II) complexes with 2-aminoacetophenone N(4)-substituted thiosemicarbazones. Transition Metal Chemistry, 24, 617–621. DOI: 10.1023/A:1006988320142. http://dx.doi.org/10.1023/A:100698832014210.1023/A:1006988320142Search in Google Scholar
© 2009 Institute of Chemistry, Slovak Academy of Sciences
Articles in the same Issue
- Magnetic nano- and microparticles in biotechnology
- Application of gas chromatography-mass spectrometry in research of traditional Chinese medicine
- Copper determination using ICP-MS with hexapole collision cell
- Reactivation of a palladium catalyst during glucose oxidation by molecular oxygen
- Robust stabilization of a chemical reactor
- Influence of production progress on the heavy metal content in flax fibers
- In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
- Synthesis, characterization, and antimicrobial activity of new benzoylthiourea ligands
- Investigation of DNA cleavage activities of new oxime-type ligand complexes and molecular modeling of complex-DNA interactions
- Characterization of mechanochemically synthesized lead selenide
- Hydroxyapatite modified with silica used for sorption of copper(II)
- Corrosion resistance of zinc electrodeposited from acidic and alkaline electrolytes using pulse current
- Ternary composites of multi-wall carbon nanotubes, polyaniline, and noble-metal nanoparticles for potential applications in electrocatalysis
- Synthesis of 2-[3-(trifluoromethyl)phenyl]furo[3,2-c]pyridine derivatives
- Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group
- Comparative DFT study on the α-glycosidic bond in reactive species of galactosyl diphosphates
- Gas chromatographic retention times prediction for components of petroleum condensate fraction
- Gas chromatography with surface ionization detection of nitro pesticides
- Clean fuel-oriented investigation of thiophene oxidation by hydrogen peroxide using polyoxometalate as catalyst
- Aqueous foam stabilized by polyoxyethylene dodecyl ether
Articles in the same Issue
- Magnetic nano- and microparticles in biotechnology
- Application of gas chromatography-mass spectrometry in research of traditional Chinese medicine
- Copper determination using ICP-MS with hexapole collision cell
- Reactivation of a palladium catalyst during glucose oxidation by molecular oxygen
- Robust stabilization of a chemical reactor
- Influence of production progress on the heavy metal content in flax fibers
- In vitro antifungal and antibacterial properties of thiodiamine transition metal complexes
- Synthesis, characterization, and antimicrobial activity of new benzoylthiourea ligands
- Investigation of DNA cleavage activities of new oxime-type ligand complexes and molecular modeling of complex-DNA interactions
- Characterization of mechanochemically synthesized lead selenide
- Hydroxyapatite modified with silica used for sorption of copper(II)
- Corrosion resistance of zinc electrodeposited from acidic and alkaline electrolytes using pulse current
- Ternary composites of multi-wall carbon nanotubes, polyaniline, and noble-metal nanoparticles for potential applications in electrocatalysis
- Synthesis of 2-[3-(trifluoromethyl)phenyl]furo[3,2-c]pyridine derivatives
- Key side products due to reactivity of dimethylmaleoyl moiety as amine protective group
- Comparative DFT study on the α-glycosidic bond in reactive species of galactosyl diphosphates
- Gas chromatographic retention times prediction for components of petroleum condensate fraction
- Gas chromatography with surface ionization detection of nitro pesticides
- Clean fuel-oriented investigation of thiophene oxidation by hydrogen peroxide using polyoxometalate as catalyst
- Aqueous foam stabilized by polyoxyethylene dodecyl ether
