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Comprehensive review of metal-based coordination compounds in cancer therapy: from design to biochemical reactivity

  • Peshang Khdir Omer , Nazk M. Aziz and Rebaz Anwar Omer ORCID logo EMAIL logo
Published/Copyright: August 8, 2024
Reviews in Inorganic Chemistry
From the journal Reviews in Inorganic Chemistry Volume 44 Issue 4

Abstract

Throughout history, metal-based coordination compounds have been used for medical purposes, including the treatment of various illnesses like cancer. Since the discovery of cisplatin in 1965, many other metal coordinating complexes have been developed and evaluated, involving metals such as platinum, iron, zinc, ruthenium, gold, silver, titanium, and copper. The goal behind these efforts is to create effective and safe medications. At the moment, there are a lot of studies talking about the use of cytostatic metal complexes, mainly on promising platinum- and non-platinum-based drugs in both preclinical and clinical trials. However, there is a lack of recent comprehensive studies that cover both the chemical and biological aspects of metal-based coordinating molecules in the context of cancer therapy. This review aims to provide a thorough analysis of the coordination chemistry of existing and innovative cytostatic substances. It will include a description of their design and synthesis, as well as a summary of the biochemical reactivity and physicochemical features of potential metal-containing complexes.

Keywords: cisplatin; cancer; metal coordinating complexes; gold and silver
Corresponding author: Rebaz Anwar Omer, Department of Chemistry, Faculty of Science & Health, Koya University, KOY45, Kurdistan Region – F. R, Koya, Iraq; and Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil 44001, Iraq, E-mail:

  1. Research ethics: Not applicable.

  2. Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: The authors state no conflict of interest.

  4. Research funding: None declared.

  5. Data availability: Not applicable.

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Received: 2024-05-17
Accepted: 2024-07-22
Published Online: 2024-08-08
Published in Print: 2024-11-26

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/revic-2024-0030
Keywords for this article
cisplatin; cancer; metal coordinating complexes; gold and silver

Articles in the same Issue

  1. Frontmatter
  2. Unveiling the multifaceted roles of protonated 1,2-bis(4-pyridyl)ethylene (HBpe+) ligand in metal-driven supramolecular assembly: a comprehensive structural review
  3. Advanced synthetic routes of metal organic frameworks and their diverse applications
  4. Carbon materials derived by crystalline porous materials for capacitive energy storage
  5. BiVO4-based heterojunction nanophotocatalysts for water splitting and organic pollutant degradation: a comprehensive review of photocatalytic innovation
  6. Synthesis, characterization, thermal, theoretical studies, antimicrobial, antioxidant activity, superoxide dismutase-like activity and catalase mimetics of metal(II) complexes derived from sugar and Schiff base
  7. Solid-phase extraction of organophosphates from polluted waters on a matrix-imprinted sorbent
  8. Reduction mechanism and energy transfer between Eu3+ and Eu2+ in Eu-doped materials synthesized in air atmosphere
  9. Green synthesis and applications of mono/bimetallic nanoparticles on mesoporous clay: a review
  10. Hydroxyapatite biomaterials: a comprehensive review of their properties, structures, clinical applications, and producing techniques
  11. Water desalination, and energy consumption applications of 2D nano materials: hexagonal boron nitride, graphenes, and quantum dots
  12. Transformative applications of “click” chemistry in the development of MOF architectures − a mini review
  13. A review of carbon-based adsorbents for the removal of organic and inorganic components
  14. Mercury removal from water: insights from MOFs and their composites
  15. Organometallic complexes and reaction methods for synthesis: a review
  16. Comprehensive review of metal-based coordination compounds in cancer therapy: from design to biochemical reactivity
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