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Five X-chromosome short tandem repeats in a Western Mexican population
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Yeminia Valle
Veröffentlicht/Copyright:
1. Oktober 2008
Abstract
Background: X-linked microsatellites represent an efficient complement of autosomal and Y-chromosomal markers in forensic and kinship analysis.
Methods: DXS337 (n=208), DXS101 (n=208), HPRTB (n=206), DXS8377 (n=220), and DXS7423 (n=213) were genotyped in male and female samples from a Western Mexican Mestizo population using singleplex systems and polyacrylamide gel electrophoresis.
Results: Genotype distributions did not deviate from Hardy-Weinberg expectations, and pairwise allele combination analysis was consistent with independent segregation for every marker (p>0.05). Allele frequencies were not different by gender. Differences in allele distribution with respect to Caucasian population data (DXS101, HPRTB, DXS8377, DXS7423) seem attributable to the native Mexican component. For the set of five markers, the combined power of discrimination and the probability of exclusion in paternity tests in trios were greater than 0.999.
Conclusions: The present data reveal that the panel of five X-short tandem repeats analyzed is highly informative in forensic identity and parentage studies in Western Mexico.
Clin Chem Lab Med 2008;46:1388–90.
Received: 2008-2-25
Accepted: 2008-6-4
Published Online: 2008-10-01
Published in Print: 2008-10-01
©2008 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
DNA typing;
forensic analysis;
Mexican population;
X-linked short tandem repeats
Artikel in diesem Heft
- Review
- Use of biochemical markers of bone turnover in the management of postmenopausal osteoporosis
- Minireview
- Is serum procalcitonin able to predict long-term kidney morbidity from urinary tract infections in children?
- Genetics and Molecular Diagnostics
- Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients
- Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects
- New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia
- Enzyme-free signal amplification of analyte in a single closed tube by fluorescent hybridization chain reaction
- Five X-chromosome short tandem repeats in a Western Mexican population
- General Clinical Chemistry and Laboratory Medicine
- Prolyl-hydroxyproline dipeptide in non-hydrolyzed morning urine and its value in postmenopausal osteoporosis
- Methionine metabolism in an animal model of sepsis
- Hypochlorous acid is a potent inactivator of human plasminogen at concentrations secreted by activated granulocytes
- Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults
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- The relationship between usual coffee consumption and serum C-reactive protein level in a Japanese female population
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- Analytical quality goals for parathyroid hormone based on biological variation
- Preanalytical effects of pneumatic tube transport on routine haematology, coagulation parameters, platelet function and global coagulation
- Validation and Outcome Studies
- Automated immunoassay methods for ferritin: recovery studies to assess traceability to an international standard
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