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Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults
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Yong-Jae Lee
Published/Copyright:
October 1, 2008
Abstract
Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation.
Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95% confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT.
Results: Results for the OR (95% CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21–2.29), 2.10 (1.51–2.93) and 2.51 (1.81–3.60) in men, and 1.00, 1.05 (0.65–1.68), 1.45 (0.79–2.02) and 2.16 (1.37–3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed.
Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.
Clin Chem Lab Med 2008;46:1410–5.
Keywords: cardiovascular disease; C-reactive protein; γ-glutamyltransferase; inflammation; white blood cell count
Received: 2008-3-4
Accepted: 2008-6-3
Published Online: 2008-10-01
Published in Print: 2008-10-01
©2008 by Walter de Gruyter Berlin New York
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Keywords for this article
cardiovascular disease;
C-reactive protein;
γ-glutamyltransferase;
inflammation;
white blood cell count
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- Minireview
- Is serum procalcitonin able to predict long-term kidney morbidity from urinary tract infections in children?
- Genetics and Molecular Diagnostics
- Association between the 2756A> G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients
- Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects
- New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia
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