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Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
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Cynthia M. Balion
Veröffentlicht/Copyright:
1. September 2007
Abstract
Background: The classifications of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) represent glucose levels above normal, but below the decision threshold for diabetes. We sought to determine what the reproducibility of these classifications was when repeat tests were performed by conducting a systematic review of the literature.
Methods: All primary studies published in English of any study design were included. Studies were excluded if they did not follow the World Health Organization or American Diabetes Association diagnostic criteria, used whole blood as the specimen type, a glucose meter for analysis, or performed repeat testing greater than 8 weeks apart.
Results: Five papers had reproducibility data for IGT or IFG, two of which where from the same population but sampled differently. The κ coefficients, indicating agreement between repeat tests that exceeded chance, indicated poor to fair agreement for IGT (0.04, 0.22, 0.38, 0.42) and moderate agreement for IFG (0.44 and 0.56). Similarly, the observed reproducibility was slightly lower for IGT (33%, 44%, 47%, 48%) compared to IFG (51%, 64%). In two studies for which data were available for both IGT and IFG, the average reproducibility was lower (49%) for the prediabetes group compared to the diabetes group (73%) or the normal group (93%).
Conclusions: Poor reproducibility of IGT and IFG classification suggests caution should be exercised when interpreting a single test result.
Clin Chem Lab Med 2007;45:1180–5.
Keywords: classification; diagnosis; impaired fasting glucose; impaired glucose tolerance; reproducibility; systematic review
Received: 2007-3-7
Accepted: 2007-5-14
Published Online: 2007-09-01
Published in Print: 2007-09-01
©2007 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
classification;
diagnosis;
impaired fasting glucose;
impaired glucose tolerance;
reproducibility;
systematic review
Artikel in diesem Heft
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
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- New perspectives and strategy research biomarkers for hepatocellular carcinoma
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- Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
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- Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
- Intra-individual variation in creatinine and cystatin C
- Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
- An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
- Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
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