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The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
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Kazuhiko Kotani
Published/Copyright:
September 11, 2007
Abstract
Background: The possible effects of the uncoupling protein-1 (UCP-1) gene −3826A/G polymorphism on hypertension (HT) have yet to be elucidated.
Methods: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the −3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.
Results: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs. GG) and other covariates such as cardiovascular risk factors [e.g., smoking, body mass index (BMI), dyslipidemia and diabetes] showed age [odds ratio (OR) 1.11 (95% confidence interval 1.08–1.13)] and BMI [OR 1.13 (1.06–1.21)] as independent significant factors. In the subgroup analysis, as well as age and BMI, GG genotype [OR 2.32 (1.08–4.99)] was also an independent significant factor for HT in males. Similarly, as well as age and BMI, GG genotype [OR 1.89 (1.00–3.57)] was also an independent significant factor for HT in the relatively older subgroup (≥60 years).
Conclusions: The results suggest that the GG genotype may be associated with the presence of HT in Japanese males and older subjects. Further investigation is needed to confirm our hypothesis.
Clin Chem Lab Med 2007;45:1186–9.
Received: 2007-3-1
Accepted: 2007-5-4
Published Online: 2007-09-11
Published in Print: 2007-09-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
blood pressure;
elderly;
gender;
hypertension;
single nucleotide polymorphisms (SNPs)
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- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
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