Artikel
Lizenziert
Nicht lizenziert
Erfordert eine Authentifizierung
The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
-
Kazuhiko Kotani
Veröffentlicht/Copyright:
11. September 2007
Abstract
Background: The possible effects of the uncoupling protein-1 (UCP-1) gene −3826A/G polymorphism on hypertension (HT) have yet to be elucidated.
Methods: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the −3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods.
Results: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs. GG) and other covariates such as cardiovascular risk factors [e.g., smoking, body mass index (BMI), dyslipidemia and diabetes] showed age [odds ratio (OR) 1.11 (95% confidence interval 1.08–1.13)] and BMI [OR 1.13 (1.06–1.21)] as independent significant factors. In the subgroup analysis, as well as age and BMI, GG genotype [OR 2.32 (1.08–4.99)] was also an independent significant factor for HT in males. Similarly, as well as age and BMI, GG genotype [OR 1.89 (1.00–3.57)] was also an independent significant factor for HT in the relatively older subgroup (≥60 years).
Conclusions: The results suggest that the GG genotype may be associated with the presence of HT in Japanese males and older subjects. Further investigation is needed to confirm our hypothesis.
Clin Chem Lab Med 2007;45:1186–9.
Received: 2007-3-1
Accepted: 2007-5-4
Published Online: 2007-09-11
Published in Print: 2007-09-01
©2007 by Walter de Gruyter Berlin New York
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Sie haben derzeit keinen Zugang zu diesem Inhalt.
Artikel in diesem Heft
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
- Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
- New perspectives and strategy research biomarkers for hepatocellular carcinoma
- Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
- The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
- Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
- Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
- Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
- Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
- The association between lipid profiles and breast cancer among Taiwanese women
- Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
- Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
- Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
- Intra-individual variation in creatinine and cystatin C
- Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
- An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
- Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
- Type B natriuretic peptide stability in frozen plasma
Schlagwörter für diesen Artikel
blood pressure;
elderly;
gender;
hypertension;
single nucleotide polymorphisms (SNPs)
Artikel in diesem Heft
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
- Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
- New perspectives and strategy research biomarkers for hepatocellular carcinoma
- Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
- The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
- Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
- Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
- Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
- Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
- The association between lipid profiles and breast cancer among Taiwanese women
- Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
- Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
- Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
- Intra-individual variation in creatinine and cystatin C
- Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
- An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
- Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
- Type B natriuretic peptide stability in frozen plasma
