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The association between lipid profiles and breast cancer among Taiwanese women
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Shun-Jen Chang
Published/Copyright:
September 11, 2007
Abstract
Background: Breast cancer incidence increased seven-fold from 1979 to 2002, and it has become the second most common cancer in Taiwanese women. Although the relationship between high-density lipoprotein cholesterol (HDL-C) and breast cancer has been studied, no consistent association has been explicitly confirmed. The aim of this study was to demonstrate the relationship between breast cancer and lipid profiles in Taiwanese women.
Methods: A total of 150 breast cancer patients before treatment and 71 healthy controls were enrolled. Lipid profiles in fasting serum were measured after participants gave their consent.
Results: The breast cancer patients had significantly lower values for HDL-C and apolipoprotein A-I (apoA-I), lower apoA-I/apoB ratios and higher values for very-low-density lipoprotein cholesterol (VLDL-C) than controls. After logistic regression analysis, the breast cancer patients had significantly higher values for VLDL-C and lower values for apoA-I after controlling for HDL-C and the apoA-I/apoB ratio.
Conclusions: Our findings demonstrate that higher VLDL-C and lower apoA-I values were significantly associated with breast cancer, with a greater association between apoA-I values and the development of breast cancer than for HDL-C values.
Clin Chem Lab Med 2007;45:1219–23.
Received: 2007-3-20
Accepted: 2007-5-21
Published Online: 2007-09-11
Published in Print: 2007-09-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
apolipoprotein;
breast cancer;
lipid profiles;
very-low-density lipoprotein cholesterol
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- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
- Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
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