Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
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Loredan Stefan Niculescu
Abstract
Background: Genetic variation at the apolipoprotein A-V locus, recently discovered proximal to the APOA1/C3/A4 gene cluster, is associated with elevated triglyceride concentrations, a risk factor for atherosclerosis.
Methods: The goal of our study was to determine the association of two apolipoprotein A-V (APOA5) gene polymorphisms in a group of urban Romanian subjects with the prevalence of the metabolic syndrome. For this purpose, we assayed −1.131T>C and c.56C>G polymorphisms for 279 subjects divided into three groups: a control group, a metabolic syndrome group and a cardiovascular disease group. Then we correlated the minor allele frequencies with body mass index and biochemical parameters.
Results: We obtained higher frequency for −1.131C compared to c.56G alleles, both mainly distributed in overweight subjects. Body mass index and triglyceride levels were higher in −1.131C allele carriers in metabolic syndrome patients, but were not significantly different in c.56G carriers compared to those with the native gene. Metabolic syndrome −1.131C homozygotes presented lower high-density lipoprotein cholesterol and higher glucose levels compared to subjects with the native gene. Total cholesterol, low-density lipoprotein cholesterol and insulin were not different between −1.131C or c.56G allele carriers and those with the native gene.
Conclusions: Our results demonstrate an independent risk for −1.131T>C APOA5 gene polymorphisms in the development of metabolic syndrome.
Clin Chem Lab Med 2007;45:1133–9.
©2007 by Walter de Gruyter Berlin New York
Artikel in diesem Heft
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
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Artikel in diesem Heft
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
- Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
- New perspectives and strategy research biomarkers for hepatocellular carcinoma
- Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
- The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
- Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
- Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
- Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
- Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
- The association between lipid profiles and breast cancer among Taiwanese women
- Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
- Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
- Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
- Intra-individual variation in creatinine and cystatin C
- Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
- An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
- Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
- Type B natriuretic peptide stability in frozen plasma
