Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
-
Christian Murr
Abstract
Background: As a component of the enzyme glutathione peroxidase, the essential trace element selenium contributes to the reduction of peroxides. Disturbed selenium availability may relate to an activated immune response. In humans, immune activation is reflected by increased neopterin production and accelerated tryptophan degradation, expressed as the kynurenine to tryptophan ratio (kyn/trp). Th1-type cytokine interferon-γ induces both these immunobiological events in human macrophages and they are often activated in patients with cardiac disorders. The aim of this study was to determine the relationship between serum selenium concentrations and neopterin production and tryptophan degradation in patients with cardiac disorders.
Methods: In 56 patients (28 females) with cardiac disorders, serum selenium concentrations were determined by graphite-furnace atomic absorption spectrometry. Serum neopterin concentration was measured by ELISA and tryptophan degradation was examined by HPLC.
Results: Selenium concentrations were in the range 0.41–1.90 μmol/L (median 1.02) and were well within the local normal range. Approximately two-thirds of patients presented with higher neopterin concentrations (median 16.4 nmol/L) and tryptophan degradation (median 57 μmol/mmol kyn/trp). There was an inverse correlation between serum selenium and kyn/trp (Spearman's rank correlation, rs=−0.431; p<0.001) and neopterin concentrations (rs=−0.300; p<0.05). Neopterin concentrations correlated strongly with kyn/trp (rs=0.712; p<0.0001).
Conclusions: A higher degree of tryptophan degradation and of neopterin production in patients with cardiac disorders coincides with lower, albeit still normal, serum selenium concentrations. Data show that in these patients immune activation is associated with lower serum selenium concentrations.
Clin Chem Lab Med 2007;45:1224–8.
©2007 by Walter de Gruyter Berlin New York
Articles in the same Issue
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
- Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
- New perspectives and strategy research biomarkers for hepatocellular carcinoma
- Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
- The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
- Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
- Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
- Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
- Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
- The association between lipid profiles and breast cancer among Taiwanese women
- Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
- Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
- Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
- Intra-individual variation in creatinine and cystatin C
- Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
- An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
- Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
- Type B natriuretic peptide stability in frozen plasma
Articles in the same Issue
- SIBioC 2007, 39th National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, Palacongressi Rimini (Italy), 2-5 October 2007
- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
- Prothrombogenic factors and reduced antioxidative defense in children and adolescents with pre-metabolic and metabolic syndrome
- Interleukin-6 gene promoter –174G/C polymorphism and insulin resistance: a pilot study
- Apolipoprotein E polymorphism – a risk factor for metabolic syndrome
- Peripheral blood mononuclear cells (PBMCs): a possible model for studying cardiovascular biology systems
- New perspectives and strategy research biomarkers for hepatocellular carcinoma
- Reproducibility of impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) classification: a systematic review
- The uncoupling protein-1 gene −3826A/G polymorphism and hypertension in Japanese subjects
- Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
- Histamine induces the expression of uncoupling protein 2 (UCP2) and acid-binding protein (aP2) in white adipocytes
- Biochemical and clinical correlates of hypouricemia in surgical and critically ill patients
- Reliability of oxidative stress biomarkers in hemodialysis patients: a comparative study
- The association between lipid profiles and breast cancer among Taiwanese women
- Inverse association between serum selenium concentrations and parameters of immune activation in patients with cardiac disorders
- Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects
- Sources of variation and reference intervals for serum cystatin C in a healthy Japanese adult population
- Intra-individual variation in creatinine and cystatin C
- Gammopathy interference in clinical chemistry assays: mechanisms, detection and prevention
- An Italian program of External Quality Control for chromogranin A (CgA) assay: performance evaluation of CgA determination
- Automated urinalysis: first experiences and a comparison between the Iris iQ200 urine microscopy system, the Sysmex UF-100 flow cytometer and manual microscopic particle counting
- Type B natriuretic peptide stability in frozen plasma
