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Intra-individual variation in creatinine and cystatin C
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Niluka Bandaranayake
Published/Copyright:
September 11, 2007
Abstract
Background: Serum creatinine and cystatin C are measured in the assessment of glomerular filtration rate. Biological variation of an analyte is an important determinant of its usefulness. Intra-individual variation in serum creatinine and cystatin C in healthy subjects was determined in this study.
Methods: Weekly blood samples were taken from 10 healthy subjects and analysed for creatinine (kinetic Jaffe method) and for cystatin C (by nephelometry).
Results: Intra-individual variations for serum creatinine and cystatin C were 6.1% and 4.55%, respectively. Index of individuality values were similar for the analytes (0.35 for both).
Conclusion: Intra-individual variations for serum creatinine and cystatin C were similar in healthy subjects.
Clin Chem Lab Med 2007;45:1237–9.
Received: 2007-3-26
Accepted: 2007-5-14
Published Online: 2007-09-11
Published in Print: 2007-09-01
©2007 by Walter de Gruyter Berlin New York
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Keywords for this article
creatinine;
cystatin C;
glomerular filtration rate;
intra-individual variation
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