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Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia
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Genovefa Kolovou
Published/Copyright:
September 1, 2007
Abstract
Background: We examined the influence of cholesteryl ester transfer protein TaqIB polymorphism on triglyceride (TG) response to an oral fat tolerance test (OFTT) in patients heterozygous for familial hypercholesterolemia (hFH).
Methods: We genotyped 67 hFH patients (32 men and 35 postmenopausal women) who were subjected to an OFTT.
Results: All B1 allele carriers had lower high-density lipoprotein cholesterol (HDL-C) levels (p=0.013) and higher postprandial TG response at 6 and 8 h (p=0.05 and p=0.04, respectively) compared to B2 allele carriers. Multiple regression analysis showed that in the hFH group with a positive response, the presence of the B2 allele was significantly related to lower levels of TG-area under the curve (AUC) (p<0.01) compared to B1, adjusting for age, gender and body mass index. In the hFH group with a negative response, although age and female gender had a significant effect on TG-AUC levels (p<0.01 for both), the allele type was not significantly related to the TG-AUC levels (p=0.99).
Conclusions: B2 carriers had a lower postprandial TG response compared to B1 carriers. There were no differences in TG levels between B1 and B2 carriers in patients with a negative OFTT response. Therefore, at higher TG concentration, the B2 allele may protect against an exaggerated postprandial TG increase and subsequent lowering of HDL-C.
Clin Chem Lab Med 2007;45:1190–8.
Keywords: atherosclerosis; cholesteryl ester transfer protein; familial hypercholesterolemia; high-density lipoprotein cholesterol; postprandial hypertriglyceridemia; TaqIB polymorphism
Received: 2007-2-1
Accepted: 2007-5-21
Published Online: 2007-09-01
Published in Print: 2007-09-01
©2007 by Walter de Gruyter Berlin New York
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- Third “Biologie Prospective” Santorini Conference
- Application of leukocyte transcriptomes to assess systemic consequences of risk factors for cardiovascular disease
- Ghrelin variants influence development of body mass index and plasma levels of total cholesterol in dialyzed patients
- Evaluation of genetic predisposition to insulin resistance by nutrient-induced insulin output ratio (NIOR)
- Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
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