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HPLC analysis of a syrup containing nimesulide and its hydrolytic degradation product

  • Milan Mokrý EMAIL logo , Jiří Klimeš und Jana Pechová
Veröffentlicht/Copyright: 31. März 2010
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Chemical Papers
Aus der Zeitschrift Chemical Papers Band 64 Heft 3

Abstract

The present paper deals with the evaluation of nimesulide, 2-phenoxy-4-nitroaniline, the main hydrolytic degradation product of nimesulide, of methylparaben and propylparaben, and eventually of 4-hydroxybenzoic acid by HPLC with UV detection at 254 nm in syrup as a pharmaceutical formulation. HPLC analysis was employed on the reversed phase C18 with methanol and 0.01 M dibasic ammonium phosphate (ρ r = 60: 40, pH 4.0). Validation was performed using standards and a pharmaceutical preparation containing the compounds described above.

Keywords: nimesulide; degradation product; pharmaceutical formulation; HPLC

[1] Altinöz, S., & Dursun, Ö. Ö. (2000). Determination of nimesulide in pharmaceutical dosage forms by second order derivative UV spectrophotometry. Journal of Pharmaceutical and Biomedical Analysis, 22, 175–182. DOI: 10.1016/S0731-7085(99)00264-2. http://dx.doi.org/10.1016/S0731-7085(99)00264-210.1016/S0731-7085(99)00264-2Suche in Google Scholar

[2] Carini, M., Aldini, G., Stefani, R., Marinello, C., & Facino, R. M. (1998). Mass spectrometric characterization and HPLC determination of the main urinary metabolites of nimesulide in man. Journal of Pharmaceutical and Biomedical Analysis, 18, 201–211. DOI: 10.1016/S0731-7085(98)00172-1. http://dx.doi.org/10.1016/S0731-7085(98)00172-110.1016/S0731-7085(98)00172-1Suche in Google Scholar

[3] Carlucci, G. (2009). Analytical procedure for determination of cyclooxygenase-2 inhibitors in biological fluids by high performance liquid chromatography: a review. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 8, 22–37. DOI: 10.2174/187152309787580829. http://dx.doi.org/10.2174/18715230978758082910.2174/187152309787580829Suche in Google Scholar

[4] Chandran, S., Ravi, P., Jadhav, P. R., & Saha, R. N. (2008). A simple, rapid, and validated LC method for the estimation of nimesulide in human serum and its application in bioavailability studies. Analytical Letters, 41, 2437–2451. DOI: 10.1080/00032710802352480. http://dx.doi.org/10.1080/0003271080235248010.1080/00032710802352480Suche in Google Scholar

[5] European Directorate for the Quality of Medicines (EDQM) (2007). European pharmacopoeia (6th ed., pp. 2506–2507). Strasbourg, France: Council of Europe. Suche in Google Scholar

[6] Facino, R. M., Carini, M., & Aldini, G. (1993). Antioxidant activity of nimesulide and its main metabolites. Drugs, 46(Suppl. 1), 15–21. http://dx.doi.org/10.2165/00003495-199300461-0000510.2165/00003495-199300461-00005Suche in Google Scholar

[7] Ferrario, P., & Bianchi, M. (2003). Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction. Journal of Chromatography B, 785, 227–236. DOI: 10.1016/S1570-0232(02)00857-7. http://dx.doi.org/10.1016/S1570-0232(02)00857-710.1016/S1570-0232(02)00857-7Suche in Google Scholar

[8] Glachetti, C., & Tenconi, A. (1998). Determination of nimesulide and hydroxynimesulide in human plasma by high performance liquid chromatography. Biomedical Chromatography, 12, 50–56. DOI: 10.1002/(SICI)1099-0801(199803/04)12:2<50::AID-BMC719>3.0.CO;2-B. http://dx.doi.org/10.1002/(SICI)1099-0801(199803/04)12:2<50::AID-BMC719>3.0.CO;2-B10.1002/(SICI)1099-0801(199803/04)12:2<50::AID-BMC719>3.0.CO;2-BSuche in Google Scholar

[9] Khaksa, G., & Udupa, N. (1999). Rapid and sensitive method for determination of nimesulide in human plasma by high-performance liquid chromatography. Journal of Chromatography B, 727, 241–244. DOI: 10.1016/S0378-4347(98)00567-2. http://dx.doi.org/10.1016/S0378-4347(98)00567-210.1016/S0378-4347(98)00567-2Suche in Google Scholar

[10] Kovaříková, P., Mokrý, M., & Klimeš, J. (2003). Photochemical stability of nimesulide. Journal of Pharmaceutical and Biomedical Analysis, 31, 827–832. DOI: 10.1016/S0731-7085(02)00659-3. http://dx.doi.org/10.1016/S0731-7085(02)00659-310.1016/S0731-7085(02)00659-3Suche in Google Scholar

[11] Maltese, A., Maugeri, F., & Bucolo, C. (2004). Rapid determination of nimesulide in rabbit aqueous humor by liquid chromatography. Journal of Chromatography B, 804, 441–443. DOI: 10.1016/j.jchromb.2004.01.058. http://dx.doi.org/10.1016/j.jchromb.2004.01.05810.1016/j.jchromb.2004.01.058Suche in Google Scholar

[12] Nagaralli, B. S., Seetharamappa, J., Gowda, B. G., & Melwanki, M. B. (2003). High-performance liquid chromatographic method for the determination of nimesulide in pharmaceutical preparations. Journal of Analytical Chemistry, 58, 778–780. DOI: 10.1023/A:1025095829622. http://dx.doi.org/10.1023/A:102509582962210.1023/A:1025095829622Suche in Google Scholar

[13] Pandya, K. K., Satia, M. C., Modi, I. A., Modi, R. I., Chakravarthy, B. K., & Gandhi, T. P. (1997). High-performance thin-layer chromatography for the determination of nimesulide in human plasma and its use in pharmacokinetic studies. Journal of Pharmacy and Pharmacology, 49, 773–776. Suche in Google Scholar

[14] Rao, R. N., Meena, S., Nagaraju, D., & Rao, A. R. R. (2005). Development and validation of a reversed-phase liquid chromatographic method for separation and simultaneous determination of COX-2 inhibitors in pharmaceuticals and its application to biological fluids. Biomedical Chromatography, 19, 362–368. DOI: 10.1002/bmc.458. http://dx.doi.org/10.1002/bmc.45810.1002/bmc.458Suche in Google Scholar PubMed

[15] Tubić, B., Ivković, B., Zečević, M., & Vladimirov, S. (2007). Simultaneous determination of nimesulide and its impurities in pharmaceutical formulations by reversed-phase high-performance liquid chromatography. Acta Chimica Slovenica, 54, 583–590. Suche in Google Scholar

[16] Van Antwerpen, P., & Nève, J. (2004). In vitro comparative assessment of the scavenging activity against three reactive oxygen species of non-steroidal anti-inflammatory drugs from the oxicam and sulfoanilide families. European Journal of Pharmacology, 496, 55–61. DOI: 10.1016/j.ejphar.2004.06.017. http://dx.doi.org/10.1016/j.ejphar.2004.06.01710.1016/j.ejphar.2004.06.017Suche in Google Scholar PubMed

[17] Wang, C., Shao, X., Liu, Q., Qu, Q., Yang, G., & Hu, X. (2006). Differential pulse voltametric determination of nimesulide in pharmaceutical formulation and human serum at glassy carbon electrode modified by cysteic acid/CNTs base on electrochemical oxidation of L-cysteine. Journal of Pharmaceutical and Biomedical Analysis, 42, 237–244. DOI: 10.1016/j.jpba.2006.03.038. http://dx.doi.org/10.1016/j.jpba.2006.03.03810.1016/j.jpba.2006.03.038Suche in Google Scholar PubMed

Published Online: 2010-3-31
Published in Print: 2010-6-1

© 2009 Institute of Chemistry, Slovak Academy of Sciences

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https://doi.org/10.2478/s11696-010-0001-2
Schlagwörter für diesen Artikel
nimesulide; degradation product; pharmaceutical formulation; HPLC

Artikel in diesem Heft

  1. A proposal of reference values for relative uncertainty increase in spectrophotometric analysis of pharmaceutical formulations
  2. Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes
  3. A simple turbidimetric flow injection system for saccharin determination in sweetener products
  4. Determination of metoprolol tartrate by capillary isotachophoresis
  5. Model predictive control of a CSTR: A hybrid modeling approach
  6. Application of extended NRTL equation for ternary liquid-liquid and vapor-liquid-liquid equilibria description
  7. Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base
  8. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 4-cyanopyridine Cu4OBrnCl(6−n)(4-CNpy)4 complexes
  9. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 3-cyanopyridine Cu4OBrnCl(6−n)(3-CNpy)4 complexes
  10. Deposition and release of chlorhexidine from non-ionic and anionic polymer matrices
  11. Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
  12. Spectroscopic characterization of halogen- and cyano-substituted pyridinevinylenes synthesized without catalyst or solvent
  13. Chemical composition and antimicrobial activity of Erodium species: E. ciconium L., E. cicutarium L., and E. absinthoides Willd. (Geraniaceae)
  14. Photo-Fenton and photo-Fenton-like processes for the degradation of methyl orange in aqueous medium: Influence of oxidation states of iron
  15. Voltammetry of resazurin at a mercury electrode
  16. Effect of dielectric medium on angiotensin converting enzyme inhibitors binding to Zn2+
  17. HPLC analysis of a syrup containing nimesulide and its hydrolytic degradation product
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