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Determination of metoprolol tartrate by capillary isotachophoresis

  • Marzanna Kurzawa EMAIL logo
Published/Copyright: March 31, 2010
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Chemical Papers
From the journal Chemical Papers Volume 64 Issue 3

Abstract

This paper describes two isotachophoretic methods of metoprolol tartrate (MT) determination in pure and dosage forms. The first method was used for direct analysis where the following electrolyte system was applied: 10 mmol dm−3 3-morpholino-2-hydroxypropanesulfonic acid, 10 mmol dm−3 NaCl, 2 % hydroxyethylocelulose as leading (LE) and 10 mmol dm−3 glycyl-glycine as terminating (TE) electrolytes. The second method was used for indirect analysis of MT as tartrate ions. In this case, the leading electrolyte consisted of 10 mmol dm−3 HCl, β-alanine (BALA), pH 4-5, and the terminating one of 5 mmol dm−3 glutamic acid, 10 mmol dm−3 β-alanine. Calibration curves were calculated as follows: for system A: y = (0.52 ± 0.05)x − (0.9 ± 0.2) (LOD = 13.0 mg dm−3, LOQ = 31.7 mg dm−3); and for system B: y = (0.240 +- 0.001)x + (0.18 ± 0.06) (LOD = 1.8 mg dm−3, LOQ = 4.4 mg dm−3). The isotachophoretic method was compared with the pharmacopoeial one by statistical tests.

Keywords: capillary isotachophoresis; metoprolol tartrate; Metocard; Metohexal; Betaloc

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Published Online: 2010-3-31
Published in Print: 2010-6-1

© 2009 Institute of Chemistry, Slovak Academy of Sciences

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  4. Determination of metoprolol tartrate by capillary isotachophoresis
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https://doi.org/10.2478/s11696-010-0002-1
Keywords for this article
capillary isotachophoresis; metoprolol tartrate; Metocard; Metohexal; Betaloc

Articles in the same Issue

  1. A proposal of reference values for relative uncertainty increase in spectrophotometric analysis of pharmaceutical formulations
  2. Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes
  3. A simple turbidimetric flow injection system for saccharin determination in sweetener products
  4. Determination of metoprolol tartrate by capillary isotachophoresis
  5. Model predictive control of a CSTR: A hybrid modeling approach
  6. Application of extended NRTL equation for ternary liquid-liquid and vapor-liquid-liquid equilibria description
  7. Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base
  8. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 4-cyanopyridine Cu4OBrnCl(6−n)(4-CNpy)4 complexes
  9. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 3-cyanopyridine Cu4OBrnCl(6−n)(3-CNpy)4 complexes
  10. Deposition and release of chlorhexidine from non-ionic and anionic polymer matrices
  11. Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
  12. Spectroscopic characterization of halogen- and cyano-substituted pyridinevinylenes synthesized without catalyst or solvent
  13. Chemical composition and antimicrobial activity of Erodium species: E. ciconium L., E. cicutarium L., and E. absinthoides Willd. (Geraniaceae)
  14. Photo-Fenton and photo-Fenton-like processes for the degradation of methyl orange in aqueous medium: Influence of oxidation states of iron
  15. Voltammetry of resazurin at a mercury electrode
  16. Effect of dielectric medium on angiotensin converting enzyme inhibitors binding to Zn2+
  17. HPLC analysis of a syrup containing nimesulide and its hydrolytic degradation product
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