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Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes

  • Alaa Amin EMAIL logo , Ibrahim Ahmed , Hassan Dessouki and Hassan Mohamed
Published/Copyright: March 31, 2010
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Chemical Papers
From the journal Chemical Papers Volume 64 Issue 3

Abstract

Simple and rapid spectrophotometric methods have been developed for the microdetermination of fluoxetine HCl. The proposed methods are based on the formation of ion-pair complexes between fluoxetine and bromophenol blue (BPB), bromothymol blue (BTB), bromocresol green (BCG), and bromocresol purple (BCP) which can be measured at optimum λmax. Optimization of reaction conditions was investigated. Beerșs law was obeyed in the concentration ranges of 0.5–8.0 μg mL−1, whereas optimum concentration as adopted from the Ringbom plots was 0.7–7.7 μg mL−1. The molar absorptivity, Sandell sensitivity, and detection limit were also calculated. The most optimal and sensitive method was developed using BCG. The correlation coefficient was 0.9988 (n = 6) with a relative standard deviation of 1.25, for six determinations of 4.0 μg mL−1. The proposed methods were successfully applied to the determination of fluoxetine hydrochloride in its dosage forms and in biological fluids (spiked plasma sample) using the standard addition technique.

Keywords: spectrophotometry; fluoxetine hydrochloride; ion-pair complex formation; dosage forms; quality control; quality assurance

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Published Online: 2010-3-31
Published in Print: 2010-6-1

© 2009 Institute of Chemistry, Slovak Academy of Sciences

Articles in the same Issue

  1. A proposal of reference values for relative uncertainty increase in spectrophotometric analysis of pharmaceutical formulations
  2. Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes
  3. A simple turbidimetric flow injection system for saccharin determination in sweetener products
  4. Determination of metoprolol tartrate by capillary isotachophoresis
  5. Model predictive control of a CSTR: A hybrid modeling approach
  6. Application of extended NRTL equation for ternary liquid-liquid and vapor-liquid-liquid equilibria description
  7. Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base
  8. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 4-cyanopyridine Cu4OBrnCl(6−n)(4-CNpy)4 complexes
  9. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 3-cyanopyridine Cu4OBrnCl(6−n)(3-CNpy)4 complexes
  10. Deposition and release of chlorhexidine from non-ionic and anionic polymer matrices
  11. Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
  12. Spectroscopic characterization of halogen- and cyano-substituted pyridinevinylenes synthesized without catalyst or solvent
  13. Chemical composition and antimicrobial activity of Erodium species: E. ciconium L., E. cicutarium L., and E. absinthoides Willd. (Geraniaceae)
  14. Photo-Fenton and photo-Fenton-like processes for the degradation of methyl orange in aqueous medium: Influence of oxidation states of iron
  15. Voltammetry of resazurin at a mercury electrode
  16. Effect of dielectric medium on angiotensin converting enzyme inhibitors binding to Zn2+
  17. HPLC analysis of a syrup containing nimesulide and its hydrolytic degradation product
https://doi.org/10.2478/s11696-010-0010-1
Keywords for this article
spectrophotometry; fluoxetine hydrochloride; ion-pair complex formation; dosage forms; quality control; quality assurance

Articles in the same Issue

  1. A proposal of reference values for relative uncertainty increase in spectrophotometric analysis of pharmaceutical formulations
  2. Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes
  3. A simple turbidimetric flow injection system for saccharin determination in sweetener products
  4. Determination of metoprolol tartrate by capillary isotachophoresis
  5. Model predictive control of a CSTR: A hybrid modeling approach
  6. Application of extended NRTL equation for ternary liquid-liquid and vapor-liquid-liquid equilibria description
  7. Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base
  8. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 4-cyanopyridine Cu4OBrnCl(6−n)(4-CNpy)4 complexes
  9. Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 3-cyanopyridine Cu4OBrnCl(6−n)(3-CNpy)4 complexes
  10. Deposition and release of chlorhexidine from non-ionic and anionic polymer matrices
  11. Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
  12. Spectroscopic characterization of halogen- and cyano-substituted pyridinevinylenes synthesized without catalyst or solvent
  13. Chemical composition and antimicrobial activity of Erodium species: E. ciconium L., E. cicutarium L., and E. absinthoides Willd. (Geraniaceae)
  14. Photo-Fenton and photo-Fenton-like processes for the degradation of methyl orange in aqueous medium: Influence of oxidation states of iron
  15. Voltammetry of resazurin at a mercury electrode
  16. Effect of dielectric medium on angiotensin converting enzyme inhibitors binding to Zn2+
  17. HPLC analysis of a syrup containing nimesulide and its hydrolytic degradation product
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