Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
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Biljana Dekić
,
Vidoslav Dekić
Abstract
A series of new coumarin derivatives has been synthesized by condensation of 4-chloro-3-nitrocoumarin and the appropriate arylamine and sulfonamide in ethyl acetate in the presence of triethylamine. The synthesized compounds were screened for their in vitro antimicrobial activity against thirteen strains of bacteria and three fungal/yeast strains using disk diffusion assays. They were shown to possess a wide range of activities from almost completely inactive compounds to medium active ones. (4-[(5-Chloropyridin-2-yl)amino]-3-nitro-2H-chromen-2-one) showed similar activity against Klebsiella pneumoniae as tetracycline.
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© 2009 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- A proposal of reference values for relative uncertainty increase in spectrophotometric analysis of pharmaceutical formulations
- Spectrophotometric quantification of fluoxetine hydrochloride: Application to quality control and quality assurance processes
- A simple turbidimetric flow injection system for saccharin determination in sweetener products
- Determination of metoprolol tartrate by capillary isotachophoresis
- Model predictive control of a CSTR: A hybrid modeling approach
- Application of extended NRTL equation for ternary liquid-liquid and vapor-liquid-liquid equilibria description
- Synthesis, DNA binding, and antimicrobial studies of novel metal complexes containing a pyrazolone derivative Schiff base
- Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 4-cyanopyridine Cu4OBrnCl(6−n)(4-CNpy)4 complexes
- Synthesis, spectral and electrochemical study of coordination molecules Cu4OX6L4: 3-cyanopyridine Cu4OBrnCl(6−n)(3-CNpy)4 complexes
- Deposition and release of chlorhexidine from non-ionic and anionic polymer matrices
- Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins
- Spectroscopic characterization of halogen- and cyano-substituted pyridinevinylenes synthesized without catalyst or solvent
- Chemical composition and antimicrobial activity of Erodium species: E. ciconium L., E. cicutarium L., and E. absinthoides Willd. (Geraniaceae)
- Photo-Fenton and photo-Fenton-like processes for the degradation of methyl orange in aqueous medium: Influence of oxidation states of iron
- Voltammetry of resazurin at a mercury electrode
- Effect of dielectric medium on angiotensin converting enzyme inhibitors binding to Zn2+
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