Startseite Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease
Artikel Open Access

Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease

  • Paolo Laperuta , Filomena Napolitano , Rosa Maria Di Crescenzo , Pio Zeppa , Antonio Galderisi , Carmine Selleri , Alessandro Vatrella , Mario Capunzo und Vincenzo Giuseppe Di Crescenzo EMAIL logo
Veröffentlicht/Copyright: 19. November 2016
Artikel downloaden (PDF)
Open Medicine
Aus der Zeitschrift Open Medicine Band 11 Heft 1

Abstract

A 82-year-old patient with dyspnea and a recurrent history of pleural effusion was admitted into our unit. He performed a Chest computed tomography showing right pleural effusion. Video-assisted thoracoscopy (VATS) exploratory showed parietal pleural thickening of adipose tissue. The surgical procedure consisted, therefore, in the execution of multiple biopsies of the parietal pleura which appeared covered, on the whole surface, by islands of adipose tissue, without macroscopic pathological aspects. After the procedure was performed pleurodesis with talc. The definitive histological examination consisted of normal mesothelial cells surrounded by fatty tissue infiltrated by small lymphocytes in a patient without skin lesions or visceral or systemic signs of inflammatory involvement of the adipose tissue. We reported a rare case of idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease.

Keywords: Panniculitis; Thoracoscopy; Exploratory excision; Weber-Christian disease

1 Introduction

Idiopathic panniculitis is a systemic inflammatory non suppurative disease of adipose tissue of unknown aetiology [1-4]. This clinical evidence is often observed in Weber-Christian disease (WCD) associated with cutaneous lesions (recurrent subcutaneous inflammatory painful nodules) and systemic manifestations (fever, malaise and, sometimes, flogistic involvement of the lungs, heart, gastrointestinal tract, spleen, kidneys, and adrenal glands). The diagnosis of lobular panniculitis, in our case, was obtained on pleural biopsy with histological examination consisting of normal mesothelial cells surrounded by fatty tissue infiltrated by small lymphocytes without skin lesions or visceral or systemic signs [6-15]. In our case, we reported a pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease.

2 Case Report

A 82 year old man was hospitalized because of fever, dyspnea and right pleural effusion. He had an history of repeated thoracentesis, diabetes (NIDDM) and COPD. On hospital admission, clinical general conditions showed a pulse rate 80 and respiratory rate 34 per minute without hepato-splenomegaly neither painful erythematous subcutaneous nodules. A chest roentgenogram showed a right-sided pleural effusion. A subsequent total body computed tomography (CT) confirmed the pleural effusion with no evidence of pancreatic abnormality. Laboratory data showed an erythrocyte sedimentation (VES) rate of 15 mm·h-1 and C-reactive protein (CRP) of 3.0 mg·dL-1. White blood cell count was 7,500 cells·mm-3 (7.5 × 109·L-1) with Haemoglobin concentration of 130 g·L-1, and 240,000 platelets·mm-3 (240 × 109·L-1). Glutamic oxaloacetic transaminase (GOT) was 34 IU·L-1, and glutamic pyruvic transaminase (GPT) 40 IU·dL-1. Lactate dehydrogenase (LDH) was 650 IU·L-1, and creatine phosphokinase (CPK) was 350 IU·L-1. Serum amylase was 85 IU·L-1, and lipase was 30 IU-L-1. Electrophoretic protein pattern was 6.0g·dL-1, and albumin 3.0g·dL-1. No antibodies against itself were produced (tests for antinuclear factor, rheumatoid factor and immunocomplex) and urinalysis was normal. Alpha1-antitrypsin (A1AT) was 184 mg·dL-1. QuantiFeron test was negative. A cardiology evaluation showed no heart failure manifestations. Right-sided thoracentesis showed a sterile pleural exudate with pleural adenosine deaminase (ADA) level not elevated. Respiratory function showed a moderate obstructive deficit. Thoracoscopic examination revealed parietal pleural thickening of adipose tissue. The surgical procedure consisted, therefore, in the execution of multiple biopsies of the parietal pleura which appeared covered, on the whole surface, by islands of adipose tissue, without macroscopic pathological aspects (Fig. 1). After the procedure we performed pleurodesis with talc. The definitive histological examination consisted of normal mesothelial cells surrounded by fatty tissue infiltrated by small lymphocytes. The patient had no skin lesions or visceral or systemic signs of flogistic involvement of the adipose tissue. Treatment with prednisolone (50 mg·day-1 for the first week, then 25 mg for the second week) was initiated. A one month-follow up showed no pleural effusion and a complete resolution of symptoms.

Figures 1-3 Images of the parietal pleura which appeared covered, on the whole surface, by islands of adipose tissue, without macroscopic pathological aspects.
Figures 1-3

Images of the parietal pleura which appeared covered, on the whole surface, by islands of adipose tissue, without macroscopic pathological aspects.

Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

Informed consent: Informed consent has been obtained from all individuals included in this study.

3 Discussion

Weber-Christian disease (WCD) [16-24] characters (recurrent non-suppurative nodular panniculitis [25-30], fever and painful cutaneous nodules, malaise, arthralgia, hepatosplenomegaly, weight loss and anorexia [31-38]) were described by Weber first, and Christian subsequently. While lobular panniculitis associated with extensive visceral involvement may lead to a severe prognosis and eventually to death, due to sepsis, hepatic failure, hemorrhage, and thrombosis, only cutaneous involvement was a positive prognostic indicator. Pleuritis is a rare complication of this systemic panniculitis [39-44]. Deficient levels of pleural ADA were not found. The thoracic complications, in our case, were not associated with extensive visceral involvement. A diagnostic thoracoscopy, performed for recurrent pleural effusion, showed pleural thickening on the whole surface with islands of adipose tissue, without macroscopic pathological aspects.

Pleural thickening biopsy allowed us to diagnose of Idiopathic pleural panniculitis.

In our case, thoracoscopic biopsies allowed us to diagnose a rare case of idiopathic pleural panniculitis with recurrent pleural effusion and fever not associated with Weber-Christian disease.

4 Conclusions

Idiopathic pleural panniculitis is a very rare occurrence because in the literature are reported only few cases of pleural involvement secondary to idiopathic pulmonary panniculitis, as in the case of Weber-Christian disease or cases of benign pleural lipoma, in which is frequent the involvement of the mediastinum, lung, bronchus, but, rarely, however, the only involvement of the parietal pleura. The presence of pleural panniculitis form with parietal pleural thickening of adipose tissue, without pathological aspects of mesothelial cells, and the presence of lymphocytic infiltrates within the adipose tissue, in a patient with no cutaneous or visceral lesions or signs of systemic inflammatory disease of the adipose tissue, is an occurrence not reported so far in the literature.

  1. Conflict of interest: The authors declare that they have no conflict of interest or any financial support.

References

[1] Lazarus GS. Panniculitis and disorders of the subcutaneous fat. In: Wyngaarden JB, Smith LH, eds. Cecil Textbook of Medicine, 18th edn. Philadelphia, W. B. Saunders Co., 1988; 2050–2051Suche in Google Scholar

[2] Panush RS, Yonker RA, Dlesk AD, Longley S, Caldwell JR. Weber-Christian disease: analysis of 15 cases and review of the literature. Medicine 1985; 64: 181–19110.1097/00005792-198505000-00003Suche in Google Scholar

[3] Weber FP. A case of relapsing nonsuppurative panniculitis, showing phagocytosis of fat cells by macrophages. Br J Dermatol 1925; 37: 301–31110.1111/j.1365-2133.1925.tb10003.xSuche in Google Scholar

[4] Christian HA. Relapsing febrile nodule nonsuppurative panniculitis. Arch Intern Med 1928; 42: 338–35110.1001/archinte.1928.00020020026004Suche in Google Scholar

[5] Smith KC, Pittelkow MR, Su WP. Panniculitis associated with severe alpha1-antitrypsin deficiency: treatment and review of the literature. Arch Dermatol 1987; 123: 1655–166110.1001/archderm.1987.01660360083017Suche in Google Scholar

[6] Kumagai-Kurata N, Kunitoh H, Nagamine-Nishizawa M, Watanbe K, Nakamura N. Idiopathic lobular panniculitis with specific pleu-ral involvement. Eur Respir J 1995: 1613-161510.1183/09031936.95.08091613Suche in Google Scholar

[7] Pfeifer V. Über einen Fall von herdweiser Atrophie des subku-tanen Fettgewebes. Deutsches Archiv für klinische Medizin, Leipzig 1892: 438-449Suche in Google Scholar

[8] Weber FP. A case of relapsing non-suppurative nodular panniculi-tis, showing phagocytosis of subcutaneous fat-cells by macro-phages. British Journal of Dermatology and Syphilis, Oxford 1925: 301-33110.1111/j.1365-2133.1925.tb10003.xSuche in Google Scholar

[9] Christian HA. Relapsing febrile nodular nonsuppurative panniculi-tis. Arch Intern Med, Chicago 1928: 338-35110.1001/archinte.1928.00020020026004Suche in Google Scholar

[10] Hyun SH, Kang YM, Kim CD, Lee JM, Kim IT, Kim NS. Weber-Christian disease presenting with proptosis: a case report. J Ko-rean Med Sci 2000: 247-25010.3346/jkms.2000.15.2.247Suche in Google Scholar PubMed PubMed Central

[11] Di Crescenzo V, Laperuta P, Garzi A, Napolitano F, Cascone A, Vatrella A. Small cell lung cancer associated with solitary fibrous tumors of the pleura: a case study and literature review. Int J Surg. 2014; 12 Suppl 1:S19-21. doi: 10.1016/j.ijsu.2014.05.032. Epub 2014 May 22. Review. PubMed PMID: 24859397Suche in Google Scholar PubMed

[12] Baganha MF, Pego A, Lima MA, Gaspar EV, Pharm B, Cordeiro AR. Serum and pleural adenosine deaminase: correlation with lymphocytic populations. Chest 1990; 97: 605–61010.1378/chest.97.3.605Suche in Google Scholar PubMed

[13] Laperuta P, Napolitano F, Garzi A, Amato B, Vatrella A, Di Crescenzo V. Extrathoracic recurrence of type A thymoma. Int J Surg. 2014;12 Suppl 1:S16-1810.1016/j.ijsu.2014.05.043Suche in Google Scholar PubMed

[14] Di Crescenzo V, Laperuta P, Napolitano F, Carlomagno C, Danzi M, Amato B, Garzi A, Vitale M. Unusual case of exacerbation of sub-acute descending necrotizing mediastinitis. BMC Surg. 2013;13 Suppl 2:S31. doi: 10.1186/1471-2482-13-S2-S31. Epub 2013 Oct 8Suche in Google Scholar PubMed PubMed Central

[15] Caleo A, Vigliar E, Vitale M, Di Crescenzo V, Cinelli M, Carlomagno C, Garzi A, Zeppa P. Cytological diagnosis of thyroid nodules in Hashimoto thyroiditis in elderly patients. BMC Surg. 2013;13 Suppl 2:S4110.1186/1471-2482-13-S2-S41Suche in Google Scholar PubMed PubMed Central

[16] Guerra A, Carrano M, Angrisani E, Puzziello A, Izzo G, Di Crescenzo V, Vatrella A, Vitale M. Detection of RAS mutation by pyrosequencing in thyroid cytology samples. Int J Surg. 2014; 12 Suppl 1:91-9410.1016/j.ijsu.2014.05.045Suche in Google Scholar PubMed

[17] Peluso AL, Cascone AM, Lucchese L, Cozzolino I, Ieni A, Mignogna C, Pepe S, Zeppa P. Use of FTA cards for the storage of breast carcinoma nucleic acid on fine-needle aspiration samples. Cancer Cytopathol. 2015; 123(10):582-92. doi: 10.1002/cncy.21577. Epub 2015 Jun 29Suche in Google Scholar PubMed

[18] Guerra A, Di Crescenzo V, Garzi A, Cinelli M, Carlomagno C, Pepe S, Zeppa P, Tonacchera M, Vitale M. Diagnostic utility of BRAFV600E mutation testing in thyroid nodules in elderly patients. BMC Surg. 2013;13 Suppl 2:S37. doi: 10.1186/1471-2482-13-S2-S37. Epub 2013 Oct 8Suche in Google Scholar PubMed PubMed Central

[19] Olivieri A, Cimminiello M, Corradini P, Mordini N, Fedele R, Selleri C, Onida F, Patriarca F, Pavone E, Svegliati S, Gabrielli A, Bresciani P, Nuccorini R, Pascale S, Coluzzi S, Pane F, Poloni A, Olivieri J, Leoni P, Bacigalupo A. Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD. Blood. 2013 Dec 12;122(25):4111-411810.1182/blood-2013-05-494278Suche in Google Scholar PubMed

[20] Guerra A, Di Crescenzo V, Garzi A, Cinelli M, Carlomagno C, Tonacchera M, Zeppa P, Vitale M. Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review. BMC Surg. 2013;13 Suppl 2:S44. doi: 10.1186/1471-2482-13-S2-S44. Epub 2013 Oct 8. ReviewSuche in Google Scholar PubMed PubMed Central

[21] Cozzolino I, Varone V, Picardi M, Baldi C, Memoli D, Ciancia G, Selleri C, De Rosa G, Vetrani A, Zeppa P. CD10, BCL6, and MUM1 expression in diffuse large B-cell lymphoma on FNA samples. Cancer Cytopathol. 2016 Feb;124(2):135–143. doi: 10.1002/cncy.21626. Epub 2015 Sep 28Suche in Google Scholar PubMed

[22] Laperuta P, Napolitano F, Vatrella A, Di Crescenzo RM, Cortese A, Di Crescenzo V. Post-pneumonectomy bronchopleural fistula successfully closed by open-window thoracostomy associated with V. A. C. therapy. Int J Surg. 2014;12 Suppl 2:S17-9. doi: 10.1016/j.ijsu.2014.08.390. Epub 2014 Aug 23. PubMed PMID: 25159544Suche in Google Scholar PubMed

[23] Selleri C, Maciejewski JP, Montuori N, Ricci P, Visconte V, Serio B, Luciano L, Rotoli B. Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cells. Blood. 2003 Aug 15;102(4):1490-149810.1182/blood-2003-01-0178Suche in Google Scholar PubMed

[24] Cozzolino I, Vigliar E, Todaro P, Peluso AL, Picardi M, Sosa Fernandez LV, Mignogna MD, Tuccari G, Selleri C, Zeppa P. Fine needle aspiration cytology of lymphoproliferative lesions of the oral cavity. Cytopathology. 2014 Aug; 25 (4): 241-249. doi: 10.1111/cyt.12132. Epub 2014 Feb 7Suche in Google Scholar PubMed

[25] Baldi A, Mottolese M, Vincenzi B, Campioni M, Mellone P, Di Marino M, di Crescenzo VG, Visca P, Menegozzo S, Spugnini EP, Citro G, Ceribelli A, Mirri A, Chien J, Shridhar V, Ehrmann M, Santini M, Facciolo F. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics. 2008 Aug;9(8):1069–107710.2217/14622416.9.8.1069Suche in Google Scholar PubMed

[26] Cozzolino I, Vigliar E, Sosa Fernandez LV, Selleri C, Pepe S, Vitale M, Triggiani M, Zeppa P. Non lymphomatous clonal B-Cell populations in enlarged lymph nodes in acquired immunodeficiency syndrome. Infez Med. 2012;20 Suppl 2:35–42Suche in Google Scholar

[27] Santini M, Fiorelli A, Messina G, Laperuta P, Mazzella A, Accardo M. Use of the LigaSure device and the Stapler for closure of the small bowel: a comparative ex vivo study. Surg Today. 2013 Jul;43(7):787–793. doi: 10.1007/s00595-012-0336-0. Epub 2012 Sep 15.Suche in Google Scholar PubMed

[28] Zeppa P, Barra E, Napolitano V, Cozzolino I, Troncone G, Picardi M, De Renzo A, Mainenti PP, Vetrani A, Palombini L. Impact of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in lymph nodal and mediastinal lesions: a multicenter experience. Diagn Cytopathol. 2011 Oct;39(10):723–729. doi: 10.1002/dc.21450. Epub 2010 Oct 19Suche in Google Scholar PubMed

[29] Tauchmanovà L, Selleri C, De Rosa G, Esposito M, Di Somma C, Orio F, Palomba S, Lombardi G, Rotoli B, Colao A. Endocrine disorders during the first year after autologous stem-cell transplant Am J Med. 2005 Jun;118(6):664–67010.1016/j.amjmed.2005.02.009Suche in Google Scholar PubMed

[30] Santini M, Fiorello A, Vicidomini G, Di Crescenzo VG, Laperuta P. Role of diffusing capacity in predicting complications after lung resection for cancer. Thorac Cardiovasc Surg. 2007 Sep;55(6):391–39410.1055/s-2007-965326Suche in Google Scholar PubMed

[31] Vigliar E, Cozzolino I, Picardi M, Peluso AL, Fernandez LV, Vetrani A, Botti G, Pane F, Selleri C, Zeppa P. Lymph node fine needle cytology in the staging and follow-up of cutaneous lymphomas. BMC Cancer. 2014 Jan 6;14:8. doi: 10.1186/1471-2407-14-8Suche in Google Scholar PubMed PubMed Central

[32] Tauchmanovà L, Selleri C, De Rosa G, Esposito M, Orio F Jr, Palomba S, Bifulco G, Nappi C, Lombardi G, Rotoli B, Colao A. Gonadal status in reproductive age women after haematopoietic stem cell transplantation for haematological malignancies. Hum Reprod. 2003 Jul;18(7):1410–141610.1093/humrep/deg295Suche in Google Scholar PubMed

[33] Di Crescenzo V., Laperuta P., Napolitano F., Carlomagno C., Garzi A., Vitale M. Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. BMC SURGERY (2013). Pag.1-3 ISSN:1471–248210.1186/1471-2482-13-S2-S34Suche in Google Scholar PubMed PubMed Central

[34] Caleo A, Vigliar E, Vitale M, Di Crescenzo V, Cinelli M, Carlomagno C, Garzi A, Zeppa P. Cytological diagnosis of thyroid nodules in Hashimoto thyroiditis in elderly patients. BMC Surg. 2013;13 Suppl 2:S41. doi: 10.1186/1471-2482-13-S2-S41. Epub 2013 Oct 8Suche in Google Scholar PubMed PubMed Central

[35] Fiorelli A, Morgillo F, Fasano M, Vicidomini G, Di crescenzo V. G, Di Domenico M, Accardo M, Santini M. The value of matrix metalloproteinase 9 and vascular endothelial growth factor receptor 1 pathway in diagnosing indeterminate pleural. INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY (2012). Pag. 1-7 ISSN:1569–929310.1093/icvts/ivs466Suche in Google Scholar PubMed PubMed Central

[36] Zeppa P, Sosa Fernandez LV, Cozzolino I, Ronga V, Genesio R, Salatiello M, Picardi M, Malapelle U, Troncone G, Vigliar E. Immunoglobulin heavy-chain fluorescence in situ hybridization-chromogenic in situ hybridization DNA probe split signal in the clonality assessment of lymphoproliferative processes on cytological samples. Cancer Cytopathol. 2012 Dec 25;120(6):390-400. doi: 10.1002/cncy.21203. Epub 2012 Apr 19Suche in Google Scholar PubMed

[37] Di Crescenzo V., Laperuta P., Napolitano F., Carlomagno C., Garzi A., Vitale M. An unusual case of primary choriocarcinoma of the lung. BMC SURGERY (2013). Pag. 1-3 ISSN:1471–248210.1186/1471-2482-13-S2-S33Suche in Google Scholar

[38] Santini M, Fiorello A, Di Crescenzo VG, Vicidomini G, Busiello L, Laperuta P. Use of unidirectional endobronchial valves for the treatment of giant emphysematous bulla. J Thorac Cardiovasc Surg. 2010 Jan;139(1):224–226. doi: 10.1016/j.jtcvs.2008.05.069. Epub 2009 Feb 4Suche in Google Scholar PubMed

[39] Fiorelli A., S. Mazzone, V. G. Di Crescenzo, G. Vicidomini, S. Costanza, A. Del Prete, A. Mazzone, M. Santini. A simple technique to facilitate dumon silicone stent placement in subglottic tracheal stenosis. Interact Cardiovasc Thorac Surg. 2014 Mar;18(3):390–392. doi: 10.1093/icvts/ivt504. Epub 2013 Dec 9Suche in Google Scholar PubMed PubMed Central

[40] Santini M, Fiorelli A, Vicidomini G, Laperuta P, Di Crescenzo VG. Iatrogenic air leak successfully treated by bronchoscopic placement of unidirectional endobronchial valves. Ann Thorac Surg. 2010 Jun;89(6):2007–2010. doi: 10.1016/j.athoracsur.2009.10.015Suche in Google Scholar PubMed

[41] Di Crescenzo V, Vitale M, Valvano L, Napolitano F, Vatrella A, Zeppa P, De Rosa G, Amato B, Laperuta P. Surgical management of cervico-mediastinal goiters: Our experience and review of the literature. Int J Surg. 2016 Apr;28 Suppl 1:S47–53. doi: 10.1016/j.ijsu.2015.12.048. Epub 2015 Dec 23Suche in Google Scholar PubMed

[42] Di Crescenzo V., Laperuta P., Napolitano F., Carlomagno, Danzi M., Amato B., Garzi A., Vitale M. Migration of surgical clips through a right lobectomy stump mimicking an asthmatic syndrome. BMC SURGERY (2013) Pag. 1-3 ISSN:1471–248210.1186/1471-2482-13-S2-S32Suche in Google Scholar PubMed PubMed Central

[43] Santini M, Fiorello A, Di Lieto E, Di Crescenzo VG, D’aniello G, Vicidomini G, Perrone A, Pastore V. Surgicalstrategies in cervico-mediastinalgoiters. . MINERVA CHIRURGICA, vol. 61, 2006 p. 221-229, ISSN: 0026-4733Suche in Google Scholar

[44] Rigacci L, Puccini B, Dodero A, Iacopino P, Castagna L, Bramanti S, Ciceri F, Fanin R, Rambaldi A, Falda M, Milone G, Guidi S, Martelli MF, Mazza P, Oneto R, Bosi A, Foà R, Leoni P, Liso V, Pioltelli P, Cascavilla N, Scimé R, Rizzoli V, Ballestrero A, Raimondi R, Arcese W, Musso M, Benedetti F, Guerrasio A, Majolino I, Lambertenghi DG, Baccarani M, Bacigalupo A, Petrini M, Carella AM, Levis A, La Nasa G, Merli F, Narni F, Lauria F, Cortelazzo S, Longinotti M, Olivieri A, Favre C, Cantore N, Da Prada GA, Selleri C, Bruno B, Giovanni M, Leone G, Di Bartolomeo P, Morandi S, Vallisa D. Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: a GITMO study. Ann Hematol. 2012 Jun;91(6):931–93910.1007/s00277-011-1395-9Suche in Google Scholar PubMed

Received: 2016-9-16
Accepted: 2016-9-19
Published Online: 2016-11-19
Published in Print: 2016-1-1

© 2016 Paolo Laperuta et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Artikel in diesem Heft

  1. Research Article
  2. The possible molecular regulation mechanism of CIK cells inhibiting the proliferation of Human Lung Adenocarcinoma NCL-H157 Cells
  3. Case Report
  4. Urethral stone of unexpected size: case report and short literature review
  5. Case Report
  6. Complete remission through icotinib treatment in Non-small cell lung cancer epidermal growth factor receptor mutation patient with brain metastasis: A case report
  7. Research Article
  8. FPL tendon thickness, tremor and hand functions in Parkinson’s disease
  9. Research Article
  10. Diagnostic value of circulating tumor cells in cerebrospinal fluid
  11. Research Article
  12. A meta-analysis of neuroprotective effect for traditional Chinese medicine (TCM) in the treatment of glaucoma
  13. Research Article
  14. MiR-218 increases sensitivity to cisplatin in esophageal cancer cells via targeting survivin expression
  15. Research Article
  16. Association of HOTAIR expression with PI3K/Akt pathway activation in adenocarcinoma of esophagogastric junction
  17. Research Article
  18. The role of interleukin genes in the course of depression
  19. Case Report
  20. A rare case of primary pulmonary diffuse large B cell lymphoma with CD5 positive expression
  21. Research Article
  22. DWI and SPARCC scoring assess curative effect of early ankylosing spondylitis
  23. Research Article
  24. The diagnostic value of serum CEA, NSE and MMP-9 for on-small cell lung cancer
  25. Case Report
  26. Dysphonia – the single symptom of rifampicin resistant laryngeal tuberculosis
  27. Review Article
  28. Development of epidermal growth factor receptor tyrosine kinase inhibitors against EGFR T790M. Mutation in non small-cell lung carcinoma
  29. Research Article
  30. Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer
  31. Research Article
  32. Expression analysis of the TGF-β/SMAD target genes in adenocarcinoma of esophagogastric junction
  33. Research Article
  34. Blood cells in thyroid cancer patients: a possible influence of apoptosis
  35. Research Article
  36. Detected EGFR mutation in cerebrospinal fluid of lung adenocarcinoma patients with meningeal metastasis
  37. Mini-review
  38. Pathogenesis-oriented approaches for the management of corticosteroid-resistant or relapsedprimary immune thrombocytopenia
  39. Research Article
  40. GSTP1 A>G polymorphism and chemosensitivity of osteosarcoma: A meta-analysis
  41. Research Article
  42. A meta-analysis of adiponectin gene rs22411766 T>G polymorphism and ischemic stroke susceptibility
  43. Research Article
  44. The diagnosis and pathological value of combined detection of HE4 and CA125 for patients with ovarian cancer
  45. Research Article
  46. SOX7 inhibits tumor progression of glioblastoma and is regulated by miRNA-24
  47. Research Article
  48. Sevoflurane affects evoked electromyography monitoring in cerebral palsy
  49. Case Report
  50. A case report of hereditary spherocytosis with concomitant chronic myelocytic leukemia
  51. Case Report
  52. A case of giant saphenous vein graft aneurysm followed serially after coronary artery bypass surgery
  53. Research Article
  54. LncRNA TUG1 is upregulated and promotes cell proliferation in osteosarcoma
  55. Review Article
  56. Meningioma recurrence
  57. Case Report
  58. Endobronchial amyloidosis mimicking bronchial asthma: a case report and review of the literature
  59. Case Report
  60. A confusing case report of pulmonary langerhans cell histiocytosis and literature review
  61. Research Article
  62. Effect of hesperetin on chaperone activity in selenite-induced cataract
  63. Research Article
  64. Clinical value of self-assessment risk of osteoporosis in Chinese
  65. Research Article
  66. Correlation analysis of VHL and Jade-1 gene expression in human renal cell carcinoma
  67. Research Article
  68. Is acute appendicitis still misdiagnosed?
  69. Retraction
  70. Retraction of: application of food-specific IgG antibody detection in allergy dermatosis
  71. Review Article
  72. Platelet Rich Plasma: a short overview of certain bioactive components
  73. Research Article
  74. Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis
  75. Review Article
  76. Standards of anesthesiology practice during neuroradiological interventions
  77. Research Article
  78. Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia
  79. Letter to the Editor
  80. ARDS diagnosed by SpO2/FiO2 ratio compared with PaO2/FiO2 ratio: the role as a diagnostic tool for early enrolment into clinical trials
  81. Research Article
  82. Impact of sensory integration training on balance among stroke patients: sensory integration training on balance among stroke patients
  83. Review Article
  84. MicroRNAs as regulatory elements in psoriasis
  85. Review Article
  86. Influenza A(H1N1)pdm09 and postpandemic influenza in Lithuania
  87. Review Article
  88. Garengeot’s hernia: two case reports with CT diagnosis and literature review
  89. Research Article
  90. Concept of experimental preparation for treating dentin hypersensitivity
  91. Research Article
  92. Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy
  93. Research Article
  94. Xanthogranuloma of the sellar region diagnosed by frozen section
  95. Case Report
  96. Laparoscopic antegrade cholecystectomy: a standard procedure?
  97. Case Report
  98. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study
  99. Regular Article
  100. Sialoendoscopy, sialography, and ultrasound: a comparison of diagnostic methods
  101. Research Article
  102. Antibody Response to Live Attenuated Vaccines in Adults in Japan
  103. Conference article
  104. Excellence and safety in surgery require excellent and safe tutoring
  105. Conference article
  106. Suggestions on how to make suboptimal kidney transplantation an ethically viable option
  107. Regular Article
  108. Ectopic pregnancy treatment by combination therapy
  109. Conference article
  110. Use of a simplified consent form to facilitate patient understanding of informed consent for laparoscopic cholecystectomy
  111. Regular Article
  112. Cusum analysis for learning curve of videothoracoscopic lobectomy
  113. Regular Article
  114. A meta-analysis of association between glutathione S-transferase M1 gene polymorphism and Parkinson’s disease susceptibility
  115. Conference article
  116. Plastination: ethical and medico-legal considerations
  117. Regular Article
  118. Investigation and control of a suspected nosocomial outbreak of pan-drug resistant Acinetobacter baumannii in an intensive care unit
  119. Regular Article
  120. Multifactorial analysis of fatigue scale among nurses in Poland
  121. Regular Article
  122. Smoking cessation for free: outcomes of a study of three Romanian clinics
  123. Regular Article
  124. Clinical efficacy and safety of tripterygium glycosides in treatment of stage IV diabetic nephropathy: A meta-analysis
  125. Special Issue on Italian Society for the Study of Vascular Anomalies
  126. Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature
  127. Special Issue on Italian Society for the Study of Vascular Anomalies
  128. Surgical treatment of recidivist lymphedema
  129. Special Issue on Italian Society for the Study of Vascular Anomalies
  130. CT and MR imaging of the thoracic aorta
  131. Special Issue on Italian Society for the Study of Vascular Anomalies
  132. Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma
  133. Special Issue on Italian Society for the Study of Vascular Anomalies
  134. Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome
  135. Special Issue on Italian Society for the Study of Vascular Anomalies
  136. Prenatal diagnosis, 3-D virtual rendering and lung sparing surgery by ligasure device in a baby with “CCAM and intralobar pulmonary sequestration”
  137. Special Issue on Italian Society for the Study of Vascular Anomalies
  138. Serum levels of inhibin B in adolescents after varicocelelectomy: A long term follow up
  139. Special Issue on Italian Society for the Study of Vascular Anomalies
  140. Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature
  141. Special Issue on Italian Society for the Study of Vascular Anomalies
  142. Delayed recurrent nerve paralysis following post-traumatic aortic pseudoaneurysm
  143. Special Issue on Italian Society for the Study of Vascular Anomalies
  144. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature
  145. Special Issue on Italian Society for the Study of Vascular Anomalies
  146. Celiac axis compression syndrome: laparoscopic approach in a strange case of chronic abdominal pain in 71 years old man
  147. Special Issue on Italian Society for the Study of Vascular Anomalies
  148. A rare case of persistent hypoglossal artery associated with contralateral proximal subclavian stenosis
  149. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  150. Contralateral risk reducing mastectomy in Non-BRCA-Mutated patients
  151. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  152. Professional dental and oral surgery liability in Italy: a comparative analysis of the insurance products offered to health workers
  153. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  154. Informed consent in robotic surgery: quality of information and patient perception
  155. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  156. Malfunctions of robotic system in surgery: role and responsibility of surgeon in legal point of view
  157. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  158. Medicolegal implications of surgical errors and complications in neck surgery: A review based on the Italian current legislation
  159. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  160. Iatrogenic splenic injury: review of the literature and medico-legal issues
  161. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  162. Donation of the body for scientific purposes in Italy: ethical and medico-legal considerations
  163. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  164. Cosmetic surgery: medicolegal considerations
  165. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  166. Voluntary termination of pregnancy (medical or surgical abortion): forensic medicine issues
  167. Review Article
  168. Role of Laparoscopic Splenectomy in Elderly Immune Thrombocytopenia
  169. Review Article
  170. Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system
  171. Review Article
  172. Efficacy and safety of splenectomy in adult autoimmune hemolytic anemia
  173. Research Article
  174. Relationship between gastroesophageal reflux disease and Ph nose and salivary: proposal of a simple method outpatient in patients adults
  175. Case Report
  176. Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease
  177. Research Article
  178. Morbid Obesity: treatment with Bioenterics Intragastric Balloon (BIB), psychological and nursing care: our experience
  179. Research Article
  180. Learning curve for endorectal ultrasound in young and elderly: lights and shades
  181. Case Report
  182. Uncommon primary hydatid cyst occupying the adrenal gland space, treated with laparoscopic surgical approach in an old patient
  183. Research Article
  184. Distraction techniques for face and smile aesthetic preventing ageing decay
  185. Research Article
  186. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC
  187. Review Article
  188. Descending necrotizing mediastinitis in the elderly patients
  189. Research Article
  190. Prophylactic GSV surgery in elderly candidates for hip or knee arthroplasty
  191. Research Article
  192. Diagnostic yield and safety of C-TBNA in elderly patients with lung cancer
  193. Research Article
  194. The learning curve of laparoscopic holecystectomy in general surgery resident training: old age of the patient may be a risk factor?
  195. Research Article
  196. Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients
  197. Research Article
  198. Anal sphincter dysfunction in multiple sclerosis: an observation manometric study
https://doi.org/10.1515/med-2016-0071
Schlagwörter für diesen Artikel
Panniculitis; Thoracoscopy; Exploratory excision; Weber-Christian disease
Creative Commons
BY-NC-ND 3.0

Artikel in diesem Heft

  1. Research Article
  2. The possible molecular regulation mechanism of CIK cells inhibiting the proliferation of Human Lung Adenocarcinoma NCL-H157 Cells
  3. Case Report
  4. Urethral stone of unexpected size: case report and short literature review
  5. Case Report
  6. Complete remission through icotinib treatment in Non-small cell lung cancer epidermal growth factor receptor mutation patient with brain metastasis: A case report
  7. Research Article
  8. FPL tendon thickness, tremor and hand functions in Parkinson’s disease
  9. Research Article
  10. Diagnostic value of circulating tumor cells in cerebrospinal fluid
  11. Research Article
  12. A meta-analysis of neuroprotective effect for traditional Chinese medicine (TCM) in the treatment of glaucoma
  13. Research Article
  14. MiR-218 increases sensitivity to cisplatin in esophageal cancer cells via targeting survivin expression
  15. Research Article
  16. Association of HOTAIR expression with PI3K/Akt pathway activation in adenocarcinoma of esophagogastric junction
  17. Research Article
  18. The role of interleukin genes in the course of depression
  19. Case Report
  20. A rare case of primary pulmonary diffuse large B cell lymphoma with CD5 positive expression
  21. Research Article
  22. DWI and SPARCC scoring assess curative effect of early ankylosing spondylitis
  23. Research Article
  24. The diagnostic value of serum CEA, NSE and MMP-9 for on-small cell lung cancer
  25. Case Report
  26. Dysphonia – the single symptom of rifampicin resistant laryngeal tuberculosis
  27. Review Article
  28. Development of epidermal growth factor receptor tyrosine kinase inhibitors against EGFR T790M. Mutation in non small-cell lung carcinoma
  29. Research Article
  30. Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer
  31. Research Article
  32. Expression analysis of the TGF-β/SMAD target genes in adenocarcinoma of esophagogastric junction
  33. Research Article
  34. Blood cells in thyroid cancer patients: a possible influence of apoptosis
  35. Research Article
  36. Detected EGFR mutation in cerebrospinal fluid of lung adenocarcinoma patients with meningeal metastasis
  37. Mini-review
  38. Pathogenesis-oriented approaches for the management of corticosteroid-resistant or relapsedprimary immune thrombocytopenia
  39. Research Article
  40. GSTP1 A>G polymorphism and chemosensitivity of osteosarcoma: A meta-analysis
  41. Research Article
  42. A meta-analysis of adiponectin gene rs22411766 T>G polymorphism and ischemic stroke susceptibility
  43. Research Article
  44. The diagnosis and pathological value of combined detection of HE4 and CA125 for patients with ovarian cancer
  45. Research Article
  46. SOX7 inhibits tumor progression of glioblastoma and is regulated by miRNA-24
  47. Research Article
  48. Sevoflurane affects evoked electromyography monitoring in cerebral palsy
  49. Case Report
  50. A case report of hereditary spherocytosis with concomitant chronic myelocytic leukemia
  51. Case Report
  52. A case of giant saphenous vein graft aneurysm followed serially after coronary artery bypass surgery
  53. Research Article
  54. LncRNA TUG1 is upregulated and promotes cell proliferation in osteosarcoma
  55. Review Article
  56. Meningioma recurrence
  57. Case Report
  58. Endobronchial amyloidosis mimicking bronchial asthma: a case report and review of the literature
  59. Case Report
  60. A confusing case report of pulmonary langerhans cell histiocytosis and literature review
  61. Research Article
  62. Effect of hesperetin on chaperone activity in selenite-induced cataract
  63. Research Article
  64. Clinical value of self-assessment risk of osteoporosis in Chinese
  65. Research Article
  66. Correlation analysis of VHL and Jade-1 gene expression in human renal cell carcinoma
  67. Research Article
  68. Is acute appendicitis still misdiagnosed?
  69. Retraction
  70. Retraction of: application of food-specific IgG antibody detection in allergy dermatosis
  71. Review Article
  72. Platelet Rich Plasma: a short overview of certain bioactive components
  73. Research Article
  74. Correlation between CTLA-4 gene rs221775A>G single nucleotide polymorphism and multiple sclerosis susceptibility. A meta-analysis
  75. Review Article
  76. Standards of anesthesiology practice during neuroradiological interventions
  77. Research Article
  78. Expression and clinical significance of LXRα and SREBP-1c in placentas of preeclampsia
  79. Letter to the Editor
  80. ARDS diagnosed by SpO2/FiO2 ratio compared with PaO2/FiO2 ratio: the role as a diagnostic tool for early enrolment into clinical trials
  81. Research Article
  82. Impact of sensory integration training on balance among stroke patients: sensory integration training on balance among stroke patients
  83. Review Article
  84. MicroRNAs as regulatory elements in psoriasis
  85. Review Article
  86. Influenza A(H1N1)pdm09 and postpandemic influenza in Lithuania
  87. Review Article
  88. Garengeot’s hernia: two case reports with CT diagnosis and literature review
  89. Research Article
  90. Concept of experimental preparation for treating dentin hypersensitivity
  91. Research Article
  92. Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy
  93. Research Article
  94. Xanthogranuloma of the sellar region diagnosed by frozen section
  95. Case Report
  96. Laparoscopic antegrade cholecystectomy: a standard procedure?
  97. Case Report
  98. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study
  99. Regular Article
  100. Sialoendoscopy, sialography, and ultrasound: a comparison of diagnostic methods
  101. Research Article
  102. Antibody Response to Live Attenuated Vaccines in Adults in Japan
  103. Conference article
  104. Excellence and safety in surgery require excellent and safe tutoring
  105. Conference article
  106. Suggestions on how to make suboptimal kidney transplantation an ethically viable option
  107. Regular Article
  108. Ectopic pregnancy treatment by combination therapy
  109. Conference article
  110. Use of a simplified consent form to facilitate patient understanding of informed consent for laparoscopic cholecystectomy
  111. Regular Article
  112. Cusum analysis for learning curve of videothoracoscopic lobectomy
  113. Regular Article
  114. A meta-analysis of association between glutathione S-transferase M1 gene polymorphism and Parkinson’s disease susceptibility
  115. Conference article
  116. Plastination: ethical and medico-legal considerations
  117. Regular Article
  118. Investigation and control of a suspected nosocomial outbreak of pan-drug resistant Acinetobacter baumannii in an intensive care unit
  119. Regular Article
  120. Multifactorial analysis of fatigue scale among nurses in Poland
  121. Regular Article
  122. Smoking cessation for free: outcomes of a study of three Romanian clinics
  123. Regular Article
  124. Clinical efficacy and safety of tripterygium glycosides in treatment of stage IV diabetic nephropathy: A meta-analysis
  125. Special Issue on Italian Society for the Study of Vascular Anomalies
  126. Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature
  127. Special Issue on Italian Society for the Study of Vascular Anomalies
  128. Surgical treatment of recidivist lymphedema
  129. Special Issue on Italian Society for the Study of Vascular Anomalies
  130. CT and MR imaging of the thoracic aorta
  131. Special Issue on Italian Society for the Study of Vascular Anomalies
  132. Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma
  133. Special Issue on Italian Society for the Study of Vascular Anomalies
  134. Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome
  135. Special Issue on Italian Society for the Study of Vascular Anomalies
  136. Prenatal diagnosis, 3-D virtual rendering and lung sparing surgery by ligasure device in a baby with “CCAM and intralobar pulmonary sequestration”
  137. Special Issue on Italian Society for the Study of Vascular Anomalies
  138. Serum levels of inhibin B in adolescents after varicocelelectomy: A long term follow up
  139. Special Issue on Italian Society for the Study of Vascular Anomalies
  140. Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature
  141. Special Issue on Italian Society for the Study of Vascular Anomalies
  142. Delayed recurrent nerve paralysis following post-traumatic aortic pseudoaneurysm
  143. Special Issue on Italian Society for the Study of Vascular Anomalies
  144. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature
  145. Special Issue on Italian Society for the Study of Vascular Anomalies
  146. Celiac axis compression syndrome: laparoscopic approach in a strange case of chronic abdominal pain in 71 years old man
  147. Special Issue on Italian Society for the Study of Vascular Anomalies
  148. A rare case of persistent hypoglossal artery associated with contralateral proximal subclavian stenosis
  149. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  150. Contralateral risk reducing mastectomy in Non-BRCA-Mutated patients
  151. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  152. Professional dental and oral surgery liability in Italy: a comparative analysis of the insurance products offered to health workers
  153. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  154. Informed consent in robotic surgery: quality of information and patient perception
  155. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  156. Malfunctions of robotic system in surgery: role and responsibility of surgeon in legal point of view
  157. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  158. Medicolegal implications of surgical errors and complications in neck surgery: A review based on the Italian current legislation
  159. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  160. Iatrogenic splenic injury: review of the literature and medico-legal issues
  161. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  162. Donation of the body for scientific purposes in Italy: ethical and medico-legal considerations
  163. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  164. Cosmetic surgery: medicolegal considerations
  165. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  166. Voluntary termination of pregnancy (medical or surgical abortion): forensic medicine issues
  167. Review Article
  168. Role of Laparoscopic Splenectomy in Elderly Immune Thrombocytopenia
  169. Review Article
  170. Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system
  171. Review Article
  172. Efficacy and safety of splenectomy in adult autoimmune hemolytic anemia
  173. Research Article
  174. Relationship between gastroesophageal reflux disease and Ph nose and salivary: proposal of a simple method outpatient in patients adults
  175. Case Report
  176. Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease
  177. Research Article
  178. Morbid Obesity: treatment with Bioenterics Intragastric Balloon (BIB), psychological and nursing care: our experience
  179. Research Article
  180. Learning curve for endorectal ultrasound in young and elderly: lights and shades
  181. Case Report
  182. Uncommon primary hydatid cyst occupying the adrenal gland space, treated with laparoscopic surgical approach in an old patient
  183. Research Article
  184. Distraction techniques for face and smile aesthetic preventing ageing decay
  185. Research Article
  186. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC
  187. Review Article
  188. Descending necrotizing mediastinitis in the elderly patients
  189. Research Article
  190. Prophylactic GSV surgery in elderly candidates for hip or knee arthroplasty
  191. Research Article
  192. Diagnostic yield and safety of C-TBNA in elderly patients with lung cancer
  193. Research Article
  194. The learning curve of laparoscopic holecystectomy in general surgery resident training: old age of the patient may be a risk factor?
  195. Research Article
  196. Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients
  197. Research Article
  198. Anal sphincter dysfunction in multiple sclerosis: an observation manometric study
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 31.10.2025 von https://www.degruyterbrill.com/document/doi/10.1515/med-2016-0071/html?lang=de
Button zum nach oben scrollen