Startseite Delayed recurrent nerve paralysis following post-traumatic aortic pseudoaneurysm
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Delayed recurrent nerve paralysis following post-traumatic aortic pseudoaneurysm

  • Massimo Mesolella EMAIL logo , Filippo Ricciardiello , Domenico Tafuri , Roberto Varriale und Domenico Testa
Veröffentlicht/Copyright: 23. Juni 2016
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Aus der Zeitschrift Open Medicine Band 11 Heft 1

Abstract

Blunt trauma to the neck or to the chest are increasingly observed in the emergency clinical practice. They usually follow motor vehicle accidents or may be work or sports related. A wide pattern of clinical presentation can be potentially encountered. We report the uncommon case of a patient who was referred to our observation presenting with hoarseness and disphagia. Twenty days before he had sustained a car accident with trauma to the chest, neck and the mandible. Laryngoscopy showed a left recurrent laryngeal nerve palsy. Further otolaryngo-logical examination showed no other abnormality. At CT and MR imaging a post-traumatic aortic pseudoaneurysm was revealed. The aortic pseudoaneurysm was consequently repaired by implantation of an endovascular stent graft under local anesthesia. The patient was discharged 10 days later. At 30-days follow-up laryngoscopy the left vocal cord palsy was completely resolved.

Hoarseness associated with a dilated left atrium in a patient with mitral valve stenosis was initially described by Ortner more than a century ago. Since then several non malignant, cardiovascular, intrathoracic disease that results in embarrassment from recurrent laryngeal nerve palsy usually by stretching, pulling or compression; thus, the correlations of these pathologies was termed as cardiovocal syndrome or Ortner’s syndrome. The reported case illustrates that life-threatening cardiovascular comorbidities can cause hoarseness and that an impaired recurrent laryngeal nerve might be correctable.

Keywords: Recurrent nerve paralysis; aortic pseudoaneurysm; Ortner’s syndrome; cardiovocal syndrome

1 Introduction

Vocal cord paralysis is a common disease in the practice of otolaryngology. Many disease entities in the head, neck and thorax regions can cause recurrent laryngeal nerve paralysis, including ectopic dislocations, inflammatory, neoplastic, cerebrovascular, heart, degenerative and other conditions such as trauma [1-3]. Blunt trauma to the neck or to the chest are increasingly observed in the emergency clinical pratice. They usually follow motor vehicle accidents, or may be a consequence of job or sport practice. A wide pattern of clinical presentation can be potentially encountered.

The recurrent paralysis of vocal cords is not only a disease entity but may also be a symptom of other disorders (central or peripheric pathologies, non-surgical or surgical paralysis etc). Patient with unilateral recurrent laryngeal nerve paralysis complain of hoarseness and occasional liquid aspiration. Ortner described hoarseness of voice to the left recurrent laryngeal nerve palsy in three patients with severe mitral stenosis [4]. Although it was initially associated with mitral stenosis, several other case reports suggested that hoarseness can be caused and associated by numerous cardiovascular pathologies [5,6]. In particular, these can be congenital conditions (atrial and ventricular septal defect, aortopulmonary window, double outlet right ventricle) [7-9], adult disorders (left atrial enlargement, left ventricular aneurysm, thrombosed giant left atrium [10], atrial myxoma [11], aortic aneu-rysms [12-14] or pseudoaneurysms [15]), iatrogenic lesions (cardiac surgery [16,17], thoracic surgery [18], atrial fibrillation ablation procedure [19]). The termed “cardiovocal syndrome” was used in this cases [6,19].

We report the uncommon case of a patient who had undergone a chest and neck blunt trauma: after twenty days he presented with hoarseness and dysphonia. The left recurrent laryngeal nerve palsy secondary to a post-traumatic aortic pseudoaneurysm was revealed.

2 Case report

A 40-year old male, was referred to our observation presenting with hoarseness and dysphagia. Twenty days before he had sustained a car accident with trauma to the chest, the neck and the mandible. He had been submitted to a plain film of the chest, revealing the fractures of the 6th righ rib, the 6th and 7th left ribs.

Fiber laryngoscopy showed an immobile left vocal cord in the paramedian position compatible with left recurrent laryngeal nerve paralysis. Further otolaryngological examination showed no abnormality. The laboratory findings were normal. In the potential suspect of an aortic injury, the patient underwent contrast material-enhanced spiral computer tomography (CT) of the chest. Moreover, because of its superior capability in depiction of functional information regarding flow patterns and luminal communications, MR imaging of the chest was also performed. At CT, MR and angioMR imaging a post-traumatic aortic pseudoaneurysm was revealed: concomitant compression of the left broncus was shown as well (Fig. 1, 2). The aortic pseudoaneurysm was consequently repaired by implantation of an endovascular stent graft under local anesthesia. The patient was discharged 10 days later, and at the 3-years follow-up visit the hoarseness and the dysphonia had resolved completely.

Figure 1 Angio MRI: presence of pseudo-aneurysm of the descending thoracic aorta compressing the bronchus of the left and probably the left recurrent nerve. At the level of the origin of the descending thoracic enjoying a break from the intimate closed chest trauma.
Figure 1

Angio MRI: presence of pseudo-aneurysm of the descending thoracic aorta compressing the bronchus of the left and probably the left recurrent nerve. At the level of the origin of the descending thoracic enjoying a break from the intimate closed chest trauma.

Figure 2 Angio MRI: Evidence of the relationship between the vascular intimal rupture post-traumatic descending thoracic aorta and the pseudo-aneurysm formation.
Figure 2

Angio MRI: Evidence of the relationship between the vascular intimal rupture post-traumatic descending thoracic aorta and the pseudo-aneurysm formation.

Ethical approval: The research related to human use has been complied with all the relevant national regulations, institutional policies and in accordance the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.

Informed consent: Informed consent has been obtained from all individuals included in this study.

3 Discussion

The association of vocal cord dysfunction with thoracic aortic aneurysm has been reported in the cardiovascular and otolaryngologic literature [4,5,6,8,21-23]. The recurrent laryngeal nerve in its course from the brain stem to the larynx follows a path that brings it in proximity to numerous structures. These structures can interfere with its function by pressure or by disruption of the nerve caused by disease invading the nerve. Indeed, a recurrent laryngeal nerve paralysis can be related to multiple causes. Malignant neoplasms of the lung and pulmonary tuberco-losis are most frequent causes of the paralysis. Idiopathic paralysis are also very frequent; paralysis caused by thyroid surgery [2,3] and endotracheal intubation come next. Ortner’s syndrome [4], also known as cardiovocal syndrome, is a rare clinical entity that is manifested by hoarseness due to left recurrent laryngeal nerve palsy secondary to cardiovascular disease. Thoracic aortic aneurysms are usually asymptomatic [24,25]. In a retrospective study of 62 patients with thoracic aortic aneurysms, only one patient (1,6%) manifested hoarseness secondary to recurrent nerve palsy [26]. In case of aortic aneurysm, the incidence of left recurrence laryngeal nerve paralysis has been reported as 5% to 12 % [26-28]. Among unusual causes, post-traumatic pseudoaneurysms of the thoracic aorta presenting at a time remote from the original injury are a rare but complex problem. In patients with recurrent laryngeal nerve paralysis, the left recurrent nerve is most commonly involved with respect to the right laryngeal nerve [5]. Left recurrent laryngeal nerve paralysis has been reported in approximately 10% of patients who survive long enough to develop a pseudoaneurysm [6], but the time of onset has rarely been specified. Woodson [20] reported 50 cases of thoracic aortic trauma reviewed to determine the incidence and timing of laryngeal paralysis, and compared with 50 cases of atherosclerotic aneurysms matched for location. Four patients in the traumatic group were hoarse, and the onset was immediate in 3. Six in the atheroslerotic group became hoarse. Their results indicate that laryngeal paralysis following severe trauma can be a very early sign of aortic injury and requires prompt and thorough investigation [29,30]. Similarly, in the case of a delayed presentation of a post-traumatic vascular injury, rapid diagnose is of great importance, considering its unpredictable evolution. Razzouk et al. [15], reported 17 patients with pseudoaneurysm of the thoracic aorta. Four pseudoaneurysm developed post-trauma while 13 developed after aortic or cardiac surgery. The interval between initial operation and recognition of pseudoaneurysm varied from three months to eight years while the four post traumatic pseudoaneurysm presented 5 to 26 years post injury.

Information regarding the reversibility of hoarseness in cardiovocal syndrome after correction of the underlying cardiovascular disease is limited. Of those reported [7], 12 of 14 cases resolved within 1 week to 3 years, with a duration of preexisting hoarseness ranging from 1 month to 10 years. It appears that the recurrent nerve palsy in cardiovocal syndrome can be reversed: it depend on the degree and duration of palsy.

Also in our case, in whom symptoms and clinical evidence were revealed in a delayed phase (twenty days post-trauma), the anamnesis of a previous cervical blunt trauma was useful. Moreover, the patient presented with dysphonia, a very common symptom in patients with unilateral laryngeal paralysis. Finally, radiological imaging proved effective to yield the definitive diagnosis. In fact, in the past decade, CT and magnetic resonance imaging has been gradually assuming more importance in cardiovascular diagnosis [20]; advances in imaging methods also contributed to improved nonsurgical treatment of aortic pseudoaneurysms. Indeed, endovascular techniques are emerging as an alternative approach in the treatment of aortic disease, including post-traumatic aortic pseudoaneurysm [31-33]. A cell based therapy using Endothelial Progenitor Cells (EPCs) should be a possible revolutionary approach just used in several benign and malignant diseases [34-38]. EPCs biological properties are related to several biomarkers and pathogenic mechanisms involving Ca2+ related to vascular e non vascular pathologies [39-52].

4 Conclusion

In conclusion, the specialist should consider the diagnosis of Ortner’s syndrome after more common causes have been excluded, particularly in patients with cardiovascular disease. After trauma if the nerve is not damaged the hoarseness may be reversible once the pseudoaneurysm has been treated. Therefore, timely diagnosis and correction of the underlying disease is very important.

The definitive diagnosis of post-traumatic aortic pseudoaneurysm is now accomplished for the most part by using noninvasive imaging techniques. In patients who sustained major blunt chest or neck trauma presenting with hoarseness and dysphonia, a recurrent nerve palsy following post-traumatic aortic pseudoaneurysm must be included in the differential diagnosis.

Conflict of interest statement

Authors state no conflict of interest.

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Received: 2016-1-6
Accepted: 2016-3-7
Published Online: 2016-6-23
Published in Print: 2016-1-1

© 2016 Massimo Mesolella et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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  96. Laparoscopic antegrade cholecystectomy: a standard procedure?
  97. Case Report
  98. Maxillary fibrous dysplasia associated with McCune-Albright syndrome. A case study
  99. Regular Article
  100. Sialoendoscopy, sialography, and ultrasound: a comparison of diagnostic methods
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  102. Antibody Response to Live Attenuated Vaccines in Adults in Japan
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  108. Ectopic pregnancy treatment by combination therapy
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  112. Cusum analysis for learning curve of videothoracoscopic lobectomy
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  114. A meta-analysis of association between glutathione S-transferase M1 gene polymorphism and Parkinson’s disease susceptibility
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  118. Investigation and control of a suspected nosocomial outbreak of pan-drug resistant Acinetobacter baumannii in an intensive care unit
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  122. Smoking cessation for free: outcomes of a study of three Romanian clinics
  123. Regular Article
  124. Clinical efficacy and safety of tripterygium glycosides in treatment of stage IV diabetic nephropathy: A meta-analysis
  125. Special Issue on Italian Society for the Study of Vascular Anomalies
  126. Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature
  127. Special Issue on Italian Society for the Study of Vascular Anomalies
  128. Surgical treatment of recidivist lymphedema
  129. Special Issue on Italian Society for the Study of Vascular Anomalies
  130. CT and MR imaging of the thoracic aorta
  131. Special Issue on Italian Society for the Study of Vascular Anomalies
  132. Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma
  133. Special Issue on Italian Society for the Study of Vascular Anomalies
  134. Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome
  135. Special Issue on Italian Society for the Study of Vascular Anomalies
  136. Prenatal diagnosis, 3-D virtual rendering and lung sparing surgery by ligasure device in a baby with “CCAM and intralobar pulmonary sequestration”
  137. Special Issue on Italian Society for the Study of Vascular Anomalies
  138. Serum levels of inhibin B in adolescents after varicocelelectomy: A long term follow up
  139. Special Issue on Italian Society for the Study of Vascular Anomalies
  140. Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature
  141. Special Issue on Italian Society for the Study of Vascular Anomalies
  142. Delayed recurrent nerve paralysis following post-traumatic aortic pseudoaneurysm
  143. Special Issue on Italian Society for the Study of Vascular Anomalies
  144. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature
  145. Special Issue on Italian Society for the Study of Vascular Anomalies
  146. Celiac axis compression syndrome: laparoscopic approach in a strange case of chronic abdominal pain in 71 years old man
  147. Special Issue on Italian Society for the Study of Vascular Anomalies
  148. A rare case of persistent hypoglossal artery associated with contralateral proximal subclavian stenosis
  149. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  150. Contralateral risk reducing mastectomy in Non-BRCA-Mutated patients
  151. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  152. Professional dental and oral surgery liability in Italy: a comparative analysis of the insurance products offered to health workers
  153. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  154. Informed consent in robotic surgery: quality of information and patient perception
  155. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  156. Malfunctions of robotic system in surgery: role and responsibility of surgeon in legal point of view
  157. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  158. Medicolegal implications of surgical errors and complications in neck surgery: A review based on the Italian current legislation
  159. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  160. Iatrogenic splenic injury: review of the literature and medico-legal issues
  161. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  162. Donation of the body for scientific purposes in Italy: ethical and medico-legal considerations
  163. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  164. Cosmetic surgery: medicolegal considerations
  165. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  166. Voluntary termination of pregnancy (medical or surgical abortion): forensic medicine issues
  167. Review Article
  168. Role of Laparoscopic Splenectomy in Elderly Immune Thrombocytopenia
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  170. Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system
  171. Review Article
  172. Efficacy and safety of splenectomy in adult autoimmune hemolytic anemia
  173. Research Article
  174. Relationship between gastroesophageal reflux disease and Ph nose and salivary: proposal of a simple method outpatient in patients adults
  175. Case Report
  176. Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease
  177. Research Article
  178. Morbid Obesity: treatment with Bioenterics Intragastric Balloon (BIB), psychological and nursing care: our experience
  179. Research Article
  180. Learning curve for endorectal ultrasound in young and elderly: lights and shades
  181. Case Report
  182. Uncommon primary hydatid cyst occupying the adrenal gland space, treated with laparoscopic surgical approach in an old patient
  183. Research Article
  184. Distraction techniques for face and smile aesthetic preventing ageing decay
  185. Research Article
  186. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC
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  188. Descending necrotizing mediastinitis in the elderly patients
  189. Research Article
  190. Prophylactic GSV surgery in elderly candidates for hip or knee arthroplasty
  191. Research Article
  192. Diagnostic yield and safety of C-TBNA in elderly patients with lung cancer
  193. Research Article
  194. The learning curve of laparoscopic holecystectomy in general surgery resident training: old age of the patient may be a risk factor?
  195. Research Article
  196. Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients
  197. Research Article
  198. Anal sphincter dysfunction in multiple sclerosis: an observation manometric study
https://doi.org/10.1515/med-2016-0041
Schlagwörter für diesen Artikel
Recurrent nerve paralysis; aortic pseudoaneurysm; Ortner’s syndrome; cardiovocal syndrome
Creative Commons
BY-NC-ND 3.0

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  125. Special Issue on Italian Society for the Study of Vascular Anomalies
  126. Prevention and treatment of peritoneal adhesions in patients affected by vascular diseases following surgery: a review of the literature
  127. Special Issue on Italian Society for the Study of Vascular Anomalies
  128. Surgical treatment of recidivist lymphedema
  129. Special Issue on Italian Society for the Study of Vascular Anomalies
  130. CT and MR imaging of the thoracic aorta
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  132. Role of FDG-PET scan in staging of pulmonary epithelioid hemangioendothelioma
  133. Special Issue on Italian Society for the Study of Vascular Anomalies
  134. Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome
  135. Special Issue on Italian Society for the Study of Vascular Anomalies
  136. Prenatal diagnosis, 3-D virtual rendering and lung sparing surgery by ligasure device in a baby with “CCAM and intralobar pulmonary sequestration”
  137. Special Issue on Italian Society for the Study of Vascular Anomalies
  138. Serum levels of inhibin B in adolescents after varicocelelectomy: A long term follow up
  139. Special Issue on Italian Society for the Study of Vascular Anomalies
  140. Our experience in the treatment of Malignant Fibrous Hystiocytoma of the larynx: clinical diagnosis, therapeutic approach and review of literature
  141. Special Issue on Italian Society for the Study of Vascular Anomalies
  142. Delayed recurrent nerve paralysis following post-traumatic aortic pseudoaneurysm
  143. Special Issue on Italian Society for the Study of Vascular Anomalies
  144. Integrated therapeutic approach to giant solitary fibrous tumor of the pleura: report of a case and review of the literature
  145. Special Issue on Italian Society for the Study of Vascular Anomalies
  146. Celiac axis compression syndrome: laparoscopic approach in a strange case of chronic abdominal pain in 71 years old man
  147. Special Issue on Italian Society for the Study of Vascular Anomalies
  148. A rare case of persistent hypoglossal artery associated with contralateral proximal subclavian stenosis
  149. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  150. Contralateral risk reducing mastectomy in Non-BRCA-Mutated patients
  151. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  152. Professional dental and oral surgery liability in Italy: a comparative analysis of the insurance products offered to health workers
  153. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  154. Informed consent in robotic surgery: quality of information and patient perception
  155. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  156. Malfunctions of robotic system in surgery: role and responsibility of surgeon in legal point of view
  157. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  158. Medicolegal implications of surgical errors and complications in neck surgery: A review based on the Italian current legislation
  159. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  160. Iatrogenic splenic injury: review of the literature and medico-legal issues
  161. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  162. Donation of the body for scientific purposes in Italy: ethical and medico-legal considerations
  163. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
  164. Cosmetic surgery: medicolegal considerations
  165. Focus on Medico-Legal and Ethical Topics in Surgery in Italy
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  168. Role of Laparoscopic Splenectomy in Elderly Immune Thrombocytopenia
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  170. Endoscopic diagnosis and treatment of neuroendocrine tumors of the digestive system
  171. Review Article
  172. Efficacy and safety of splenectomy in adult autoimmune hemolytic anemia
  173. Research Article
  174. Relationship between gastroesophageal reflux disease and Ph nose and salivary: proposal of a simple method outpatient in patients adults
  175. Case Report
  176. Idiopathic pleural panniculitis with recurrent pleural effusion not associated with Weber-Christian disease
  177. Research Article
  178. Morbid Obesity: treatment with Bioenterics Intragastric Balloon (BIB), psychological and nursing care: our experience
  179. Research Article
  180. Learning curve for endorectal ultrasound in young and elderly: lights and shades
  181. Case Report
  182. Uncommon primary hydatid cyst occupying the adrenal gland space, treated with laparoscopic surgical approach in an old patient
  183. Research Article
  184. Distraction techniques for face and smile aesthetic preventing ageing decay
  185. Research Article
  186. Preoperative high-intensity training in frail old patients undergoing pulmonary resection for NSCLC
  187. Review Article
  188. Descending necrotizing mediastinitis in the elderly patients
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  190. Prophylactic GSV surgery in elderly candidates for hip or knee arthroplasty
  191. Research Article
  192. Diagnostic yield and safety of C-TBNA in elderly patients with lung cancer
  193. Research Article
  194. The learning curve of laparoscopic holecystectomy in general surgery resident training: old age of the patient may be a risk factor?
  195. Research Article
  196. Self-gripping mesh versus fibrin glue fixation in laparoscopic inguinal hernia repair: a randomized prospective clinical trial in young and elderly patients
  197. Research Article
  198. Anal sphincter dysfunction in multiple sclerosis: an observation manometric study
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