Startseite Medizin Preclinical antidiabetic and antioxidant effects of Erythrophleum africanum (benth.) harms in streptozotocin-induced diabetic nephropathy
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Preclinical antidiabetic and antioxidant effects of Erythrophleum africanum (benth.) harms in streptozotocin-induced diabetic nephropathy

  • Oluwafemi A. Ojo ORCID logo EMAIL logo , David Ajeigbe , Akingbolabo D. Ogunlakin , Olalekan E. Odesanmi , Mojisola Ayomipo , Godwin Berana , Peluola Ayeni , Omolola A. Ajayi-Odoko , Damilare I. Ayokunle , Adebola B. Ojo , Basiru O. Ajiboye , Omolara O. Ojo und Samuel O. Dahunsi
Veröffentlicht/Copyright: 3. Juli 2024
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 21 Heft 3

Abstract

Objectives

This study investigated the antidiabetic effects of the methanolic extract of E. africanum (MEEA) stem bark on streptozotocin (STZ)-induced diabetic nephropathy (DN) in Wistar rats.

Methods

The in vitro enzyme (α-amylase) inhibitory activity of MEEA was measured using a standard procedure. Diabetic rats with fasting blood glucose above 250 mg/dL were considered diabetic and were divided into the following groups: control (distilled water-treated), diabetic-control, diabetic metformin (100 mg/kg), diabetes + MEEA (150 mg/kg), and diabetes + MEEA (300 mg/kg) via oral gavage once daily for 14 days. At the end of the experimental period, kidney tissues were collected for biochemical and histological analyses. Kidney apoptosis and marker gene expression were measured by real-time quantitative PCR.

Results

MEEA exhibited α-amylase inhibitory effects. MEEA significantly (p<0.05) reduced the STZ-induced increases in blood glucose, serum urea, serum creatinine, uric acid, alanine aminotransferase, alkaline phosphatase, and malondialdehyde and increased the STZ-induced decreases in superoxide dismutase, catalase, and reduced glutathione. In addition, MEEA protects against DN by significantly downregulating the mRNA expression of cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), cAMP-response binding protein (CREB), and cFOS and upregulating B-cell lymphoma 2 (Bcl-2), suggesting that the nephroprotective ability of MEEA is due to the modulation of the cAMP/PKA/CREB/cFOS signaling pathway. Furthermore, MEEA treatment protected against histopathological alterations observed in diabetic rats.

Conclusions

The data from this study suggest that MEEA modulates glucose homeostasis and inhibits redox imbalance in DN rats.

Keywords: diabetic nephropathy; Erythrophleum africanum ; oxidative stress; drug discovery; signaling pathway
Corresponding author: Oluwafemi A. Ojo, Good Health and Wellbeing Research Clusters (SDG 03), Bowen University, Iwo, Nigeria; and Biochemistry Programme, 70671 Phytomedicine, Molecular Toxicology, and Computational Biochemistry Research Laboratory (PMTCB-RL), Bowen University , Iwo, 232101, Nigeria, E-mail:

  1. Research ethics: All experimental protocols were approved by the Bowen University Animal Ethics Committee (BUAC/BCH/2023/0004A). All methods were carried out in accordance with the US guidelines (NIH publication #85-23, revised in 1985) and all methods are reported in accordance with ARRIVE guidelines.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors declare no conflicts of interest.

  5. Research funding: No funding was received for this study.

  6. Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jcim-2024-0090).

Received: 2024-03-26
Accepted: 2024-06-16
Published Online: 2024-07-03

© 2024 Walter de Gruyter GmbH, Berlin/Boston

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  15. Effect of horticultural therapy on static, dynamic balance and gait speed among institutionalized older adults with cognitive impairment
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https://doi.org/10.1515/jcim-2024-0090
Schlagwörter für diesen Artikel
diabetic nephropathy; Erythrophleum africanum; oxidative stress; drug discovery; signaling pathway

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential
  4. Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
  5. Research Articles
  6. Phytochemical characterisation and toxicity effect of Tithonia diversifolia (Hemls.) A. Gray leaf extract on fall army worm Spodoptera frugiperda (JE Smith) larvae
  7. Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models
  8. Evaluation of anti-nociceptive and anti-inflammatory activities of solvent fraction of the roots of Echinops kebericho Mesfin (Asteraceae) in mice model
  9. A spectrometric analysis of variedly purified cinnabar in a siddha drug – linga chendhooram
  10. Palm oil amends serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats
  11. Brazil nuts potential: effects on lipid peroxidation and heart health in nephrectomized rats
  12. Preclinical antidiabetic and antioxidant effects of Erythrophleum africanum (benth.) harms in streptozotocin-induced diabetic nephropathy
  13. Pharmacognostical characterization, GC-MS profiling, and elemental analysis of Curcuma caesia Roxb. rhizomes for public health
  14. Antibacterial activity of Macrosciadium alatum (M.Bieb.) plant extract
  15. Effect of horticultural therapy on static, dynamic balance and gait speed among institutionalized older adults with cognitive impairment
  16. Anti-hyperlipidemic effects of 500 mg spilanthol (SA3X) supplementation in people with dyslipidemia – a randomized, parallel-group placebo-controlled trial
  17. Potential biomarkers of ASD a target for future treatments: oxidative stress, chemokines, apoptotic, and methylation capacity
  18. Therapeutic ayurvedic interventions for the management of rheumatoid arthritis complicated by adhesive capsulitis – a case report
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