Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models
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Agik Priyo Nusantoro
,
Kuntaman Kuntaman
und
David Sontani Perdanakusuma
Abstract
Wounds in diabetes is a complex problem that requires effective treatment at a high cost. Adjuvant therapy from natural bioactive elements can be an alternative to overcome problems in diabetic wound healing disorders. Allicin and quercetin are natural bioactive substances contained in several fruit or vegetable plants that have various pharmacological effects. The purpose of this study was to determine the effect of allicin and quercetin in emulsion form as wound medicine in helping the wound healing process. Diabetic wistar rats with wounds on their backs measuring 1 × 1 cm were divided into four treatment groups which were given wound medicine once a day for seven days according to their distribution. The wound healing process was evaluated on the third and seventh day. Data were observed and analyzed using appropriate statistical tools. Measurement of wound healing indicators was carried out by examining wound contraction and histopathological examination showing that the treatment group given the allicin and quercetin formula experienced an improvement compared to the treatment group without allicin and quercetin. Allicin and quercetin increase the percentage of wound contraction, increase the density of blood vessels and the epithelialization process in the wound so that the wound healing process becomes faster. In conclusion, allicin and quercetin can be effective adjuvant therapies in helping wound healing in diabetes. Wound medication in the form of an emulsion is an effective choice, because it can maintain the stability of the allicin and quercetin content and can make the wound environment moist.
Funding source: Lembaga Pengelola Dana Pendidikan
Award Identifier / Grant number: FR10112021272978
Acknowledgment
The author would like to thank the Department of Pharmacy, Kusuma Husada University, Surakarta, for assisting in the preparation of this research formula. The author would like to thank the Department of Anatomical Pathology Laboratory, Airlangga University, Surabaya, Indonesia, which has assisted in carrying out histopathological examination and assessment. This study was supported by the Education Fund Management Institute (LPDP), Ministry of National Finance, Indonesia.
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Research ethics: Not applicable in accordance with the Declaration of Helsinki because the samples in the research were experimental animals so all experimental protocols followed the guidelines approved by the Animal Ethics Commission, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia No: 2.KEH. 005.02.2022.
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Informed consent: Not applicable.
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Author contributions: APN: designing manuscripts, compiling and writing manuscripts, interpreting data, looking for references. KK: designing manuscripts, studying concepts and designs, and revising critical manuscripts for important intellectual content. DSP: studying manuscript design, data interpretation and revision of critical manuscripts for important intellectual content. The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: This research was funded by the Education Fund Management Institute (LPDP), Ministry of National Finance, Indonesia [funding number: FR10112021272978].
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Data availability: The data used to support the findings of this research are included within the article.
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models
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- Antibacterial activity of Macrosciadium alatum (M.Bieb.) plant extract
- Effect of horticultural therapy on static, dynamic balance and gait speed among institutionalized older adults with cognitive impairment
- Anti-hyperlipidemic effects of 500 mg spilanthol (SA3X) supplementation in people with dyslipidemia – a randomized, parallel-group placebo-controlled trial
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential
- Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
- Research Articles
- Phytochemical characterisation and toxicity effect of Tithonia diversifolia (Hemls.) A. Gray leaf extract on fall army worm Spodoptera frugiperda (JE Smith) larvae
- Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models
- Evaluation of anti-nociceptive and anti-inflammatory activities of solvent fraction of the roots of Echinops kebericho Mesfin (Asteraceae) in mice model
- A spectrometric analysis of variedly purified cinnabar in a siddha drug – linga chendhooram
- Palm oil amends serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats
- Brazil nuts potential: effects on lipid peroxidation and heart health in nephrectomized rats
- Preclinical antidiabetic and antioxidant effects of Erythrophleum africanum (benth.) harms in streptozotocin-induced diabetic nephropathy
- Pharmacognostical characterization, GC-MS profiling, and elemental analysis of Curcuma caesia Roxb. rhizomes for public health
- Antibacterial activity of Macrosciadium alatum (M.Bieb.) plant extract
- Effect of horticultural therapy on static, dynamic balance and gait speed among institutionalized older adults with cognitive impairment
- Anti-hyperlipidemic effects of 500 mg spilanthol (SA3X) supplementation in people with dyslipidemia – a randomized, parallel-group placebo-controlled trial
- Potential biomarkers of ASD a target for future treatments: oxidative stress, chemokines, apoptotic, and methylation capacity
- Therapeutic ayurvedic interventions for the management of rheumatoid arthritis complicated by adhesive capsulitis – a case report
