Startseite Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
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Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer

  • Neha Masarkar , Suman Kumar Ray , Zirha Saleem und Sukhes Mukherjee EMAIL logo
Veröffentlicht/Copyright: 18. September 2023
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 21 Heft 3

Abstract

Breast cancer (BC) will become a highly detected malignancy in females worldwide in 2023, with over 2 million new cases. Studies have established the role of hypoxia-inducible factor-1α (HIF1α), a transcription factor that controls cellular response to hypoxic stress, and is essential for BC spread. HIF-1 is implicated in nearly every critical stage of the metastatic progression, including invasion, EMT, intravasation, extravasation, angiogenesis, and the formation of metastatic niches. HIF-1 overexpression has been associated with poor prognosis and increased mortality in BC patients. This is accomplished by controlling the expression of HIF-1 target genes involved in cell survival, angiogenesis, metabolism, and treatment resistance. Studies have indicated that inhibiting HIF-1 has an anti-cancer effect on its own and that inhibiting HIF-1-mediated signaling improves the efficacy of anti-cancer therapy. Approximately 74 % of recognized anti-cancer drugs are sourced from plant species. Studies on anti-cancer characteristics of phytochemicals derived from Moringa oleifera (MO), also known as the ‘Tree of Life’, have revealed a high therapeutic potential for BC. In this review, we have highlighted the various mechanisms through which bioactive compounds present in MO may modulate HIF and its regulatory genes/pathways, to prove their efficacy in treating and preventing BC.

Keywords: breast cancer; bio-active compounds; hypoxia; HIF; Moringa oleifera ; phytochemicals
Corresponding author: Dr. Sukhes Mukherjee, Additional Professor, Department of Biochemistry, All India Institute of Medical Sciences Bhopal, 3rd Floor, Medical College Building, Saket Nagar, Bhopal 462020, Madhya Pradesh, India, Phone: +91 9897800194, E-mail:
Neha Masarkar and Suman Kumar Ray contributed equally to this work.

  1. Ethical approval: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: Not applicable.

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Received: 2023-07-12
Accepted: 2023-08-13
Published Online: 2023-09-18

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential
  4. Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
  5. Research Articles
  6. Phytochemical characterisation and toxicity effect of Tithonia diversifolia (Hemls.) A. Gray leaf extract on fall army worm Spodoptera frugiperda (JE Smith) larvae
  7. Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models
  8. Evaluation of anti-nociceptive and anti-inflammatory activities of solvent fraction of the roots of Echinops kebericho Mesfin (Asteraceae) in mice model
  9. A spectrometric analysis of variedly purified cinnabar in a siddha drug – linga chendhooram
  10. Palm oil amends serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats
  11. Brazil nuts potential: effects on lipid peroxidation and heart health in nephrectomized rats
  12. Preclinical antidiabetic and antioxidant effects of Erythrophleum africanum (benth.) harms in streptozotocin-induced diabetic nephropathy
  13. Pharmacognostical characterization, GC-MS profiling, and elemental analysis of Curcuma caesia Roxb. rhizomes for public health
  14. Antibacterial activity of Macrosciadium alatum (M.Bieb.) plant extract
  15. Effect of horticultural therapy on static, dynamic balance and gait speed among institutionalized older adults with cognitive impairment
  16. Anti-hyperlipidemic effects of 500 mg spilanthol (SA3X) supplementation in people with dyslipidemia – a randomized, parallel-group placebo-controlled trial
  17. Potential biomarkers of ASD a target for future treatments: oxidative stress, chemokines, apoptotic, and methylation capacity
  18. Therapeutic ayurvedic interventions for the management of rheumatoid arthritis complicated by adhesive capsulitis – a case report
https://doi.org/10.1515/jcim-2023-0182
Schlagwörter für diesen Artikel
breast cancer; bio-active compounds; hypoxia; HIF; Moringa oleifera; phytochemicals

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Boldine: a narrative review of the bioactive compound with versatile biological and pharmacological potential
  4. Potential anti-cancer activity of Moringa oleifera derived bio-active compounds targeting hypoxia-inducible factor-1 alpha in breast cancer
  5. Research Articles
  6. Phytochemical characterisation and toxicity effect of Tithonia diversifolia (Hemls.) A. Gray leaf extract on fall army worm Spodoptera frugiperda (JE Smith) larvae
  7. Management of wounds in diabetes by administering allicin and quercetin in emulsion form as wound medicine in diabetic rat models
  8. Evaluation of anti-nociceptive and anti-inflammatory activities of solvent fraction of the roots of Echinops kebericho Mesfin (Asteraceae) in mice model
  9. A spectrometric analysis of variedly purified cinnabar in a siddha drug – linga chendhooram
  10. Palm oil amends serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats
  11. Brazil nuts potential: effects on lipid peroxidation and heart health in nephrectomized rats
  12. Preclinical antidiabetic and antioxidant effects of Erythrophleum africanum (benth.) harms in streptozotocin-induced diabetic nephropathy
  13. Pharmacognostical characterization, GC-MS profiling, and elemental analysis of Curcuma caesia Roxb. rhizomes for public health
  14. Antibacterial activity of Macrosciadium alatum (M.Bieb.) plant extract
  15. Effect of horticultural therapy on static, dynamic balance and gait speed among institutionalized older adults with cognitive impairment
  16. Anti-hyperlipidemic effects of 500 mg spilanthol (SA3X) supplementation in people with dyslipidemia – a randomized, parallel-group placebo-controlled trial
  17. Potential biomarkers of ASD a target for future treatments: oxidative stress, chemokines, apoptotic, and methylation capacity
  18. Therapeutic ayurvedic interventions for the management of rheumatoid arthritis complicated by adhesive capsulitis – a case report
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