Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism
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Khaled Mohamed Mohamed Koriem
und
Marwa A. El-Attar
Abstract
Objectives
Favism is a metabolic disease and this study aimed to compare between olive oil and almond oil to ameliorate blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology in favism rats.
Methods
Animals were 36 male albino rats. They classified to 2 equal (normal and favism) groups. Normal group classified to 3 equal subgroups; Control, Olive oil, and Almond oil subgroups: normal rats orally administrated with 1 mL/100 g of saline, olive oil, and almond oil, respectively. Favism group was subdivided into 3 equal subgroup; favism, favism + olive oil, and favism + almond oil subgroups: favism rats orally administrated with no treatment, 1 mL/100 g olive oil, and 1 mL/100 g almond oil, respectively. All treatments were administrated orally by oral gavage once a day for 1 month.
Results
The hemoglobin, hematocrite, the blood cells, glucose and glucose-6-phosphate dehydrogenase, aspartate and alanine aminotransferase, total proteins, albumin, and globulin in serum were decreased in favism. The glutathione, superoxide dismutase, and glutathione peroxidase in blood and liver were decreased in favism while alkaline phosphatase and total bilirubin in serum were increased in favism. The blood and liver malondialdehyde was increased in favism. Furthermore, oral administration with both oils in favism rats restored all these parameters to be approached the control levels. Also, both oils preserved blood and liver DNA and liver histology.
Conclusions
Almond oil restored blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism.
Acknowledgments
There is no acknowledgment for this research.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The local Institutional Review Board deemed the study exempt from review.
References
1. McMillan, DC, Jollow, DJ. Favism: divicine hemotoxicity in the rat. Toxicol Sci 1999;51:310–6. https://doi.org/10.1093/toxsci/51.2.310.Suche in Google Scholar
2. Bicakci, Z. A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (vetch). Saudi Med J 2009;30:292–4.Suche in Google Scholar
3. Arese, P, Mannuzzu, L, Turrini, F. Pathophysiology of favism. Folia Haematol 1989;116:745–52.Suche in Google Scholar
4. Albano, E, Tomasi, A, Mannuzzu, L, Arese, P. Detection of free radical intermediate from divicine of Vicia faba. Biochem Pharmacol 1984;33:1701–4. https://doi.org/10.1016/0006-2952(84)90299-5.Suche in Google Scholar
5. Marquardt, RR. Vicine, convicine and their role aglycnes-divine and isouramil. In: Cheeke, P, editor. Toxicants of plant origin, 2nd ed. Boca Raton, F l., New York, USA: CRC Press; 1989:614–23 pp.Suche in Google Scholar
6. Majumder, D, Debnath, M, Sharma, KN, Shekhawat, SS, Prasad, GBKS, Maiti, D, et al.. Olive oil consumption can prevent non-communicable diseases and COVID-19: a Review. Curr Pharmaceut Biotechnol 2022;23:261–75. https://doi.org/10.2174/1389201022666210412143553.Suche in Google Scholar PubMed
7. Guasch-Ferré, M, Li, Y, Willett, WC, Sun, Q, Sampson, L, Salas-Salvadó, J, et al.. Consumption of olive oil and risk of total and cause-specific mortality among U.S. adults. J Am Coll Cardiol 2022;79:101–12. https://doi.org/10.1016/j.jacc.2021.10.041.Suche in Google Scholar PubMed PubMed Central
8. Markellos, C, Ourailidou, ME, Gavriatopoulou, M, Halvatsiotis, P, Sergentanis, TN, Psaltopoulou, T. Olive oil intake and cancer risk: a systematic review and meta-analysis. PLoS One 2022;17:e0261649. https://doi.org/10.1371/journal.pone.0261649.Suche in Google Scholar PubMed PubMed Central
9. Moral, R, Escrich, E. Influence of olive oil and its components on breast cancer: molecular mechanisms. Molecules 2022;27:477. https://doi.org/10.3390/molecules27020477.Suche in Google Scholar PubMed PubMed Central
10. Ouzir, M, Bernoussi, SE, Tabyaoui, M, Taghzouti, K. Almond oil: a comprehensive review of chemical composition, extraction methods, preservation conditions, potential health benefits, and safety. Compr Rev Food Sci Food Saf 2021;20:3344–87. https://doi.org/10.1111/1541-4337.12752.Suche in Google Scholar PubMed
11. Schincaglia, RM, Pimentel, GD, Peixoto, MDRG, Cuppari, L, Mota, JF. The effect of Baru (Dypterix alata vog.) almond oil on markers of bowel habits in hemodialysis patients. Evid Based Complement Alternat Med 2021;2021:3187305, https://doi.org/10.1155/2021/3187305.Suche in Google Scholar PubMed PubMed Central
12. Li, JN, Henning, SM, Thames, G, Bari, O, Tran, PT, Tseng, CH, et al.. Almond consumption increased UVB resistance in healthy Asian women. J Cosmet Dermatol 2021;20:2975–80. https://doi.org/10.1093/cdn/nzab037_029.Suche in Google Scholar
13. Koriem, KMM, Arbid, MSS, El-Gendy, NF. The protective role of anise oil in oxidative stress and genotoxicity produced in favism. J Diet Suppl 2016;13:505–21. https://doi.org/10.3109/19390211.2015.1119775.Suche in Google Scholar PubMed
14. Koriem, KMM, Arbid, MSS. Evaluating of β-carotene role in ameliorating of favism-induced disturbances in blood and testis. J Compl Integr Med 2018;20170164:1–11. https://doi.org/10.1515/jcim-2017-0164.Suche in Google Scholar PubMed
15. Koriem, KMM, Arbid, MSS. Pickled olives neutralize vicine and convicine glycosides in Vicia faba and protect from favism. Nutr Food Sci 2021;51:959–73. https://doi.org/10.1108/nfs-10-2020-0394.Suche in Google Scholar
16. El-Shabrawy, OAM. Toxicological studies on Vicia faba in laboratory animals. M.Sc. thesis medical jurisprudence. Egypt: Alexandria University; 1971:86–91 pp.Suche in Google Scholar
17. Behren, W, Karber, G. Determination of LD50. Arch Exp Pathol Pharmacol 1953;2:177–277.Suche in Google Scholar
18. Jahn, NH. Nutritional toxicology. New York, USA: Academic Press; 1982:28–31 pp.Suche in Google Scholar
19. Uthus, EO. The effect on arsenic deprivation in rats of diethyl maleate, an in vivo chemical depletory of glutathione. Proc New Drugs: Acad Sci Technol 1992;46:70–5.Suche in Google Scholar
20. Liu, H, Huang, H, Li, B, Wu, D, Wang, F, Zheng, X, et al.. Olive oil in the prevention and treatment of osteoporosis after artificial menopause. Clin Interv Aging 2014;9:2087–95. https://doi.org/10.2147/cia.s72006.Suche in Google Scholar PubMed PubMed Central
21. Danque, PD, Chen, HB, Patil, J, Jagirdar, J, Orsatti, G, Paronetto, F. Image analysis versus ow cytometry for DNA ploidy quantitation of solid tumors; a comparison of six methods of sample preparation. Mod Pathol 1993;6:270–5.Suche in Google Scholar
22. Darzynkiewicz, Z, Huang, X, Zhao, H. Analysis of cellular DNA content by flow cytometry. Curr Protoc Im 2017;119:5.7.1–20. https://doi.org/10.1002/cpim.36.Suche in Google Scholar PubMed
23. Darzynkiewicz, Z, Huang, X, Zhao, H. Analysis of cellular DNA content by flow cytometry. Curr Protoc Cytom 2017;82:7.5.1–20.10.1002/cpcy.28Suche in Google Scholar PubMed
24. Stamatoyannopoulos, G, Fraser, GR, Motulsky, AG, Fessas, P, Akrivakis, A, Papayannopoulou, T. On the familial predisposition to favism. Am J Hum Genet 1966;18:253–63.Suche in Google Scholar
25. Lin, JY, Ling, KFL. Studies on Favism I. Isolation of an active principle from faba beans (Vicia faba L.). J Formos Med Assoc 1962;61:484–8.Suche in Google Scholar
26. Hegazy, MI, Marquardt, RR. Metabolism of vicine and convicine in rat tissues: absorption and excretion patterns and site of hydrolysis. J Sci Food Agric 1984;35:139–46. https://doi.org/10.1002/jsfa.2740350204.Suche in Google Scholar PubMed
27. Belsey, MA. The epidemiology of favism. Bull World Health Organ 1973;48:1–13.Suche in Google Scholar
28. Arbid, MSS, Marquardt, RR. Favism-like effects of divicine and isouramil in the rat: acute and chronic effects on animal health, mortalities, blood parameters and ability to exchange respiratory gases. J Sci Food Agric 1988;43:75–90. https://doi.org/10.1002/jsfa.2740430110.Suche in Google Scholar
29. Koriem, KMM, Megahed, HA, Arbid, MS. Evaluation of some adverse effects of the glycoside convicine in Sprague-Dawley rats. Toxicol Environ Chem 2008;90:415–20. https://doi.org/10.1080/02772240701483855.Suche in Google Scholar
30. Arbid, MS, Koriem, KMM, Asaad, GF, Megahed, HA. Effect of the antibiotic neomycin on the toxicity of the glycoside vicine in rats. J Toxicol 2013;2013:913128-1–8. https://doi.org/10.1155/2013/913128.Suche in Google Scholar PubMed PubMed Central
31. Marquardt, RR, Wang, N, Arbid, MSS. Pyrimidine glycosides, chapter 10. In: D’Mello, JOF, editor. Handbook of plant and fungal toxicants. Boca Raton, FL, 33431, USA: CRC Press, Inc.; 1997:139–55 pp.10.1201/9780429281952-10Suche in Google Scholar
32. Capó, X, Martorell, M, Busquets-Cortés, C, Sureda, A, Riera, J, Drobnic, F, et al.. Effects of dietary almond- and olive oil-based docosahexaenoic acid- and vitamin E-enriched beverage supplementation on athletic performance and oxidative stress markers. Food Funct 2016;7:4920–34. https://doi.org/10.1039/c6fo00758a.Suche in Google Scholar PubMed
33. Amamou, F, Nemmiche, S, Meziane, RK, Didi, A, Yazit, SM, Chabane-Sari, D. Protective effect of olive oil and colocynth oil against cadmium-induced oxidative stress in the liver of wistar rats. Food Chem Toxicol 2015;78:177–84. https://doi.org/10.1016/j.fct.2015.01.001.Suche in Google Scholar PubMed
34. Torres, LR, Santana, FC, Torres-Leal, FL, Melo, IL, Yoshime, LT, Matos-Neto, EM, et al.. Pequi (caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: antioxidant and anti-inflammatory effects. Food Chem Toxicol 2016;97:205–16. https://doi.org/10.1016/j.fct.2016.09.009.Suche in Google Scholar PubMed
35. Loffredo, L, Ben, MD, Bartimoccia, S, Castellani, V, Mancinella, M, Ciacci, P, et al.. Chocolate enriched by extra virgin olive oil improves endothelial function and oxidative stress in patients with diabetes. Nutrition 2021;90:111270. https://doi.org/10.1016/j.nut.2021.111270.Suche in Google Scholar PubMed
36. Zhang, M, Song, G, Minuk, GY. Effects of hepatic stimulator substance, herbal medicine, selenium/vitamin E, and ciprofluoxacin on cirrhosis in the rat. Gastroenterology 1996;110:1150–5. https://doi.org/10.1053/gast.1996.v110.pm8613004.Suche in Google Scholar PubMed
37. Koriem, KMM. Proteomic approach in human health and disease: preventive and cure studies. Asian Pac J Trop Biomed 2018;8:226–36. https://doi.org/10.4103/2221-1691.231285.Suche in Google Scholar
38. Koriem, KMM. A lipidomic concept in infectious diseases. Asian Pac J Trop Biomed 2017;7:265–74. https://doi.org/10.1016/j.apjtb.2016.12.010.Suche in Google Scholar
39. Beutler, E. Hemolytic anemia in disorders of red cell metabolism. In: Win- trobe, MM, editor. Topics in hematology. New York: Plenum Publishing; 1978:199–209 pp.10.1007/978-1-4684-2457-7Suche in Google Scholar
40. Koriem, KMM. Protective effect of natural products and hormones in colon cancer using metabolome: a physiological overview. Asian Pac J Trop Biomed 2017;7:957–66. https://doi.org/10.1016/j.apjtb.2017.09.002.Suche in Google Scholar
41. Nascimento-Silva, NRRD, Naves, MMV. Potential of whole pequi (caryocar spp.) fruit-pulp, almond, oil, and shell-as a medicinal food. J Med Food 2019;22:952–62. https://doi.org/10.1089/jmf.2018.0149.Suche in Google Scholar PubMed
42. Al-Seeni, MN, El Rabey, HA, Zamzami, MA, Alnefayee, AM. The hepatoprotective activity of olive oil and Nigella sativa oil against CCl(4) induced hepatotoxicity in male rats. BMC Compl Altern Med 2016;16:438. https://doi.org/10.1186/s12906-016-1422-4.Suche in Google Scholar PubMed PubMed Central
43. Habibi, E, Baâti, T, Njim, L, M’Rabet, Y, Hosni, K. Antioxidant and protective effects of extra virgin olive oil incorporated with diallyl sulfide against CCl(4)-induced acute liver injury in mice. Food Sci Nutr 2021;9:6818–30. https://doi.org/10.1002/fsn3.2638.Suche in Google Scholar PubMed PubMed Central
44. Koriem, KMM, Arbid, MSS. Vitamin E ameliorates disturbances in testosterone pathway and sperm quality of male rats induced by the glycosides vicine and convicine of Vicia faba. Nutr Food Sci 2022;52:61–74. https://doi.org/10.1108/nfs-02-2021-0053.Suche in Google Scholar
45. Roberti, SL, Higa, R, Sato, H, Gomez Ribot, D, Capobianco, E, Jawerbaum, A. Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offsprings heart of diabetic rats. Reprod Toxicol 2020;95:137–47. https://doi.org/10.1016/j.reprotox.2020.05.002.Suche in Google Scholar PubMed
46. Zorić, N, Kopjar, N, Rodriguez, JV, Tomić, S, Kosalec, I. Protective effects of olive oil phenolics oleuropein and hydroxytyrosol against hydrogen peroxide-induced DNA damage in human peripheral lymphocytes. Acta Pharm 2021;71:131–41. https://doi.org/10.2478/acph-2021-0003.Suche in Google Scholar PubMed
47. Magosso, MF, Carvalho, PC, Shneider, BU, Pessatto, LR, Pesarini, JR, Silva, PV, et al.. Acrocomia aculeata prevents toxicogenetic damage caused by the antitumor agent cyclophosphamide. Genet Mol Res 2016;15:1–14.10.4238/gmr.15027816Suche in Google Scholar PubMed
© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- Evidence implementation among complementary medicine practitioners: a meta-summary
- Phytochemical: a treatment option for heavy metal induced neurotoxicity
- The effects of curcumin-containing supplementations on inflammatory markers and lipid profiles in patients with chronic kidney diseases: a systematic review and meta-analysis of randomized controlled trials
- A systematic review on traditional medicinal Animal’s parts and products used for the treatment of respiratory tract disorders in Ethiopia
- Review on nutraceuticals: phase transition from preventive to protective care
- A study of effect of Centella asiatica on oxidative markers in the hippocampus of offsprings born to alcohol-fed pregnant rats and the correlation with their cognitive functions
- Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice
- Research Articles
- Comparison of antithyroid effects and hepatic complications of methimazole with catechin and its nanoencapsulation form in adult male rats
- Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism
- Highly efficient microencapsulation of phytonutrients by fractioned cellulose using biopolymer complexation technology
- Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model
- Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats
- Assessment of anti-inflammatory and antioxidant activity of quercetin–rutin blend (SophorOx™) – an invitro cell based assay
- Subchronic toxicological evaluation of EnXtra™ (standardised extract of Alpinia galanga rhizome) in rats
- Ficus glumosa Del. reduces phenylhydrazine-induced hemolytic anaemia and hepatic damage in Wistar rats
- Screening of anti-cancerous potential of classical Raudra rasa and modified Raudra rasa modified with hiraka bhasma (nanodiamond) through FTIR & LC-MS analysis
- Aqueous extract of Pedalium murex D. Royen ex L. leafy stem protects against lead induced testicular toxicity in Wistar rats
- Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze
- Developmental effects of early-life stress on dopamine D2 receptor and proteins involved in noncanonical D2 dopamine receptor signaling pathway in the prefrontal cortex of male rats
- Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei
- Acacia arabica (Lam.) Willd. On osteoblastogenesis, osteoblast proliferation, osteoclastic activity, and bone calcium mineralization
- GC-MS analysis of curculigo orchiodes and medicinal herbs with cytotoxic, hepatoprotective attributes of ethanolic extract from Indian origin
- Biochemical and histopathological evaluation of liver, kidney, and pancreas in normal Sprague Dawley rats administered aqueous extract of beetroot (Beta vulgaris)
- The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial
- The formulation and efficacy of topical Dorema ammoniacum in treating Melasma: a randomized double-blind, placebo-controlled trial
- Impact of inhalation aromatherapy with Damask Rose (Rosa damascena) on stress, anxiety and hemodynamic parameters of patients undergoing coronary angiography: a single blind randomized clinical trial
- Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silico analysis
- Prophylactic management of radiation-induced mucositis using herbal mouthwash in patients with head and neck cancer: an assessor-blinded randomized controlled trial
- Implementation science in New Zealand naturopathic practice: a cross-sectional study
- Issues of mindfulness implementation for oncology caregivers
- Immediate effect of cold mud pack therapy on autonomic variables in primary hypertensive individuals: a randomized trial
- Effect of a Persian metabolic diet on the functional dyspepsia symptoms in patients with postprandial distress syndrome: a randomized, double-blind clinical trial
Artikel in diesem Heft
- Frontmatter
- Reviews
- Evidence implementation among complementary medicine practitioners: a meta-summary
- Phytochemical: a treatment option for heavy metal induced neurotoxicity
- The effects of curcumin-containing supplementations on inflammatory markers and lipid profiles in patients with chronic kidney diseases: a systematic review and meta-analysis of randomized controlled trials
- A systematic review on traditional medicinal Animal’s parts and products used for the treatment of respiratory tract disorders in Ethiopia
- Review on nutraceuticals: phase transition from preventive to protective care
- A study of effect of Centella asiatica on oxidative markers in the hippocampus of offsprings born to alcohol-fed pregnant rats and the correlation with their cognitive functions
- Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice
- Research Articles
- Comparison of antithyroid effects and hepatic complications of methimazole with catechin and its nanoencapsulation form in adult male rats
- Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism
- Highly efficient microencapsulation of phytonutrients by fractioned cellulose using biopolymer complexation technology
- Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model
- Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats
- Assessment of anti-inflammatory and antioxidant activity of quercetin–rutin blend (SophorOx™) – an invitro cell based assay
- Subchronic toxicological evaluation of EnXtra™ (standardised extract of Alpinia galanga rhizome) in rats
- Ficus glumosa Del. reduces phenylhydrazine-induced hemolytic anaemia and hepatic damage in Wistar rats
- Screening of anti-cancerous potential of classical Raudra rasa and modified Raudra rasa modified with hiraka bhasma (nanodiamond) through FTIR & LC-MS analysis
- Aqueous extract of Pedalium murex D. Royen ex L. leafy stem protects against lead induced testicular toxicity in Wistar rats
- Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze
- Developmental effects of early-life stress on dopamine D2 receptor and proteins involved in noncanonical D2 dopamine receptor signaling pathway in the prefrontal cortex of male rats
- Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei
- Acacia arabica (Lam.) Willd. On osteoblastogenesis, osteoblast proliferation, osteoclastic activity, and bone calcium mineralization
- GC-MS analysis of curculigo orchiodes and medicinal herbs with cytotoxic, hepatoprotective attributes of ethanolic extract from Indian origin
- Biochemical and histopathological evaluation of liver, kidney, and pancreas in normal Sprague Dawley rats administered aqueous extract of beetroot (Beta vulgaris)
- The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial
- The formulation and efficacy of topical Dorema ammoniacum in treating Melasma: a randomized double-blind, placebo-controlled trial
- Impact of inhalation aromatherapy with Damask Rose (Rosa damascena) on stress, anxiety and hemodynamic parameters of patients undergoing coronary angiography: a single blind randomized clinical trial
- Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silico analysis
- Prophylactic management of radiation-induced mucositis using herbal mouthwash in patients with head and neck cancer: an assessor-blinded randomized controlled trial
- Implementation science in New Zealand naturopathic practice: a cross-sectional study
- Issues of mindfulness implementation for oncology caregivers
- Immediate effect of cold mud pack therapy on autonomic variables in primary hypertensive individuals: a randomized trial
- Effect of a Persian metabolic diet on the functional dyspepsia symptoms in patients with postprandial distress syndrome: a randomized, double-blind clinical trial
