Abstract
Nutraceuticals are essential for healthcare which is an alternative medicine that has gained popularity in recent years. Nutraceuticals consist of nutrients, herbals, and dietary supplements, which make them useful in preserving and promoting health, fighting illness, and improving overall quality of life. Its success or failure will be determined by its rapid expansion, research advances, lack of standards, marketing enthusiasm, quality assurance, and regulations. Nutraceuticals have been used in different regions under different names/categories. however, globally there are no stringent pharmaceutical standards for nutraceutical health products till date, but slowly regulators are paying attention on it. Nutraceuticals can be broadly classified according to it clinical significance, source and therapeutic effects. Nutraceuticals and functional foods have grown to be a multibillion-dollar business worldwide in recent years and personalization is the emerging approach to deliver the best therapeutic effect in future. This review carries extensive information about nutraceutical history, classification, regulatory aspects and industrial perspective.
Acknowledgments
The authors would like to thank the Department of Science and Technology–fund for the improvement of science and technology infrastructure in Universities and Higher Educational Institutions (DST– FIST), New Delhi for their infrastructure support to our department.
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Research funding: Not applicable.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Not applicable.
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Ethical approval: Not applicable.
References
1. Yeung, AWK, Mocan, A, Atanasov, AG. Let food be thy medicine and medicine be thy food: a bibliometric analysis of the most cited papers focusing on nutraceuticals and functional foods. Food Chem 2018;269:455–65. https://doi.org/10.1016/j.foodchem.2018.06.139.Suche in Google Scholar PubMed
2. Wegener, G. Let food be thy medicine, and medicine be thy food: Hippocrates revisited. Acta Neuropsychiatr 2018;26:1–3. https://doi.org/10.1017/neu.2014.3.Suche in Google Scholar PubMed
3. Liu, Y, Qi, J, Luo, J, Wen, Q, Luo, Q, Zhang, Q, et al.. Okra in food field: nutritional value, health benefits and effects of processing methods on quality. Food Rev Int 2018;37:67–90.10.1080/87559129.2019.1695833Suche in Google Scholar
4. Tountas, Y. The historical origins of the basic concepts of health promotion and education: the role of ancient Greek philosophy and medicine. Health Promot Int 2009;24:185–92. https://doi.org/10.1093/heapro/dap006.Suche in Google Scholar PubMed
5. Touwaide, A, Appetiti, E. Food and medicines in the Mediterranean tradition. A systematic analysis of the earliest extant body of textual evidence. J Ethnopharmacol 2015;167:11–29. https://doi.org/10.1016/j.jep.2014.10.035.Suche in Google Scholar PubMed
6. Santini, A, Tenore, GC, Novellino, E. Nutraceuticals: a paradigm of proactive medicine. Eur J Pharmaceut Sci 2017;96:53–61. https://doi.org/10.1016/j.ejps.2016.09.003.Suche in Google Scholar PubMed
7. Ruth, A, Izzo, AA. Highlights into the pharmacology of nutraceuticals. Br J Pharmacol 2020;177:1209–11.10.1111/bph.15006Suche in Google Scholar PubMed PubMed Central
8. MisbahNazir, SA, Rao, SK, Nazir, W, Khalid, N, SajidMaqsood. Opportunities and challenges for functional and medicinal beverages: current and future trends. Trends Food Sci Technol 2019;88:513–26. https://doi.org/10.1016/j.tifs.2019.04.011.Suche in Google Scholar
9. Zhao, M, Chen, S, Ji, X, Shen, X, You, J, Liang, X, et al.. Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease. Pharmacol Res 2021;166:1043–6618. https://doi.org/10.1016/j.phrs.2021.105517.Suche in Google Scholar PubMed
10. Kumar, K, Kumar, S. Role of nutraceuticals in health and disease prevention: a review. South Asian J Food Technol Environ 2015;1:116–21. https://doi.org/10.46370/sajfte.2015.v01i02.02.Suche in Google Scholar
11. Nasri, H, Baradaran, A, Shirzad, H, Rafieian-Kopaei, M. New concepts in nutraceuticals as alternative for pharmaceuticals. Int J Prev Med 2014;5:1487–99.Suche in Google Scholar
12. Reimers, A, Hanna, L. The emerging role of omega-3 fatty acids as a therapeutic option in neuropsychiatric disorders. Ther Adv Respir Psychopharmacol 2019;9:2045125319858901.10.1177/2045125319858901Suche in Google Scholar PubMed PubMed Central
13. Jain, N, Ramawat, KG. Nutraceuticals and antioxidants in prevention of diseases. Natural Products 2013:2559–80. https://doi.org/10.1007/978-3-642-22144-6_70.Suche in Google Scholar
14. Santini, A, Cammarata, SM, Capone, G, Ianaro, A, Tenore, GC, Pani, L, et al.. Nutraceuticals: opening the debate for a regulatory framework. Br J Clin Pharmacol 2018. https://doi.org/10.1111/bcp.13496.Suche in Google Scholar PubMed PubMed Central
15. Durazzo, A, Lucarini, M, Santini, A. Nutraceuticals in human health. Foods 2020;9:370. https://doi.org/10.3390/foods9030370.Suche in Google Scholar PubMed PubMed Central
16. Singh, V, Mahaur, S, Kushwaha, SK. Nutraceuticals: a new golden era in health and disease. Asian J Res Chem 2018;11:652–8. https://doi.org/10.5958/0974-4150.2018.00117.7.Suche in Google Scholar
17. Crowe, KM. Position of the academy of nutrition and dietetics: functional foods. J Acad Nutr Diet 2013;12:1096–103. https://doi.org/10.1016/j.jand.2013.06.002.Suche in Google Scholar PubMed
18. Chauhan, B, Kumar, G, Kalam, N, Ansari, SH. Current concepts and prospects of herbal nutraceutical: a review. J Adv Pharm Technol Research 2013;4:4. https://doi.org/10.4103/2231-4040.107494.Suche in Google Scholar PubMed PubMed Central
19. DeFelice, SL. The nutraceutical revolution: its impact on food industry R&D. Trends Food Sci Technol 1995;6:59–61. https://doi.org/10.1016/s0924-2244(00)88944-x.Suche in Google Scholar
20. Gurung, N, Ray, S, Bose, S, Rai, V. A broader view: microbial enzymes and their relevance in industries, medicine, and beyond. BioMed Res Int 2013;2013:1–18.10.1155/2013/329121Suche in Google Scholar PubMed PubMed Central
21. Wallace, TC, Guarner, F, Madsen, K, Cabana, MD, Gibson, G, Hentges, E, et al.. Human gut microbiota and its relationship to health and disease. Nutr Rev 2009;69:392–403. https://doi.org/10.1111/j.1753-4887.2011.00402.x.Suche in Google Scholar PubMed
22. Alamgir, ANM Classification of drugs, nutraceuticals, functional food, and cosmeceuticals; proteins, peptides, and enzymes as drugs: therapeutic use of medicinal plants and their extracts. Cham: Springer; 2017, vol 1:125–75 pp. https://doi.org/10.1007/978-3-319-63862-1_5.Suche in Google Scholar
23. Douglas, LC, Sanders, ME. Probiotics and prebiotics in dietetics practice. J Am Diet Assoc 2008;108:510–21. https://doi.org/10.1016/j.jada.2007.12.009.Suche in Google Scholar PubMed
24. Maldonado, J, Cañabate, F, Sempere, L, Vela, F, Sánchez, AR, Narbona, E, et al.. Human milk probiotic Lactobacillus fermentum CECT5716 reduces the incidence of gastrointestinal and upper respiratory tract infections in infants. J Pediatr Gastroenterol Nutr 2012;54:55–61. https://doi.org/10.1097/mpg.0b013e3182333f18.Suche in Google Scholar PubMed
25. Ozen, M, Kocabas Sandal, G, Dinleyici, EC. Probiotics for the prevention of pediatric upper respiratory tract infections: a systematic review. Expert Opin Biol Ther 2015;15:9–20. https://doi.org/10.1517/14712598.2015.980233.Suche in Google Scholar PubMed
26. Strasser, B, Geiger, D, Schauer, M, Gostner, JM, Gatterer, H, Burtscher, M, et al.. Probiotic supplements beneficially affect tryptophan-kynurenine metabolism and reduce the incidence of upper respiratory tract infections in trained athletes: a randomized, double-blinded, placebo-controlled trial. Nutrients 2016;8. https://doi.org/10.3390/nu8110752.Suche in Google Scholar PubMed PubMed Central
27. Hor, YY, Lew, LC, Lau, ASY, Ong, JS, Chuah, LO, Lee, YY, et al.. Probiotic Lactobacillus casei Zhang (LCZ) alleviates respiratory, gastrointestinal & RBC abnormality via immuno-modulatory, anti-inflammatory & anti-oxidative actions. J Funct Foods 2018;44:235–45. https://doi.org/10.1016/j.jff.2018.03.017.Suche in Google Scholar
28. Kitazawa, H, Villena, J. Modulation of respiratory TLR3-anti-viral response by probiotic microorganisms: lessons learned from Lactobacillus rhamnosus CRL1505. Front Immunol 2014;5. https://doi.org/10.3389/fimmu.2014.00201.Suche in Google Scholar PubMed PubMed Central
29. Eguchi, K, Fujitani, N, Nakagawa, H, Miyazaki, T. Prevention of respiratory syncytial virus infection with probiotic lactic acid bacterium Lactobacillus gasseri SBT2055. Sci Rep 4812;9:2019. https://doi.org/10.1038/s41598-019-39602-7.Suche in Google Scholar PubMed PubMed Central
30. Aggarwal, BB, Prasad, S, Reuter, S, Kannappan, R, Yadev, VR, Park, B, et al.. Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases, reverse pharmacology and bedside to bench approach. Curr Drug Targets 2011;12:1595–653. https://doi.org/10.2174/138945011798109464.Suche in Google Scholar PubMed PubMed Central
31. Maheshwari, R, Kuche, KN, Advankar, A, Soni, N, Raval, N, Sharma, PA, et al., Natural ingredients/botanical extracts for the nutraceutical industry. Flavors for Nutraceutical and Functional Foods. CRC Press; 2018:5–122 pp. https://doi.org/10.1201/9781315160573-4.Suche in Google Scholar
32. Hussain, SA, Panjagari, NR, Singh, RRB, Patil, GR. Potential herbs and herbal nutraceuticals: food applications and their interactions with food components. Crit Rev Food Sci Nutr 2015;55:94–122. https://doi.org/10.1080/10408398.2011.64914.Suche in Google Scholar
33. Nwosu, OK, Ubaoji, KI. Nutraceuticals: history, classification and market demand. In: Egbuna, C, Dable Tupas, G, editors. Functional foods and nutraceuticals. Cham: Springer; 2020.10.1007/978-3-030-42319-3_2Suche in Google Scholar
34. Lai, WT, Khong, NM, Lim, SS, Hee, YY, Sim, BI, Lau, KY, et al.. A review: modified agricultural by-products for the development and fortification of food products and nutraceuticals. Trends Food Sci Technol 2017;59:148–60. https://doi.org/10.1016/j.tifs.2016.11.014.Suche in Google Scholar
35. Helal, NA, Eassa, HA, Amer, AM, Eltokhy, MA, Edafiogho, I, Nounou, MI. ‘Nutraceuticals’ novel formulations: the good, the bad, the unknown and patents involved. Recent Pat Drug Deliv Formulation 2019;13:105–56. https://doi.org/10.2174/1872211313666190503112040.Suche in Google Scholar PubMed PubMed Central
36. Gulati, OP, Berry Ottaway, P, Coppens, P. Botanical nutraceuticals, (food supplements, fortified and functional foods) in the european union with main focus on Nutrition and Health Claims Regulation Nutraceutical and Functional Food Regulations in the United States and Around the World. Academic Press; 2014:221–56 pp.10.1016/B978-0-12-405870-5.00014-1Suche in Google Scholar
37. Singh, B, Mal, G, Gautam, SK, Mukesh, M. Nutraceuticals from bioengineered microorganisms: advances in animal biotechnology. Cham: Springer; 2019:59–69 pp.10.1007/978-3-030-21309-1_6Suche in Google Scholar
38. Alasalvar, CFS, Peter, Q. Food and health applications of marine nutraceuticals: a review. Seafoods—Qual Technol Nutraceut Appl 2002:175–204. https://doi.org/10.1007/978-3-662-09836-3_15.Suche in Google Scholar
39. Suleria, HAR, Osborne, S, Masci, P, Gobe, G. Marine-based nutraceuticals: an innovative trend in the food and supplement industries. Mar Drugs 2015;13:6336–51. https://doi.org/10.3390/md13106336.Suche in Google Scholar PubMed PubMed Central
40. Kataki, MS, Rajkumari, A, Kakoti, BB. Functional foods and nutraceuticals: an overview of the clinical outcomes and evidence-based archive. Nanotechnology 2019:373–400. https://doi.org/10.1201/9781351111874-13.Suche in Google Scholar
41. Wang, J, Guleria, S, Koffas, MA, Yan, Y. Microbial production of value-added nutraceuticals. Curr Opin Biotechnol 2016;37:97–104. https://doi.org/10.1016/j.copbio.2015.11.003.Suche in Google Scholar PubMed
42. Aronson, JK. Defining ‘nutraceuticals’: neither nutritious nor pharmaceutical. Br J Clin Pharmacol 2017;83:8–19. https://doi.org/10.1111/bcp.12935.Suche in Google Scholar PubMed PubMed Central
43. Houston, MC. Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension. Prog Cardiovasc Dis 2005;47:396–449. https://doi.org/10.1016/j.pcad.2005.01.004.Suche in Google Scholar PubMed
44. Cornelli, U. Antioxidant use in nutraceuticals. Clin Dermatol 2009;27:175–94. https://doi.org/10.1016/j.clindermatol.2008.01.010.Suche in Google Scholar PubMed
45. Ostojic, SM. Mitochondria-targeted nutraceuticals in sports medicine: a new perspective. Res Sports Med 2017;25:91–100. https://doi.org/10.1080/15438627.2016.1258646.Suche in Google Scholar PubMed
46. Dutta, S, Ali, KM, Dash, SK, Giri, B. Role of nutraceuticals on health promotion and disease prevention: a review. J Drug Deliv Therapeut 2018;8:42–7. https://doi.org/10.22270/jddt.v8i4.1759.Suche in Google Scholar
47. Giang, J, Lan, X, Crichton, M, Marx, W, Marshall, S. Efficacy and safety of biophenol‐rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: a systematic literature review and meta‐analysis. Nutr Diet 2021;1–18. https://doi.org/10.1111/1747-0080.12672.Suche in Google Scholar PubMed PubMed Central
48. Gao, X, Liu, J, Li, L, Liu, W. A brief review of nutraceutical ingredients in gastrointestinal disorders: evidence and suggestions. Int J Mol Sci 2020;21:1822. https://doi.org/10.3390/ijms21051822.Suche in Google Scholar PubMed PubMed Central
49. Karn, AK, Giri, S, Bhatia, S, Singh, S, Singh, A, et al.. Nutraceuticals and their novel drug delivery system: a boon to human health. Curr Nutr Food Sci 2021;17:601–20. https://doi.org/10.2174/1573401316999201109212305.Suche in Google Scholar
50. Santos, HO, Scott, H, Teixeira, FJ. Beyond tribulus (Tribulusterrestris L.): the effects of phytotherapics on testosterone, sperm and prostate parameters. J Ethnopharmacol 2019;235:392–405. https://doi.org/10.1016/j.jep.2019.02.033.Suche in Google Scholar PubMed
51. Chu, M, Zheng, C, Chen, C, Song, G, Hu, X, Wang, ZW. Targeting cancer stem cells by nutraceuticals for cancer therapy Seminars in Cancer Biology. Academic Press; 2021, July.10.1016/j.semcancer.2021.07.008Suche in Google Scholar PubMed
52. Bickford, PC, Tan, J, Shytle, RD, Sanberg, CD, El-Badri, N, Sanberg, PR. Nutraceuticals synergistically promote proliferation of human stem cells. Stem Cell Dev 2006;15:118–23. https://doi.org/10.1089/scd.2006.15.118.Suche in Google Scholar PubMed
53. Davinelli, S, Scapagnini, G. Lifespan and healthspan extension by nutraceuticals: an overview. Centenarians 2019:169–79. https://doi.org/10.1007/978-3-030-20762-5_11.Suche in Google Scholar
54. Das, L, Bhaumik, E, Raychaudhuri, U, Chakraborty, R. Role of nutraceuticals in human health. J Food Sci Technol 2012;49:173–83. https://doi.org/10.1007/s13197-011-0269-4.Suche in Google Scholar PubMed PubMed Central
55. Alissa, EM, Ferns, GA. Functional foods and nutraceuticals in the primary prevention of cardiovascular diseases. J Nutr Metabol 2012;2012. https://doi.org/10.1155/2012/569486.Suche in Google Scholar PubMed PubMed Central
56. Arora, D, SundeepJaglan. Nanocarriers based delivery of nutraceuticals for cancer prevention and treatment: a review of recent research developments. Trends Food Sci Technol 2016;54:114–26. https://doi.org/10.1016/j.tifs.2016.06.003.Suche in Google Scholar
57. Park, EJ, Pezzuto, JM. Botanicals in cancer chemoprevention. Cancer Metastasis Rev 2002;21:231. https://doi.org/10.1023/a:1021254725842.10.1023/A:1021254725842Suche in Google Scholar
58. Antony, P, RanjitVijayan. Bioactive peptides as potential nutraceuticals for diabetes therapy: a comprehensive review. Int J Mol Sci 2021;22:9059. https://doi.org/10.3390/ijms22169059.Suche in Google Scholar PubMed PubMed Central
59. Tramontin, Ndos S, Luciano, TF, Marques, SD, de Souza, CT, Muller, AP. Ginger and avocado as nutraceuticals for obesity and its comorbidities. Phytother Res 2020;34:1282–90. https://doi.org/10.1002/ptr.6619.Suche in Google Scholar PubMed
60. Tingirikari, JMR. Functional foods for treatment and prevention of obesity and its associated disorders. Nutraceutical and Functional Foods in Disease Prevention. IGI Global 2019:93–124. https://doi.org/10.4018/978-1-5225-3267-5.ch004.Suche in Google Scholar
61. Akhtar, N, Haqqi, TM. Current nutraceuticals in the management of osteoarthritis: a review. Ther Adv Musculoskel Dis 2012;4:181–207. https://doi.org/10.1177/1759720x11436238.Suche in Google Scholar
62. Pandhi, S. Odontonutraceuticals: phytochemicals for oral health care Innovations in Food Technology. Singapore: Springer; 2020. p. 479–88.10.1007/978-981-15-6121-4_33Suche in Google Scholar
63. Uddin, MS, Al Mamun, A, Kabir, MT, Ahmad, J, Jeandet, P, Sarwar, MS, et al.. Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration. Eur J Pharmacol 2020;886:173412. https://doi.org/10.1016/j.ejphar.2020.173412.Suche in Google Scholar PubMed
64. Khan, A, Jahan, S, Alshahrani, S, Alshehri, BM, Sameer, AS, Arafah, A, et al.. Phytotherapeutic agents for neurodegenerative disorders: a neuropharmacological review Phytomedicine. Academic Press; 2021:581–620 pp. https://doi.org/10.1016/b978-0-12-824109-7.00012-1.Suche in Google Scholar
65. Sachdeva, V, Roy, A, Bharadvaja, N. Current prospects of nutraceuticals: a review. Curr Pharmaceut Biotechnol 2020;21:884–96. https://doi.org/10.2174/1389201021666200130113441.Suche in Google Scholar
66. Rossino, Grazia, M, Casini, G. Nutraceuticals for the treatment of diabetic retinopathy. Nutrients 2019;11:771. https://doi.org/10.3390/nu11040771.Suche in Google Scholar
67. Kaur, A, Gupta, V, Christopher, AF, Malik, MA, Bansal, P. Nutraceuticals in prevention of cataract–An evidence-based approach. Saudi J Ophthalmol 2017;31:30–7. https://doi.org/10.1016/j.sjopt.2016.12.001.Suche in Google Scholar
68. Liao, L-ying, He, YF, Li, L, Meng, H, Dong, YM, Yi, F, et al.. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med 2018;13:1–12. https://doi.org/10.1186/s13020-018-0214-9.Suche in Google Scholar
69. Pawar, VS, Hugar, S. A current status of adaptogens: natural remedy to stress. Asian Pac J Trop Dis 2012;2:S480–90. https://doi.org/10.1016/s2222-1808(12)60207-2.Suche in Google Scholar
70. Yeung, AWK, Souto, EB, Durazzo, A, Lucarini, M, Novellino, E, Tewari, D, et al.. Big impact of nanoparticles: analysis of the most cited nanopharmaceuticals and nanonutraceuticals research. Curr Res Biotechnol 2020;2:53–63. https://doi.org/10.1016/j.crbiot.2020.04.002.Suche in Google Scholar
71. Durazzo, A, Nazhand, A, Lucarini, M, Atanasov, AG, Souto, EB, Novellino, E, et al.. An updated overview on nanonutraceuticals: focus on nanoprebiotics and nanoprobiotics. Int J Mol Sci 2020;21:2285. https://doi.org/10.3390/ijms21072285.Suche in Google Scholar PubMed PubMed Central
72. Sauer, S, Plauth, A. Health-beneficial nutraceuticals—myth or reality? Appl Microbiol Biotechnol 2017;101:951–61. https://doi.org/10.1007/s00253-016-8068-5.Suche in Google Scholar PubMed
73. Espín, JC, García-Conesa, MT, Tomás-Barberán, FA. Nutraceuticals: facts and fiction. Phytochemistry 2007;68:22–4.10.1016/j.phytochem.2007.09.014Suche in Google Scholar PubMed
74. Kalra, EK. Nutraceutical-definition and introduction. AAPS Pharm Sci 2003;5:27–8. https://doi.org/10.1208/ps050325.Suche in Google Scholar PubMed PubMed Central
75. Gulati, K, Thokchom, SK, Joshi, JC, Ray, A. Regulatory guidelines for nutraceuticals in India: an overview. Nutraceuticals 2021;1273–80. https://doi.org/10.1016/b978-0-12-821038-3.00074-4.Suche in Google Scholar
76. https://fssai.gov.in/cms/health-supplements.php.Suche in Google Scholar
77. Jain, PN, Rathod, MH, Jain, CV, Vijayendraswamy, SM. Current regulatory requirements for registration of nutraceuticals in India and USA. Int J Drug Regul Affairs (IJDRA) 2018;6:22–9. https://doi.org/10.22270/ijdra.v6i2.232.Suche in Google Scholar
78. Giunta, R, Basile, G, Tibuzzi, A. Legislation on nutraceuticals and food supplements: a comparison between regulations in USA and EU Bio-Farms for Nutraceuticals. Boston, MA: Springer; 2010. p. 322–8. https://doi.org/10.1007/978-1-4419-7347-4_24.Suche in Google Scholar PubMed
79. Weaver, CM, Dwyer, J, Fulgoni III, VL, King, JC, Leveille, GA, MacDonald, RS, et al.. Processed foods: contributions to nutrition. Am J Clin Nutr 2014;99:1525–42. https://doi.org/10.3945/ajcn.114.089284.Suche in Google Scholar PubMed PubMed Central
80. European Commission Nutrition Claims. http://ec.europa.eu/food/safety/labelling_nutrition/claims/nutrition_claims/index_en.htm.Suche in Google Scholar
81. Health claim as per EFSA [European Commission Nutrition Claims]. http://ec.europa.eu/food/safety/labelling_nutrition/claims/nutrition_claims/index_en.htm.Suche in Google Scholar
82. Coppens, P, da Silva, MF, Pettman, S. European regulations on nutraceuticals, dietary supplements and functional foods. Framework Based Saf 2006;221:59–74. https://doi.org/10.1016/j.tox.2005.12.022.Suche in Google Scholar PubMed
83. Tedesco, DEA, Cagnardi, P. Regulatory Guidelines for Nutraceuticals in the European Union. In: Gupta, R, Srivastava, A, Lall, R, editors Nutraceuticals in Veterinary Medicine. Cham: Springer; 2019.10.1007/978-3-030-04624-8_58Suche in Google Scholar
84. Gulati, OP, Berry Ottaway, P. Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products 2006;221:75–87. https://doi.org/10.1016/j.tox.2006.01.014.Suche in Google Scholar PubMed
85. Hossain, F, Onyango, B. Product attributes and consumer acceptance of nutritionally enhanced genetically modified foods. Int J Consum Stud 2004;28:255–67. https://doi.org/10.1111/j.1470-6431.2004.00352.x.Suche in Google Scholar
86. Iwu, MM. Food as medicine: functional food plants of Africa. CRC Press; 2016.10.1201/9781315371627Suche in Google Scholar
87. Spindler, SR, Mote, PL, Flegal, JM. Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice 2014;36:705–18. https://doi.org/10.1007/s11357-013-9609-9.Suche in Google Scholar PubMed PubMed Central
88. https://www.netmeds.com/catalogsearch/result?q=nutritional%20supplement&in=Supplements.Suche in Google Scholar
89. Savant, S, Srinivasan, S, Kruthiventi, AK. Potential nutraceuticals for COVID-19. Nutr Diet Suppl 2021;13:25. https://doi.org/10.2147/nds.s294231.Suche in Google Scholar
90. Sikander, M, Malik, S, Rodriguez, A, Yallapu, MM, Narula, AS, Satapathy, SK. Role of nutraceuticals in COVID-19 mediated liver dysfunction. Molecules 2020;25:5905. https://doi.org/10.3390/molecules25245905.Suche in Google Scholar PubMed PubMed Central
91. Alesci, A, Aragona, M, Cicero, N, Lauriano, ER. Can nutraceuticals assist treatment and improve Covid-19 symptoms? Nat Prod Res 2021;1–20. https://doi.org/10.1080/14786419.2021.1914032.Suche in Google Scholar PubMed
92. Hu, FB, willett, WC. Optimal diet for prevention of coronary heart disease. J Am Med Assoc 2002;288:2569–78. https://doi.org/10.1001/jama.288.20.2569.Suche in Google Scholar PubMed
93. Livingstone, KM, Celis-Morales, C, Navas-Carretero, S, San-Cristobal, R, Forster, H. Personalised nutrition advice reduces intake of discretionary foods and beverages: findings from the Food4Me randomised controlled trial. Int J Behav Nutr Phys Activ 2021;18:70. https://doi.org/10.1186/s12966-021-01136-5.Suche in Google Scholar PubMed PubMed Central
94. Baturin, AK, EIu, S, Pogozheva, AV, Tutel’ian, VA. Genetic approaches to nutrition personalization. Voprosy pitaniia 2012;81:4–11.Suche in Google Scholar
95. Barsukova, N, Moskvicheva, E, Timoshenkova, I, Tsopa, E. Informational technologies and the prospects of personalization of food rations SHS Web of Conferences, vol 44. EDP Sciences; 2018.10.1051/shsconf/20184400014Suche in Google Scholar
96. Brug, J, Oenema, A, Campbell, M. Past, present, and future of computer-tailored nutrition education. Am J Clin Nutr 2003;77:1028S–34S. https://doi.org/10.1093/ajcn/77.4.1028s.Suche in Google Scholar PubMed
97. Celis-Morales, C, Livingstone, KM, Marsaux, CF, Macready, AL, Fallaize, R, O’Donovan, CB, et al.. Effect of personalized nutrition on health-related behaviour change: evidence from the Food4me European randomized controlled trial. Int J Epidemiol 2017;46:578–88. https://doi.org/10.1093/ije/dyw186.Suche in Google Scholar PubMed
98. Mendoza, RL. Cross-country experiences and lessons in nutraceutical health marketing in the United States, China, and India. Health Market Q 2020;37:281–99. https://doi.org/10.1080/07359683.2021.1947070.Suche in Google Scholar PubMed
99. Daliri, EB-M, Lee, BH. Current trends and future perspectives on functional foods and nutraceuticals. Cham: Beneficial Microorganisms in Food and Nutraceuticals: Springer; 2015:221–44 pp. https://doi.org/10.1007/978-3-319-23177-8_10.Suche in Google Scholar
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- Evidence implementation among complementary medicine practitioners: a meta-summary
- Phytochemical: a treatment option for heavy metal induced neurotoxicity
- The effects of curcumin-containing supplementations on inflammatory markers and lipid profiles in patients with chronic kidney diseases: a systematic review and meta-analysis of randomized controlled trials
- A systematic review on traditional medicinal Animal’s parts and products used for the treatment of respiratory tract disorders in Ethiopia
- Review on nutraceuticals: phase transition from preventive to protective care
- A study of effect of Centella asiatica on oxidative markers in the hippocampus of offsprings born to alcohol-fed pregnant rats and the correlation with their cognitive functions
- Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice
- Research Articles
- Comparison of antithyroid effects and hepatic complications of methimazole with catechin and its nanoencapsulation form in adult male rats
- Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism
- Highly efficient microencapsulation of phytonutrients by fractioned cellulose using biopolymer complexation technology
- Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model
- Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats
- Assessment of anti-inflammatory and antioxidant activity of quercetin–rutin blend (SophorOx™) – an invitro cell based assay
- Subchronic toxicological evaluation of EnXtra™ (standardised extract of Alpinia galanga rhizome) in rats
- Ficus glumosa Del. reduces phenylhydrazine-induced hemolytic anaemia and hepatic damage in Wistar rats
- Screening of anti-cancerous potential of classical Raudra rasa and modified Raudra rasa modified with hiraka bhasma (nanodiamond) through FTIR & LC-MS analysis
- Aqueous extract of Pedalium murex D. Royen ex L. leafy stem protects against lead induced testicular toxicity in Wistar rats
- Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze
- Developmental effects of early-life stress on dopamine D2 receptor and proteins involved in noncanonical D2 dopamine receptor signaling pathway in the prefrontal cortex of male rats
- Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei
- Acacia arabica (Lam.) Willd. On osteoblastogenesis, osteoblast proliferation, osteoclastic activity, and bone calcium mineralization
- GC-MS analysis of curculigo orchiodes and medicinal herbs with cytotoxic, hepatoprotective attributes of ethanolic extract from Indian origin
- Biochemical and histopathological evaluation of liver, kidney, and pancreas in normal Sprague Dawley rats administered aqueous extract of beetroot (Beta vulgaris)
- The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial
- The formulation and efficacy of topical Dorema ammoniacum in treating Melasma: a randomized double-blind, placebo-controlled trial
- Impact of inhalation aromatherapy with Damask Rose (Rosa damascena) on stress, anxiety and hemodynamic parameters of patients undergoing coronary angiography: a single blind randomized clinical trial
- Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silico analysis
- Prophylactic management of radiation-induced mucositis using herbal mouthwash in patients with head and neck cancer: an assessor-blinded randomized controlled trial
- Implementation science in New Zealand naturopathic practice: a cross-sectional study
- Issues of mindfulness implementation for oncology caregivers
- Immediate effect of cold mud pack therapy on autonomic variables in primary hypertensive individuals: a randomized trial
- Effect of a Persian metabolic diet on the functional dyspepsia symptoms in patients with postprandial distress syndrome: a randomized, double-blind clinical trial
Artikel in diesem Heft
- Frontmatter
- Reviews
- Evidence implementation among complementary medicine practitioners: a meta-summary
- Phytochemical: a treatment option for heavy metal induced neurotoxicity
- The effects of curcumin-containing supplementations on inflammatory markers and lipid profiles in patients with chronic kidney diseases: a systematic review and meta-analysis of randomized controlled trials
- A systematic review on traditional medicinal Animal’s parts and products used for the treatment of respiratory tract disorders in Ethiopia
- Review on nutraceuticals: phase transition from preventive to protective care
- A study of effect of Centella asiatica on oxidative markers in the hippocampus of offsprings born to alcohol-fed pregnant rats and the correlation with their cognitive functions
- Anxiogenic and anxiolytic effects of memantine injected into the ventral hippocampus in male stressed mice
- Research Articles
- Comparison of antithyroid effects and hepatic complications of methimazole with catechin and its nanoencapsulation form in adult male rats
- Almond oil restores blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism
- Highly efficient microencapsulation of phytonutrients by fractioned cellulose using biopolymer complexation technology
- Ocimum basilicum alleviates blood glucose, lipid profile and iNOS in diabetes gestational rat model
- Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats
- Assessment of anti-inflammatory and antioxidant activity of quercetin–rutin blend (SophorOx™) – an invitro cell based assay
- Subchronic toxicological evaluation of EnXtra™ (standardised extract of Alpinia galanga rhizome) in rats
- Ficus glumosa Del. reduces phenylhydrazine-induced hemolytic anaemia and hepatic damage in Wistar rats
- Screening of anti-cancerous potential of classical Raudra rasa and modified Raudra rasa modified with hiraka bhasma (nanodiamond) through FTIR & LC-MS analysis
- Aqueous extract of Pedalium murex D. Royen ex L. leafy stem protects against lead induced testicular toxicity in Wistar rats
- Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze
- Developmental effects of early-life stress on dopamine D2 receptor and proteins involved in noncanonical D2 dopamine receptor signaling pathway in the prefrontal cortex of male rats
- Probiotic administration enhanced antitrypanosomal effects of diminazene aceturate in dogs experimentally infected with Trypanosoma brucei brucei
- Acacia arabica (Lam.) Willd. On osteoblastogenesis, osteoblast proliferation, osteoclastic activity, and bone calcium mineralization
- GC-MS analysis of curculigo orchiodes and medicinal herbs with cytotoxic, hepatoprotective attributes of ethanolic extract from Indian origin
- Biochemical and histopathological evaluation of liver, kidney, and pancreas in normal Sprague Dawley rats administered aqueous extract of beetroot (Beta vulgaris)
- The effectiveness of emotional freedom techniques (EFT) on depression of postmenopausal women: a randomized controlled trial
- The formulation and efficacy of topical Dorema ammoniacum in treating Melasma: a randomized double-blind, placebo-controlled trial
- Impact of inhalation aromatherapy with Damask Rose (Rosa damascena) on stress, anxiety and hemodynamic parameters of patients undergoing coronary angiography: a single blind randomized clinical trial
- Hydro-alcoholic extract of Morus nigra reduces fasting blood glucose and HbA1c% in diabetic patients, probably via competitive and allosteric interaction with alpha-glucosidase enzyme; a clinical trial and in silico analysis
- Prophylactic management of radiation-induced mucositis using herbal mouthwash in patients with head and neck cancer: an assessor-blinded randomized controlled trial
- Implementation science in New Zealand naturopathic practice: a cross-sectional study
- Issues of mindfulness implementation for oncology caregivers
- Immediate effect of cold mud pack therapy on autonomic variables in primary hypertensive individuals: a randomized trial
- Effect of a Persian metabolic diet on the functional dyspepsia symptoms in patients with postprandial distress syndrome: a randomized, double-blind clinical trial