Muga (Antheraea assamensis) silk electrospun scaffold for biomedical applications
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Subramanian Sundaramoorthy
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Karthic Kumar Balan
Abstract
Wild silk varieties are less explored in the field of biomaterials than cultivated mulberry silk (Bombyx Mori). In the present work, an electrospun scaffold was produced from wild silk, muga (Antheraea assamensis), and it was assessed for the properties required for biomaterials. Scanning electron microscopy images showed that the electrospun fibers were formed without beads, and the majority of the fibers had diameters in the range of 500–900 nm. The scaffold started to decompose at 210 °C, which is higher than the temperature used for sterilization of the scaffold. The PBS uptake percentage was found to be 400 %, which is sufficient for the absorption of the medium used during cell culture. The scaffold had a hemolysis value of less than 5 %, which indicates that the scaffold exhibits good blood compatibility. The MTT assay showed cell viability of more than 80 % after 24 h and 48 h, and fluorescence microscopy showed that cells adhered and spread on the surface of the scaffold. The results show that muga silk electrospun mat can be used as an ideal biomaterial.
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Research ethics: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission. Contributon of authors: Subramanian Sundaramoorthy – Conceptualization, Design of experiment, interpretation of results, guidance in manuscript preparation Karthic KumarBalan – Interpretation of results, manuscript preparation Saravanan Ramaiyan Alwar – manuscript preparation Caraline I – Conducting experiment and analyzis Gowri S – Conducting experiment and analyzis Kavitha S – Conducting experiment and analyzis.
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Competing interests: The authors state no competing interests.
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Research funding: None declared.
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Data availability: Not applicable.
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Articles in the same Issue
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- News
- DGM – Deutsche Gesellschaft für Materialkunde
Articles in the same Issue
- Frontmatter
- Original Papers
- Polarizabilities and emission cross-sections of lanthanide laser crystals
- Wet-chemical synthesis and luminescence studies of nano-crystalline gadolinium gallium garnet
- Synthesis of carbon nanotube–iron oxide and silver nanocomposites as photocatalyst in removing carcinogenic aromatic dyes
- Influence of annealing temperature on the structure, morphology, optical property and antibacterial response of phytochemicals-assisted synthesized zinc oxide nanoparticles
- Study on the magnetic properties and critical behavior of CoFe2−xAl x O4 (x = 1.0 and 1.2) spinel ferrite
- Experimental study on selected properties and microstructure of pine-based wood ceramics
- Muga (Antheraea assamensis) silk electrospun scaffold for biomedical applications
- First-principles calculations of the mechanical properties of Mg2Si intermetallic via ternary elements doping
- Effects of Zr additions and process annealing on mechanical and corrosion properties of AA5383 Al–Mg alloys
- Study on the effect of LuCl3 doping on the characteristics of titanium alloy micro-arc oxidation coatings
- News
- DGM – Deutsche Gesellschaft für Materialkunde
