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Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome

  • Beatriz Alexandre-Santos ORCID logo , Felipe Figuerôa Tassinari Rocha Martins , Larissa da Silva Gonçalves , Clara de Oliveira Guimarães , Fernanda Carla-Ruggiero und D’Angelo Carlo Magliano ORCID logo EMAIL logo
Veröffentlicht/Copyright: 29. August 2022
Hormone Molecular Biology and Clinical Investigation
Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 44 Heft 1

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disorder that affects million women worldwide, presenting a complex pathophysiology that has not been fully elucidated yet. Recently, it has been suggested that PCOS triggers the endoplasmic reticulum (ER) stress, thus being associated with unfolded protein response (UPR) activation. Indeed, the UPR response has been associated with several pathological conditions, including in the reproductive system. Several studies demonstrated that ovarian UPR markers are upregulated in PCOS, being associated with worst ovarian outcomes, and this was ameliorated by ER stress inhibition. In this review, we aim to summarize the main findings from previous studies covering this topic, in an attempt to clarify the potential role of ER stress and the UPR response in the pathophysiology of PCOS.

Keywords: endoplasmic reticulum stress; polycystic ovary syndrome; unfolded protein response
Corresponding author: D’Angelo Carlo Magliano, Histology and Embryology League, Biomedical Institute, Fluminense Federal University, Niteroi, RJ, Brazil; and Research Center on Morphology and Metabolism, Department of Morphology, Biomedical Institute, Fluminense Federal University, Alameda Barros Terra, s/n, Sao Domingos, Niteroi, RJ CEP 24.020-150, Brazil, Phone/Fax: [+55 21] 2629-2405, E-mail:

Funding source: CNPq (Brazil Council for Scientific and Technological Development, www.cnpq.br)

Award Identifier / Grant number: 421753/2018-8 (DCM)

Funding source: FAPERJ (Rio de Janeiro State Foundation for Scientific Research, www.faperj.br)

Award Identifier / Grant number: JCNE E26/201.293/2022 (DCM)

Award Identifier / Grant number: E26/211.280/2019

Funding source: CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil)

Award Identifier / Grant number: Finance Code 001

  1. Research funding: This work was supported by the agencies CNPq (Brazil Council for Scientific and Technological Development, www.cnpq.br) [grant number 421753/2018-8, DCM]; FAPERJ (Rio de Janeiro State Foundation for Scientific Research, www.faperj.br) [grant number E26/211.280/2019 and JCNE E26/201.293/2022, DCM] and CAPES [Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil - Finance Code 001].

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Received: 2022-05-23
Accepted: 2022-08-07
Published Online: 2022-08-29

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Thyrotropin and body mass index, are they related?
  4. Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
  5. Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects
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  8. Comparative evaluation of INF-γ as an immunological healing marker based on anti-tubercular treatment among diabetic and non-diabetic pulmonary tuberculosis patients
  9. Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia
  10. Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis
  11. The effect of the ratio of serum progesterone level to oocyte count on the day of IVF-ICSI injection on pregnancy outcomes in HCG cycles
  12. Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
  13. Case Report
  14. Long-term complete remission of metastatic adrenocortical carcinoma
  15. Minireview
  16. Omicron variant of SARS-CoV-2: a review of existing literature
  17. Review Articles
  18. Modulatory role of prolactin in type 1 diabetes
  19. Omicron variant in COVID-19 current pandemic: a reason for apprehension
  20. COVID-19: a viewpoint from hepatic perspective
  21. Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
https://doi.org/10.1515/hmbci-2022-0051
Schlagwörter für diesen Artikel
endoplasmic reticulum stress; polycystic ovary syndrome; unfolded protein response

Artikel in diesem Heft

  1. Frontmatter
  2. Original Articles
  3. Thyrotropin and body mass index, are they related?
  4. Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
  5. Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects
  6. Decrease in serum asprosin levels following six weeks of spinning and stationary cycling training in overweight women
  7. Anti-proliferation effects of Apatinib in combination with Curcumin in breast cancer cells
  8. Comparative evaluation of INF-γ as an immunological healing marker based on anti-tubercular treatment among diabetic and non-diabetic pulmonary tuberculosis patients
  9. Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia
  10. Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis
  11. The effect of the ratio of serum progesterone level to oocyte count on the day of IVF-ICSI injection on pregnancy outcomes in HCG cycles
  12. Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
  13. Case Report
  14. Long-term complete remission of metastatic adrenocortical carcinoma
  15. Minireview
  16. Omicron variant of SARS-CoV-2: a review of existing literature
  17. Review Articles
  18. Modulatory role of prolactin in type 1 diabetes
  19. Omicron variant in COVID-19 current pandemic: a reason for apprehension
  20. COVID-19: a viewpoint from hepatic perspective
  21. Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
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