Thyrotropin and body mass index, are they related?
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Catarina R. Ivo
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Vitória Duarte
Abstract
Objectives
It is well recognized that overt thyroid dysfunction is associated with changes in body mass index (BMI). However, there is ongoing debate regarding the influence of thyroid stimulating hormone (TSH) on BMI, in euthyroid subjects. The aim of this study is to examine the association of TSH with BMI in an outpatient population without evidence of thyroid disease.
Methods
Cross-sectional study conducted in an Endocrinology Department. We identified the latest TSH and BMI measurements in 923 patients from the reference euthyroid population. All patients with positive thyroid autoimmunity and nodules were excluded. We performed a linear regression analysis using SPSSv.025.
Results
923 adult patients were evaluated. 79.4% were males, with a mean age of 67.6 years old. Mean TSH level was 1.78 mIU/L and mean BMI was 29.2 kg/m2. A significant negative correlation between serum TSH concentration and BMI was evident (p=0.04; r=−0.067). Statistical significance was lost when performing subgroup analysis, for males and females (p=0.19 and p=0.075), elderly (≥65 years) and non-elderly (p=0.55 and p=0.32) and also obese (BMI ≥30 kg/m2) and non-obese (p=0.39 and p=0.13).
Conclusions
The relationship between BMI and TSH is not consensual in the literature. This study included a large cohort sample of euthyroid patients, majority men and with negative autoimmunity. Our results support the hypothesis that variation in thyroid status within the normal range, could have a negative effect on BMI, contrary to most published studies.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The study complied with all the relevant national regulations and institutional policies and was performed in accordance with the tenets of the Helsinki Declaration, and has been approved by the Health Ethics Committee at Armed Forces Hospital.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Thyrotropin and body mass index, are they related?
- Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
- Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects
- Decrease in serum asprosin levels following six weeks of spinning and stationary cycling training in overweight women
- Anti-proliferation effects of Apatinib in combination with Curcumin in breast cancer cells
- Comparative evaluation of INF-γ as an immunological healing marker based on anti-tubercular treatment among diabetic and non-diabetic pulmonary tuberculosis patients
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- The effect of the ratio of serum progesterone level to oocyte count on the day of IVF-ICSI injection on pregnancy outcomes in HCG cycles
- Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
- Case Report
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- Minireview
- Omicron variant of SARS-CoV-2: a review of existing literature
- Review Articles
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Artikel in diesem Heft
- Frontmatter
- Original Articles
- Thyrotropin and body mass index, are they related?
- Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
- Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects
- Decrease in serum asprosin levels following six weeks of spinning and stationary cycling training in overweight women
- Anti-proliferation effects of Apatinib in combination with Curcumin in breast cancer cells
- Comparative evaluation of INF-γ as an immunological healing marker based on anti-tubercular treatment among diabetic and non-diabetic pulmonary tuberculosis patients
- Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia
- Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis
- The effect of the ratio of serum progesterone level to oocyte count on the day of IVF-ICSI injection on pregnancy outcomes in HCG cycles
- Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
- Case Report
- Long-term complete remission of metastatic adrenocortical carcinoma
- Minireview
- Omicron variant of SARS-CoV-2: a review of existing literature
- Review Articles
- Modulatory role of prolactin in type 1 diabetes
- Omicron variant in COVID-19 current pandemic: a reason for apprehension
- COVID-19: a viewpoint from hepatic perspective
- Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
