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Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects

  • Fatemeh Khaki-Khatibi , Behrouz Shademan , Reza Gholikhani-Darbroud EMAIL logo , Alireza Nourazarian EMAIL logo , Saeed Radagdam and Maghsoud Porzour
Published/Copyright: September 15, 2022
Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 44 Issue 1

Abstract

Objectives

Leptin polymorphism (LEP) has been associated with coronary heart disease (CAD), obesity, and high body mass index (BMI). However, we performed a systematic review and meta-analysis to discover the association because previous studies reached different conclusions.

Methods

Review Manager, version 5.3.5, and Stata, version 15.0, were used for statistical analysis. We calculated the effect size of the studies using the OR with the corresponding 95% CI, and two-sided (bilateral) p-values of 0.05 were considered significant. To determine heterogeneity among the selected studies, the Q test and I2 statistics were used. Meta-regression was used to examine the disease (heart disease, obesity, and high BMI) and heterogeneity between these subgroups.

Results

Eleven studies with 18,984 subjects were included in this study. The G-2548A (rs12112075), rs7799039, and A19G (rs2167270) polymorphisms of the leptin gene (but not the Lys656Asn (rs1805094) polymorphism) are associated with an increased risk of cardiovascular disease. Our pooled analysis revealed an association between the G-2548A (rs12112075) polymorphism and heart disease, high BMI, and obesity. This indicates that individuals carrying the AA allele are at an increased risk for heart disease, high BMI, and obesity. People with heart failure and coronary artery disease did not have the rs7799039 polymorphism or its alleles linked to them.

Conclusions

Combined analysis of data from current and published research suggests that the leptin gene polymorphisms G-2548A (rs12112075), rs7799039, and A19G (rs2167270) (but not the Lys656Asn (rs1805094) polymorphism) are associated with an increased risk of cardiovascular disease. Further research is needed to understand this association.

Keywords: body mass index; coronary artery disease; leptin; leptin receptor
Corresponding author: Dr. Reza Gholikhani-Darbroud, Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran; E-mail: ; and Dr. Alireza Nourazarian, Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran, E-mail:
Alireza Nourazarian and Reza Gholikhani-Darbroud contributed equally to this work.

  1. Research funding: This research received no specific grants from the public, commercial, or nonprofit funding agencies.

  2. Author contributions: FKH and RG write the draft. AN. Supervised the study and approved the draft manuscript. SR, BS and MP Data collection, draft writing.

  3. Competing interests: The authors declare there are no conflicts of interest.

  4. Ethical approval and consent to participate: Not applicable.

  5. Consent for publication: Not applicable.

  6. Availability of data and material: The data and materials used in this study are available.

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Received: 2022-02-14
Accepted: 2022-07-19
Published Online: 2022-09-15

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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  2. Original Articles
  3. Thyrotropin and body mass index, are they related?
  4. Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
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https://doi.org/10.1515/hmbci-2022-0020
Keywords for this article
body mass index; coronary artery disease; leptin; leptin receptor

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Thyrotropin and body mass index, are they related?
  4. Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
  5. Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects
  6. Decrease in serum asprosin levels following six weeks of spinning and stationary cycling training in overweight women
  7. Anti-proliferation effects of Apatinib in combination with Curcumin in breast cancer cells
  8. Comparative evaluation of INF-γ as an immunological healing marker based on anti-tubercular treatment among diabetic and non-diabetic pulmonary tuberculosis patients
  9. Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia
  10. Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis
  11. The effect of the ratio of serum progesterone level to oocyte count on the day of IVF-ICSI injection on pregnancy outcomes in HCG cycles
  12. Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
  13. Case Report
  14. Long-term complete remission of metastatic adrenocortical carcinoma
  15. Minireview
  16. Omicron variant of SARS-CoV-2: a review of existing literature
  17. Review Articles
  18. Modulatory role of prolactin in type 1 diabetes
  19. Omicron variant in COVID-19 current pandemic: a reason for apprehension
  20. COVID-19: a viewpoint from hepatic perspective
  21. Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
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