Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis

Kazem Cheragh Birjandi; Javad Sharafi; Ali Etemadizade; Elham Ghasemi

doi:10.1515/hmbci-2022-0027

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Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis

Kazem Cheragh Birjandi , Javad Sharafi , Ali Etemadizade und Elham Ghasemi

Veröffentlicht/Copyright: 30. August 2022

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Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 44 Heft 1

Abstract

Objectives

Immobility and its physiological and psychological consequences are common problems in patients with multiple sclerosis. The aim of this study was to investigate the effect of 8 weeks of combined training on Adipsin and lipid profile and the possible relationship between these indicators and psychological function in women with multiple sclerosis.

Methods

In this quasi-experimental study, 40 women with multiple sclerosis were selected by purposeful sampling method and randomly divided into two equal control and exercise groups (n=20). Exercise was performed for 8 weeks (two resistance sessions and one endurance session per week). Before and after the intervention, blood samples were taken and the DASS-21 questionnaire was completed to assess anxiety, depression and stress. Data were analyzed using analysis of covariance, t-test, Bonferroni post hoc test and Pearson correlation test at a significance level of p≤0.05.

Results

In the exercise group, levels of Adipsin, total cholesterol, LDL, TG, weight, fat percentage, WHR, BMI, depression, anxiety and stress were significantly reduced and HDL levels were significantly increased after 8 weeks of combined exercise (p≤0.05). Also, BMI (p=0.01), fat percentage (p=0.01) and WHR (p=0.01) levels had significant positive correlation with Adipsin. There was a significant positive relationship between Total cholesterol level with depression index (p=0.04).

Conclusions

Performing combination exercises through improving body composition can increase the risk of obesity and cardiovascular risk factors and improve the psychological function of patients with multiple sclerosis. Specialists can use these exercises as an adjunct to drug therapy for MS patients.

Keywords: adipsin; combined exercise; lipid profile; mental function; multiple sclerosis

Corresponding author: Dr. Kazem Cheragh Birjandi, Department of Physical Education, Birjand Branch, Islamic Azad University, Birjand, Iran, E-mail: kbirjandi@iaubir.ac.ir

Acknowledgement

The authors would like to thank Dr Asefi rad for his contribution and other individuals who participated in the study.

Research funding: The study supported by team and there was no external funding.
Author contributions: KCHB and EGH designed the study. KCHB, JSH, AE and EGH conducted data acquisition statistical analysis revising the draft approval of the final version of the manuscript. All authors revised and approved the manuscript.
Competing interests: The authors declare that they have no competing interests.
Ethics approval and consent to participate: The studies involving human participants were reviewed and approved by Ethical Standards in Research of the Ministry of Science, Research and Technology, with the code IR.SSRI.REC.1400.1331. The patients/participants provided their written informed consent to participate in this study.
Data availability: Derived data supporting the findings of this study are available upon reasonable request.

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Received: 2022-03-04

Accepted: 2022-07-20

Published Online: 2022-08-30

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Schlagwörter für diesen Artikel

adipsin; combined exercise; lipid profile; mental function; multiple sclerosis