Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
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Sanjiv Kumar Bansal
,
Varsha Suryan
,
Naveen Kumar Singh
Abstract
Objectives
The objective of this study is to estimate lipid parameters in subclinical hypothyroidism and correlate it with TSH.
Methods
Forty newly diagnosed cases of subclinical hypothyroidism and Forty age and gender-matched healthy controls were recruited for the study. Blood samples were collected from them and serum lipid profile (i.e. HDL, LDL, TG, serum total cholesterol) of the subjects was estimated by standard photometric methods in a fully auto-analyzer (MINDRAY BS-300) using commercially available kits and VLDL cholesterol was calculated using the Friedewald’s formula. While serum Ox-LDL, Lipoprotein A, Apolipoprotein A1 and Apo B were estimated by using commercial kit based on enzyme-linked immmunosorbent assay.
Results
The parameters such as Oxidized low-density lipoprotein (Ox-LDL), lipoprotein (a), apolipoprotein A1, apolipoprotein B and small dense lipoprotein (sd LDL) were significantly increased in subclinical hypothyroid cases when compared with the control subjects (p<0.0001). In present study results showed significant positive correlations of serum thyroid stimulating hormone (TSH) with Ox-LDL (r=0.85, p<0.01), sd LDL (r=0.71, p<0.01).
Conclusions
The present study focuses on the role of Ox-LDL, sd-LDL Lipoprotein A, Apolipoprotein A1 and Apo B that are sensitive indicators of atherogenic dyslipidemia in subclinical hypothyroidism and can serve as a better & novel risk factor for CAD.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
References
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Articles in the same Issue
- Frontmatter
- Original Articles
- Thyrotropin and body mass index, are they related?
- Does dexamethasone inhibit glucose oxidase: an analysis in kinetics and molecular study
- Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects
- Decrease in serum asprosin levels following six weeks of spinning and stationary cycling training in overweight women
- Anti-proliferation effects of Apatinib in combination with Curcumin in breast cancer cells
- Comparative evaluation of INF-γ as an immunological healing marker based on anti-tubercular treatment among diabetic and non-diabetic pulmonary tuberculosis patients
- Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia
- Influence of eight weeks of combined training on adipsin and lipoprotein profile and possible relations with depression, anxiety and stress in women with multiple sclerosis
- The effect of the ratio of serum progesterone level to oocyte count on the day of IVF-ICSI injection on pregnancy outcomes in HCG cycles
- Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism
- Case Report
- Long-term complete remission of metastatic adrenocortical carcinoma
- Minireview
- Omicron variant of SARS-CoV-2: a review of existing literature
- Review Articles
- Modulatory role of prolactin in type 1 diabetes
- Omicron variant in COVID-19 current pandemic: a reason for apprehension
- COVID-19: a viewpoint from hepatic perspective
- Potential role of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome
