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Preparation and properties of gelatin films incorporated with N-hydroxysuccinimide-activated end-bit binary acid

  • Chen Zhuang , Fu-Rong Tao EMAIL logo und Yue-Zhi Cui
Veröffentlicht/Copyright: 2. Februar 2016
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Abstract

A series of novel cross-linkers, N-hydroxysuccinimide (NHS)-activated end-bit binary acid (NHS- C4, C5, C6, C8, C10, C14), were synthesised to modify gelatin films and the crosslinking effects were compared. Homogeneous films with the exception of the film crosslinked by NHS-C14 were observed and the thickness was measured using a scanning electron microscope. The section feature influenced by different film-treatment conditions was also recorded. The differential scanning calorimetry results indicated higher thermal stability. The water contact angles confirmed enhanced hydrophobicity. NHS-C6, which was used as a probe crosslinker, exhibited the best crosslinking effect that the content of the free -NH2 achieved was the lowest out of all the crosslinkers. The biodegradation results of gelatin films modified by NHS-C6 exhibited better degradation-resistance and excellent stability. In addition, the optimal experimental conditions were 45°C for 12 h when [NHS-C6]/[-NH2] = 2.5.

Acknowledgements

The authors wish to express their gratitude for the financial support received from the promotive research fund for young and middle-aged scientists of Shandong Province (BS2014NJ012), the National Natural Science Foundation of China (no. 21276149) and the Programme for Scientific Research Innovation Team in Colleges and Universities of Shandong Province.

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Received: 2015-6-26
Revised: 2015-9-24
Accepted: 2015-10-3
Published Online: 2016-2-2
Published in Print: 2016-4-1

© 2015 Institute of Chemistry, Slovak Academy of Sciences

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