Abstract
A series of novel cross-linkers, N-hydroxysuccinimide (NHS)-activated end-bit binary acid (NHS- C4, C5, C6, C8, C10, C14), were synthesised to modify gelatin films and the crosslinking effects were compared. Homogeneous films with the exception of the film crosslinked by NHS-C14 were observed and the thickness was measured using a scanning electron microscope. The section feature influenced by different film-treatment conditions was also recorded. The differential scanning calorimetry results indicated higher thermal stability. The water contact angles confirmed enhanced hydrophobicity. NHS-C6, which was used as a probe crosslinker, exhibited the best crosslinking effect that the content of the free -NH2 achieved was the lowest out of all the crosslinkers. The biodegradation results of gelatin films modified by NHS-C6 exhibited better degradation-resistance and excellent stability. In addition, the optimal experimental conditions were 45°C for 12 h when [NHS-C6]/[-NH2] = 2.5.
Acknowledgements
The authors wish to express their gratitude for the financial support received from the promotive research fund for young and middle-aged scientists of Shandong Province (BS2014NJ012), the National Natural Science Foundation of China (no. 21276149) and the Programme for Scientific Research Innovation Team in Colleges and Universities of Shandong Province.
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© 2015 Institute of Chemistry, Slovak Academy of Sciences
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