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Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report
-
Teresa Sans
Veröffentlicht/Copyright:
1. Februar 2012
Abstract
Background: There is considerable interest in the research of molecules modulating the acute inflammatory response in patients with sepsis. Paraoxonases (PON) are antioxidant and anti-inflammatory enzymes that inhibit the production of the monocyte chemoattractant protein-1 (MCP-1). This preliminary study investigated changes in PON status and MCP-1 concentrations in critically ill patients with severe sepsis treated in an ICU and their relationship with the evolution of disease.
Methods: This was a longitudinal, prospective and observational study on 15 patients with sepsis, studied at baseline and on days 1, 2, 5, 7 and 10 of their stay in the ICU. In all the patients we measured serum PON1 and PON3 concentrations, PON1 paraoxonase and lactonase activities, serum MCP-1 concentrations, and several standard biochemical and haematological parameters.
Results: MCP-1 concentration significantly decreased with the resolution of sepsis, and this decrease was especially important during the first 5 days of hospitalisation. PON1 and PON3 tended to decrease during the first 5 days in ICU and significantly increased in days 7 and 10. Linear regression analysis showed significant and direct correlations among serum MCP-1 concentration and lactate levels at baseline. At the end of stay, PON1 paraoxonase and lactonase activities were significantly correlated with organ system function measurements.
Conclusions: We observed an inverse pattern between changes in MCP-1, and PON1 and PON3 levels in patients with sepsis, this was related to the resolution of their infection after receiving treatment in an ICU.
Received: 2011-12-2
Accepted: 2012-1-1
Published Online: 2012-02-01
Published in Print: 2012-08-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
intensive care;
monocyte chemoattractant protein-1;
paraoxonase;
sepsis
Artikel in diesem Heft
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- Effect of acceleration forces during transport through a pneumatic tube system on ROTEM® analysis
- The transferrin/log(ferritin) ratio: a new tool for the diagnosis of iron deficiency anemia
- Instructions on laboratory monitoring in 200 drug labels
- Lipid peroxidation markers in Crohn’s disease: the associations and diagnostic value
- Impact of asthmatic control status on serum cystatin C concentrations
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