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Association between ischemia-modified albumin, homocysteine, vitamin B12 and folic acid in patients with severe sepsis

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Veröffentlicht/Copyright: 14. Februar 2012
Clinical Chemistry and Laboratory Medicine
Aus der Zeitschrift Clinical Chemistry and Laboratory Medicine Band 50 Heft 8

Abstract

Background: The aim of the present study was to investigate serum ischemia-modified albumin (IMA), homocysteine, malondialdehyde (MDA), vitamin B12 and folic acid levels in patients with severe sepsis, compared to healthy control subjects. Also, we examined associations of these parameters with high-sensitivity C-reactive protein (hsCRP) in patients with severe sepsis and healthy control subjects.

Methods: This study was performed on 71 (40 male, 31 female) patients with severe sepsis aged 18–65 years and 70 (34 male, 36 female) healthy control subjects aged 18–65 years. Samples of patients were obtained at study entry within 24 h of onset of severe sepsis.

Results: Serum IMA, homocysteine and MDA levels of the patients with severe sepsis were significantly higher than those of the healthy control subjects (p<0.01 for IMA and homocysteine, and p<0.001 for MDA). There was no significant difference between serum vitamin B12and folic acid levels of the groups. Serum hsCRP levels were positively correlated with IMA (p<0.01) and MDA (p<0.01) in the patients with severe sepsis.

Conclusions: Our findings show that IMA may be useful as a prognostic biomarker because it can indicate the severity of illness in patients with sepsis.

Keywords: folic acid; homocysteine; ischemia-modified albumin; sepsis; vitamin B12
Corresponding author: Dr. Fatma Hümeyra Yerlikaya, PhD, Konya Universitesi, Karaciğan Mahallesi, Ankara Caddesi No: 74 Karatay, Konya, Turkey Phone: +90 0332-2351181, Fax: +90 0332-2362141
Received: 2011-10-30
Accepted: 2012-1-8
Published Online: 2012-02-14
Published in Print: 2012-08-01

©2012 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/cclm-2011-0794
Schlagwörter für diesen Artikel
folic acid; homocysteine; ischemia-modified albumin; sepsis; vitamin B12

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Editorial
  4. EDTA-dependent pseudothrombocytopenia: further insights and recommendations for prevention of a clinically threatening artifact
  5. Reviews
  6. Mitochondria as sources and targets of damage in cellular aging
  7. Application of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in Alzheimer’s disease
  8. Opinion Papers
  9. The intellectual contribution of laboratory medicine professionals to research papers on laboratory medicine topics published in high-impact general medicine journals
  10. Laboratory medicine and sports: between Scylla and Charybdis
  11. Guidelines and Recommendations
  12. The EC4 European Syllabus for Post-Graduate Training in Clinical Chemistry and Laboratory Medicine: version 4 – 2012
  13. Genetics And Molecular Diagnostics
  14. Assessing the utility of whole genome amplified DNA as a template for DMET Plus array
  15. General Clinical Chemistry And Laboratory Medicine
  16. Effect of acceleration forces during transport through a pneumatic tube system on ROTEM® analysis
  17. The transferrin/log(ferritin) ratio: a new tool for the diagnosis of iron deficiency anemia
  18. Instructions on laboratory monitoring in 200 drug labels
  19. Lipid peroxidation markers in Crohn’s disease: the associations and diagnostic value
  20. Impact of asthmatic control status on serum cystatin C concentrations
  21. Elevated levels of Nɛ-homocysteinyl-lysine isopeptide in patients on long-term hemodialysis
  22. Interleukin-1α gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people
  23. Novel method to dissociate platelet clumps in EDTA-dependent pseudothrombocytopenia based on the pathophysiological mechanism
  24. Proficiency testing/external quality assurance for the PFA-100®
  25. Interference of selected flavonoid aglycons in platelet aggregation assays
  26. Infectious Diseases
  27. Monocyte chemoattractant protein-1 and paraoxonase-1 and 3 levels in patients with sepsis treated in an intensive care unit: a preliminary report
  28. Association between ischemia-modified albumin, homocysteine, vitamin B12 and folic acid in patients with severe sepsis
  29. Evidence for serum miR-15a and miR-16 levels as biomarkers that distinguish sepsis from systemic inflammatory response syndrome in human subjects
  30. The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis
  31. Hypophosphatemia, fever and prolonged length of hospital stay in seronegative PCR positive patients as compared to seropositive patients with early acute Q fever pneumonia
  32. Cancer Diagnostics
  33. Diagnostic value of HE4 for ovarian cancer: a meta-analysis
  34. Cardiovascular Diseases
  35. Reactive oxygen metabolites (ROMs) are associated with cardiovascular disease in chronic hemodialysis patients
  36. Methylenetetrahydrofolate reductase C677T and reduced folate carrier 80 G>A polymorphisms are associated with an increased risk of conotruncal heart defects
  37. Oxidative stress as a predictor of cardiovascular events in coronary artery disease patients
  38. Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women
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  41. Measurement of glycated hemoglobin in a patient with homozygous hemoglobin E
  42. Congress Abstracts
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