Startseite Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond
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Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond

  • Catherine Gallou-Kabani , Alexandre Vigé , Marie-Sylvie Gross und Claudine Junien
Veröffentlicht/Copyright: 1. März 2007
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Clinical Chemistry and Laboratory Medicine (CCLM)
Aus der Zeitschrift Band 45 Heft 3

Abstract

The phenotype of an individual is the result of complex interactions between genotype, epigenome and current, past and ancestral environment, leading to lifelong remodelling of our epigenomes. Various replication-dependent and -independent epigenetic mechanisms are involved in developmental programming, lifelong stochastic and environmental deteriorations, circadian deteriorations, and transgenerational effects. Several types of sequences can be targets of a host of environmental factors and can be associated with specific epigenetic signatures and patterns of gene expression. Depending on the nature and intensity of the insult, the critical spatiotemporal windows and developmental or lifelong processes involved, these epigenetic alterations can lead to permanent changes in tissue and organ structure and function, or to reversible changes using appropriate epigenetic tools. Given several encouraging trials, prevention and therapy of age- and lifestyle-related diseases by individualised tailoring of optimal epigenetic diets or drugs are conceivable. However, these interventions will require intense efforts to unravel the complexity of these epigenetic, genetic and environment interactions and to evaluate their potential reversibility with minimal side effects.

Clin Chem Lab Med 2007;45:321–7.

Keywords: environment; epigenetics; fetal programming; metabolic syndrome; nutrition; transgenerational effects
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Corresponding author: Claudine Junien, Inserm Unit 781, Clinique Maurice Lamy, porte 15, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris, France Phone: +33-1-44494479, Fax: +33-1-47833206,

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Published Online: 2007-03-01
Published in Print: 2007-03-01

©2007 by Walter de Gruyter Berlin New York

Artikel in diesem Heft

  1. From human genetic variations to prediction of risks and responses to drugs and the environment
  2. Nutrigenomics – 2006 update
  3. How to comprehensively analyse proteins and how this influences nutritional research
  4. Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review
  5. The Gene-Diet Attica Investigation on childhood obesity (GENDAI): overview of the study design
  6. Polymorphisms in the APOA1/C3/A4/A5 gene cluster and cholesterol responsiveness to dietary change
  7. Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond
  8. Emerging role of cathepsin S in obesity and its associated diseases
  9. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population
  10. Multiplex polymerase chain reaction on FTA cards vs. flow cytometry for B-lymphocyte clonality
  11. Real-time multiplex PCR assay for genotyping of three apolipoprotein E alleles and two choline acetyltransferase alleles with three hybridization probes
  12. Immunomagnetic CD45 depletion does not improve cytokeratin 20 RT-PCR in colorectal cancer
  13. Analysis of the components of hypertransaminasemia after liver resection
  14. Fine characterization of mitral valve glycosaminoglycans and their modification with degenerative disease
  15. Oxidative stress evaluated using an automated method for hydroperoxide estimation in patients with coronary artery disease
  16. Secretory phospholipase A2 activity and release kinetics of vascular tissue remodelling biomarkers after coronary artery bypass grafting with and without cardiopulmonary bypass
  17. Clustered components of the metabolic syndrome and platelet counts in Japanese females
  18. International Standard for serum vitamin B12 and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B12 and folate content
  19. Multicentre physiological reference intervals for serum concentrations of immunoglobulins A, G and M, complement C3c and C4 measured with Tina-Quant® reagents systems
  20. In vivo and in vitro allergy diagnostics: it's time to reappraise the costs
  21. Experience with post-market surveillance of in-vitro diagnostic medical devices for lay use in Germany
  22. Evaluation of the high-sensitivity, full-range Olympus CRP OSR6199 application on the Olympus AU640®
  23. How to improve the teaching of urine microscopy
  24. In vitro determination of allergen-specific serum IgE. Comparative analysis of three methods
  25. Efficacy of a new blocker against anti-ruthenium antibody interference in the Elecsys free triiodothyronine assay
  26. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division Committee on Plasma Proteins (C-PP)
  27. Meeting Report: From human genetic variations to prediction of risks and responses to drugs and the environment
https://doi.org/10.1515/CCLM.2007.081
Schlagwörter für diesen Artikel
environment; epigenetics; fetal programming; metabolic syndrome; nutrition; transgenerational effects

Artikel in diesem Heft

  1. From human genetic variations to prediction of risks and responses to drugs and the environment
  2. Nutrigenomics – 2006 update
  3. How to comprehensively analyse proteins and how this influences nutritional research
  4. Genotypes, obesity and type 2 diabetes – can genetic information motivate weight loss? A review
  5. The Gene-Diet Attica Investigation on childhood obesity (GENDAI): overview of the study design
  6. Polymorphisms in the APOA1/C3/A4/A5 gene cluster and cholesterol responsiveness to dietary change
  7. Nutri-epigenomics: lifelong remodelling of our epigenomes by nutritional and metabolic factors and beyond
  8. Emerging role of cathepsin S in obesity and its associated diseases
  9. Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population
  10. Multiplex polymerase chain reaction on FTA cards vs. flow cytometry for B-lymphocyte clonality
  11. Real-time multiplex PCR assay for genotyping of three apolipoprotein E alleles and two choline acetyltransferase alleles with three hybridization probes
  12. Immunomagnetic CD45 depletion does not improve cytokeratin 20 RT-PCR in colorectal cancer
  13. Analysis of the components of hypertransaminasemia after liver resection
  14. Fine characterization of mitral valve glycosaminoglycans and their modification with degenerative disease
  15. Oxidative stress evaluated using an automated method for hydroperoxide estimation in patients with coronary artery disease
  16. Secretory phospholipase A2 activity and release kinetics of vascular tissue remodelling biomarkers after coronary artery bypass grafting with and without cardiopulmonary bypass
  17. Clustered components of the metabolic syndrome and platelet counts in Japanese females
  18. International Standard for serum vitamin B12 and serum folate: international collaborative study to evaluate a batch of lyophilised serum for B12 and folate content
  19. Multicentre physiological reference intervals for serum concentrations of immunoglobulins A, G and M, complement C3c and C4 measured with Tina-Quant® reagents systems
  20. In vivo and in vitro allergy diagnostics: it's time to reappraise the costs
  21. Experience with post-market surveillance of in-vitro diagnostic medical devices for lay use in Germany
  22. Evaluation of the high-sensitivity, full-range Olympus CRP OSR6199 application on the Olympus AU640®
  23. How to improve the teaching of urine microscopy
  24. In vitro determination of allergen-specific serum IgE. Comparative analysis of three methods
  25. Efficacy of a new blocker against anti-ruthenium antibody interference in the Elecsys free triiodothyronine assay
  26. Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition: International Federation of Clinical Chemistry and Laboratory Medicine (IFCC): IFCC Scientific Division Committee on Plasma Proteins (C-PP)
  27. Meeting Report: From human genetic variations to prediction of risks and responses to drugs and the environment
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