Ferrocenylmethylation of theophylline
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Daniel Weinem
Abstract
The sodium salt of theophylline is ferrocenylmethylated at N7 in water using [FcCH2NMe3]I. Further alkylation at N9 with various reagents and under different conditions was however unsuccessful. The molecular structures of both ferrocenylmethylated theophylline and sodium theophyllinate were determined by single crystal X-ray diffraction.
Dedicated to Professor Gerhard Müller on the occasion of his 70th birthday.
Acknowledgments
We gratefully acknowledge Siegfried PharmaChemikalien, Minden for a generous gift of sodium theophyllinate suspension.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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© 2022 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- In this issue
- Preface
- Professor Dr. Gerhard Müller. Editor-in-Chief der Zeitschrift für Naturforschung B – Chemical Sciences. zum 70. Geburtstag
- Research Articles
- Ferrocenylmethylation of theophylline
- Electron density of a cyclic tetrasaccharide composed of benzoylated galactose units
- Orthoamide und Iminiumsalze, CIX. Umsetzungen von Orthoamiden der Alkincarbonsäuren mit Diolen, Ethandithiol und CH-aciden Nitroverbindungen
- 1,4-Divinylphenylene-bridged diruthenium complexes with 2-hydroxypyridine- and 2- or 8-hydroxyquinoline-olate ligands
- The calcium oxidotellurates Ca2(TeIVTeVIO7), Ca2(TeIVO3)Cl2 and Ca5(TeIVO3)4Cl2 obtained from salt melts
- N-heterocyclic carbene-mediated oxidation of copper(I) in an imidazolium ionic liquid
- Synthesis, crystal structure, thermal and spectroscopic properties of ZnX2-2-methylpyrazine (X = Cl, Br, I) coordination compounds
- Solid-state molecular structures of Se(IV) and Te(IV) dihalides X2Se(CH3)(C6F5) and the gas-phase structure of Se(CH3)(C6F5)
- Ein neuartiger T-förmiger 14-Elektronen-Iridium(I)-Komplex stabilisiert durch eine agostische Ir–H-Wechselwirkung
- Exploring dicyanamides with two different alkali-metal cations: phase separations, solid solutions and the new compound Rb1.667Cs0.333[N(CN)2]2
- Eu4Al13Pt9 – a coloring variant of the Ho4Ir13Ge9 type structure
- Decoration of the [Nb6O19]8– cluster shell with six Cu2+-centred complexes generates the [(Cu(cyclen))6Nb6O19]4+ moiety: room temperature synthesis, crystal structure and selected properties
- Structure and spectroscopic properties of etherates of the beryllium halides
- The palladium-rich silicides RE3Pd20Si6 (RE = Sc, Y and Lu)
- Azido and desamino analogs of the marine natural product oroidin
- High-pressure high-temperature preparation of CeGe3
- On the synthesis and crystal structure of praseodymium(III) metaborate molybdate(VI) – PrBO2MoO4
- A third polymorph of the zwitterionic complex trichlorido-((dimethylphosphoryl)methanaminium-κO)zinc(II)
- Mechanochemical synthesis and structural evaluation of a metastable polymorph of Ti3Sn
- Synthesis and application of calcium silicate hydrate (C-S-H) nanoparticles for early strength enhancement by eco-friendly low carbon binders
- Sterically crowded di-indazolyl-pyridines: Iron(II) complexation studies
Articles in the same Issue
- Frontmatter
- In this issue
- Preface
- Professor Dr. Gerhard Müller. Editor-in-Chief der Zeitschrift für Naturforschung B – Chemical Sciences. zum 70. Geburtstag
- Research Articles
- Ferrocenylmethylation of theophylline
- Electron density of a cyclic tetrasaccharide composed of benzoylated galactose units
- Orthoamide und Iminiumsalze, CIX. Umsetzungen von Orthoamiden der Alkincarbonsäuren mit Diolen, Ethandithiol und CH-aciden Nitroverbindungen
- 1,4-Divinylphenylene-bridged diruthenium complexes with 2-hydroxypyridine- and 2- or 8-hydroxyquinoline-olate ligands
- The calcium oxidotellurates Ca2(TeIVTeVIO7), Ca2(TeIVO3)Cl2 and Ca5(TeIVO3)4Cl2 obtained from salt melts
- N-heterocyclic carbene-mediated oxidation of copper(I) in an imidazolium ionic liquid
- Synthesis, crystal structure, thermal and spectroscopic properties of ZnX2-2-methylpyrazine (X = Cl, Br, I) coordination compounds
- Solid-state molecular structures of Se(IV) and Te(IV) dihalides X2Se(CH3)(C6F5) and the gas-phase structure of Se(CH3)(C6F5)
- Ein neuartiger T-förmiger 14-Elektronen-Iridium(I)-Komplex stabilisiert durch eine agostische Ir–H-Wechselwirkung
- Exploring dicyanamides with two different alkali-metal cations: phase separations, solid solutions and the new compound Rb1.667Cs0.333[N(CN)2]2
- Eu4Al13Pt9 – a coloring variant of the Ho4Ir13Ge9 type structure
- Decoration of the [Nb6O19]8– cluster shell with six Cu2+-centred complexes generates the [(Cu(cyclen))6Nb6O19]4+ moiety: room temperature synthesis, crystal structure and selected properties
- Structure and spectroscopic properties of etherates of the beryllium halides
- The palladium-rich silicides RE3Pd20Si6 (RE = Sc, Y and Lu)
- Azido and desamino analogs of the marine natural product oroidin
- High-pressure high-temperature preparation of CeGe3
- On the synthesis and crystal structure of praseodymium(III) metaborate molybdate(VI) – PrBO2MoO4
- A third polymorph of the zwitterionic complex trichlorido-((dimethylphosphoryl)methanaminium-κO)zinc(II)
- Mechanochemical synthesis and structural evaluation of a metastable polymorph of Ti3Sn
- Synthesis and application of calcium silicate hydrate (C-S-H) nanoparticles for early strength enhancement by eco-friendly low carbon binders
- Sterically crowded di-indazolyl-pyridines: Iron(II) complexation studies
