Sensitive determination of nitrogenous hydrochloride drugs via their reaction with ammonium molybdate
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Suling Feng
und
Limin Guo
Abstract
In a hydrochloric acid medium, benzhexol hydrochloride, cyproheptadine hydrochloride, and maprotiline hydrochloride, can react with ammonium molybdate to form ion-association complexes by virtue of electrostatic attraction and hydrophobic interaction which result in a significant enhancement of the resonance light scattering intensity. The maximum scattering wavelengths were found at 364 nm, 364 nm, and 381 nm for benzhexol hydrochloride, cyproheptadine hydrochloride, and maprotiline hydrochloride systems, respectively. Spectral characteristics of the three systems, influencing factors, and optimum conditions were investigated. The reason of resonance light-scattering enhancement and the mechanism of interactions between the drugs and ammonium molybdate were also discussed. Based on the linear relationship between the enhanced intensity of resonance light scattering and the concentration of drugs, a highly sensitive method for the determination of the three drugs was developed, the detection limits being 0.0110 μmol L−1, 0.0038 μmol L−1, and 0.0155 μmol L−1 for benzhexol hydrochloride, cyproheptadine hydrochloride, and maprotiline hydrochloride, respectively. The method was successfully applied to the determination of the investigated drugs in pharmaceutical, serum, and urine samples.
[1] Anglister, J., & Steinberg, I. Z. (1983). Resonance Rayleigh scattering of cyanine dyes in solution. The Journal of Chemical Physics, 78, 5358–5368. DOI: 10.1063/1.445489. http://dx.doi.org/10.1063/1.44548910.1063/1.445489Suche in Google Scholar
[2] Anglister, J., & Steinberg, I. Z. (1979). Depolarized Rayleigh light scattering in absorption bands measured in lycopene solution. Chemical Physics Letters, 65, 50–54. DOI: 10.1016/0009-2614(79)80123-2. http://dx.doi.org/10.1016/0009-2614(79)80123-210.1016/0009-2614(79)80123-2Suche in Google Scholar
[3] Cui, F. L., Wang, L., & Cui, Y. R. (2007). Determination of bismuth in pharmaceutical products using methyltriphenylphosphonium bromide as a molecular probe by resonance light scattering technique. Journal of Pharmaceutical and Biomedical Analysis, 43, 1033–1038. DOI: 10.1016/j.jpba.2006.10.003. http://dx.doi.org/10.1016/j.jpba.2006.10.00310.1016/j.jpba.2006.10.003Suche in Google Scholar
[4] Drozd, J., & Hopkala, H. (2004). Cyproheptadine ion-selective electrodes and their applications in some pharmaceutical formulations. Desalination, 163, 119–125. DOI: 10.1016/S0011-9164(04)90183-X. http://dx.doi.org/10.1016/S0011-9164(04)90183-X10.1016/S0011-9164(04)90183-XSuche in Google Scholar
[5] El-Gindy, A., El-Yazby, F., Mostafa, A., & Maher, M.M. (2004). HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid. Journal of Pharmaceutical and Biomedical Analysis, 35, 703–713. DOI: 10.1016/j.jpba.2004.02.027. http://dx.doi.org/10.1016/j.jpba.2004.02.02710.1016/j.jpba.2004.02.027Suche in Google Scholar
[6] Feng, S. L., Pan, Z. H., & Fan, J. (2005). Determination of trace proteins with pyronine Y and SDS by resonance light scattering. Analytical and Bioanalytical Chemistry, 383, 255–260. DOI: 10.1007/s00216-005-3402-2. http://dx.doi.org/10.1007/s00216-005-3402-210.1007/s00216-005-3402-2Suche in Google Scholar
[7] Feng, S. L., Pan, Z. H., & Fan, J. (2006). Determination of proteins at nanogram levels with Bordeaux red based on the enhancement of resonance light scattering. Spectrochimica Acta A, 64, 574–579. DOI: 10.1016/j.saa.2005.07.056. http://dx.doi.org/10.1016/j.saa.2005.07.05610.1016/j.saa.2005.07.056Suche in Google Scholar
[8] Gu, Y. D., Xie, G. Y., Song, Y., & Jin, S. L. (1998). Group chromium. In P. W. Shen, Y. X. Che, Y. J. Luo, Y. D. Gu, G. Y. Xie, Y. Song, & S. L. Jin (Eds.), Inorganic Chemistry Series (pp. 391–591). Beijing: Science Press. Suche in Google Scholar
[9] Jia, Z., Yang, J. H., Wu, X., Sun, C. X., Liu, S. F., Wang, F., & Zhao, Z. S. (2006). The sensitive determination of nucleic acids using resonance light scattering quenching method. Spectrochimica Acta A, 64, 555–559. DOI: 10.1016/j.saa.2005.07.052. http://dx.doi.org/10.1016/j.saa.2005.07.05210.1016/j.saa.2005.07.052Suche in Google Scholar
[10] Leung, C. P. (1980). Determination of benzhexol hydrochloride in tablets by high-performance liquid chromatography. Analytica Chimica Acta, 118, 373–376. DOI: 10.1016/S0003-2670(01)93614-1. http://dx.doi.org/10.1016/S0003-2670(01)93614-110.1016/S0003-2670(01)93614-1Suche in Google Scholar
[11] Li, M., Ahuja, E. S., & Watkins, D. M. (2003). LC-MS and NMR determination of a dichloromethane artifact adduct, cyproheptadine chloromethochloride. Journal of Pharmaceutical and Biomedical Analysis, 31, 29–38. DOI: 10.1016/S0731-7085(02) 00599-X. http://dx.doi.org/10.1016/S0731-7085(02)00599-X10.1016/S0731-7085(02)00599-XSuche in Google Scholar
[12] Liu, S. P., Liu, Z. F., & Luo, H. Q. (2000). Resonance Rayleigh scattering method for the determination of trace amounts of cadmium with iodide-rhodamine dye systems. Analytica Chimica Acta, 407, 255–260. DOI: 10.1016/S0003-2670(99)00816-8. http://dx.doi.org/10.1016/S0003-2670(99)00816-810.1016/S0003-2670(99)00816-8Suche in Google Scholar
[13] Liu, Y. M., & Li, G. Z. (2001). Indirect determination of benzhexol in tablets by inductively coupled plasma-atomic emission spectroscopy. Chinese Journal of Analytical Chemistry, 29, 66–69. Suche in Google Scholar
[14] Ma, C. K., Mok, C. S., & Hon, P. K. (1995). Determination of benzhexol hydrochloride and ethambutol hydrochloride tablets by liquid chromatography. Analytica Chimica Acta, 314, 77–85. DOI: 10.1016/0003-2670(95)00264-Z. http://dx.doi.org/10.1016/0003-2670(95)00264-Z10.1016/0003-2670(95)00264-ZSuche in Google Scholar
[15] Miao, A. D., & Wang, B. F. (2001). Determination of cyproheptadine hydrochloride with reversed-phase high performance liquid chromatgraphy. Chinese Journal of Analytical Chemistry, 21, 60–61. Suche in Google Scholar
[16] The Pharmacopoeia Committee of the People’s Republic of China. (2005). The Pharmacopoeia of the People’s Republic of China (2nd ed). Beijing: Chemical Industry Press. Suche in Google Scholar
[17] Wang, F., Yang, J. H., Wu, X., Wang, F., & Ding, H. H. (2007). Investigation of the interaction between curcumin and nucleic acid in the presence of CTAB. Spectrochimica Acta A, 67, 385–390. DOI: 10.1016/j.saa.2006.07.027. http://dx.doi.org/10.1016/j.saa.2006.07.02710.1016/j.saa.2006.07.027Suche in Google Scholar PubMed
[18] Xiao, J. B., Chen, J. W., Ren, F. L., Yang, C. S., & Xu, M. (2007). Use of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide for rapid detection of methicillinresistant staphylococcus aureus by resonance light scattering. Analytica Chimica Acta, 589, 186–191. DOI: 10.1016/j.aca.2007.02.073. http://dx.doi.org/10.1016/j.aca.2007.02.07310.1016/j.aca.2007.02.073Suche in Google Scholar PubMed
[19] Yan, J. L., Liu, J. F., Cao, W. D., Sun, X. H., Yang, X. R., & Wang, E. K. (2004). Determination of benzhexol hydrochloride by capillary zone electrophoresis with an end-column electrochemiluminescence detection. Microchemical Journal, 76, 11–16. DOI: 10.1016/j.microc.2003.10.003. http://dx.doi.org/10.1016/j.microc.2003.10.00310.1016/j.microc.2003.10.003Suche in Google Scholar
[20] Yang, C. X., Li, Y. F., & Huang, C. Z. (2002). Determination of cationic surfactants in water samples by their enhanced resonance light scattering with azoviolet. Analytical and Bioanalytical Chemistry, 374, 868–872. DOI: 10.1007/s00216-002-1527-0. http://dx.doi.org/10.1007/s00216-002-1527-010.1007/s00216-002-1527-0Suche in Google Scholar PubMed
© 2008 Institute of Chemistry, Slovak Academy of Sciences
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Artikel in diesem Heft
- Square-wave adsorptive stripping voltammetric determination of an antihistamine drug astemizole
- Flow injection spectrophotometric determination of iron(III) using diphenylamine-4-sulfonic acid sodium salt
- Sensitive determination of nitrogenous hydrochloride drugs via their reaction with ammonium molybdate
- Effect of different Fe(III) compounds on photosynthetic electron transport in spinach chloroplasts and on iron accumulation in maize plants
- Comparison of different technologies for alginate beads production
- Design and economics of industrial production of fructooligosaccharides
- Preparation of nanocrystalline anatase TiO2 using basic sol-gel method
- 3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazole based ligands — protonation and metal complex formation
- Synthesis, characterization, fluorescence and redox features of new vic-dioxime ligand bearing pyrene and its metal complexes
- Synthesis and characterization of diaminomaleonitrile-functionalized polystyrene grafts for application in pervaporation separation
- Synthesis and magnetic properties of polymeric complexes containing ruthenium(II)-ruthenium(III) tetracarboxylato units linked by cyanato, thiocyanato, and selenocyanato ligands
- Preparation and modification of collagen-based porous scaffold for tissue engineering
- Synthesis, crystal structure, and magnetic properties of a cobalt(II) complex with (3,5-dichloropyridin-4-yl)(pyridin-4-yl)methanol
- Synthesis and reactions of 2-[3-(trifluoromethyl)phenyl]furo[3,2-c]pyridine
- Alkalimetric determination of hydrophobic pharmaceuticals using stabilized o/w emulsions
- Extraction and analysis of ellagic acid from novel complex sources
