Startseite Naturwissenschaften 68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications
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68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

  • Yousef Fazaeli EMAIL logo , Mohammad Amin Hosseini , Mohammadreza Afrasyabi und Parviz Ashtari
Veröffentlicht/Copyright: 29. September 2018
Radiochimica Acta
Aus der Zeitschrift Radiochimica Acta Band 107 Heft 2

Abstract

Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68Ga]-Py-Butyl@MCM-41, was done in Fibrosarcoma tumor-bearing mice. This labeled nanocomposite with appropriate blood circulation in body, high structural stability, high tumor/blood ID/g% ratio and fast excretion from the body can be proposed as an efficient nano engineered composite for upcoming tumor targeting/imaging nanotechnology-based applications.

Keywords: MCM-41; 68Ga; PET; diagnostic agent; drug delivery

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Received: 2017-12-20
Accepted: 2018-09-04
Published Online: 2018-09-29
Published in Print: 2019-02-25

©2019 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Electrochemical and thermodynamic properties of U4+ and U3+ on Mo electrode in LiCl-KCl eutectic
  3. Speciation of technetium in carbonate media under helium ions and γ radiation
  4. Effect of sulfate on sorption of Eu(III) by Na-montmorillonite
  5. Effect of grain size on radon emanation coefficient, surface and mass exhalation rates and the correlation coefficient between them in different masses of soil and phosphate fertilizer
  6. Ratio primary reference measurement procedure (RPRMP) for the certification of chromium content in biological reference materials
  7. Photon activation analysis of sand samples from Antalya in Turkey with a clinical electron linear accelerator
  8. 68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications
  9. Kinetics of nonisothermal dehydration of unirradiated and γ-ray irradiated neodymium (III) acetate hydrate
  10. Investigation of radiation shielding properties for some ceramics
https://doi.org/10.1515/ract-2017-2923
Schlagwörter für diesen Artikel
MCM-41; 68Ga; PET; diagnostic agent; drug delivery

Artikel in diesem Heft

  1. Frontmatter
  2. Electrochemical and thermodynamic properties of U4+ and U3+ on Mo electrode in LiCl-KCl eutectic
  3. Speciation of technetium in carbonate media under helium ions and γ radiation
  4. Effect of sulfate on sorption of Eu(III) by Na-montmorillonite
  5. Effect of grain size on radon emanation coefficient, surface and mass exhalation rates and the correlation coefficient between them in different masses of soil and phosphate fertilizer
  6. Ratio primary reference measurement procedure (RPRMP) for the certification of chromium content in biological reference materials
  7. Photon activation analysis of sand samples from Antalya in Turkey with a clinical electron linear accelerator
  8. 68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications
  9. Kinetics of nonisothermal dehydration of unirradiated and γ-ray irradiated neodymium (III) acetate hydrate
  10. Investigation of radiation shielding properties for some ceramics
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