68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

Yousef Fazaeli; Mohammad Amin Hosseini; Mohammadreza Afrasyabi; Parviz Ashtari

doi:10.1515/ract-2017-2923

Article

⁶⁸Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

Yousef Fazaeli , Mohammad Amin Hosseini , Mohammadreza Afrasyabi and Parviz Ashtari

Published/Copyright: September 29, 2018

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From the journal Radiochimica Acta Volume 107 Issue 2

Abstract

Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [⁶⁸Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [⁶⁸Ga]-Py-Butyl@MCM-41, was done in Fibrosarcoma tumor-bearing mice. This labeled nanocomposite with appropriate blood circulation in body, high structural stability, high tumor/blood ID/g% ratio and fast excretion from the body can be proposed as an efficient nano engineered composite for upcoming tumor targeting/imaging nanotechnology-based applications.

Keywords: MCM-41; 68Ga; PET; diagnostic agent; drug delivery

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Received: 2017-12-20

Accepted: 2018-09-04

Published Online: 2018-09-29

Published in Print: 2019-02-25

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Keywords for this article

MCM-41; 68Ga; PET; diagnostic agent; drug delivery