Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
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Carla Estaquio
Abstract
Background: The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT4) based on data collected from a disease-free sample of French middle-aged adults.
Methods: A total of 3218 subjects participating in the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) study had measurements for TSH, fT4 and urinary iodine concentrations. Thyroid volume and structure were evaluated using standardized ultrasonography. We selected a disease-free sample which included 2338 subjects (1313 females aged 35–60 years and 1025 males aged 45–60 years) with normal thyroid imaging, no previously reported thyroid disease or use of thyroid medication, and no risk factors for thyroid dysfunction. Distribution of TSH and fT4 was estimated in males and females.
Results: The median (central 95% range) TSH serum concentrations for females were 1.79 mU/L (0.29–5.21 mU/L) for ages 35–44 years and 1.98 mU/L (0.27–6.94 mU/L) for ages 45–60 years (p<0.0001, for age). The median (central 95% range) for males 45–60-year-old was 1.63 mU/L (0.28–4.54 mU/L) (p<0.0001, for sex). Sex- and age-specific mean fT4 concentrations did not differ significantly (p=0.06) between males and females and (p=0.08) between female age groups. However, median fT4 concentrations between 45–60-year-old males and females differed (p<0.001).
Conclusions: In middle-aged adults, the TSH distribution was associated with gender and, among females, with age. Stratification according to gender and age should be considered when TSH ranges are used in the diagnosis, treatment and monitoring of thyroid disease.
Clin Chem Lab Med 2009;47:1497–505.
©2009 by Walter de Gruyter Berlin New York
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- Letters to the Editor
- Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
- Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
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- Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
- The impact factor for evaluating scientists: the good, the bad and the ugly
- Acknowledgement
- Acknowledgement
- Contents
- Contents, Volume 47, 2009
- Author Index
- Author Index
- Subject Index
- Subject Index
Artikel in diesem Heft
- Review
- Multiple gene interaction and modulation of hemostatic balance
- Minireview
- Appropriate utilization of clinical laboratory tests
- Genetics and Molecular Diagnostics
- Quantitation of RNA decay in dried blood spots during 20 years of storage
- ROS1 Asp2213Asn polymorphism is not associated with coronary artery disease in a Greek case-control study
- Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children
- Haplotype-based association of regulator of G-protein signaling 5 gene polymorphisms with essential hypertension and metabolic parameters in Chinese
- A new automated human leukocyte antigen genotyping strategy to identify DR-DQ risk alleles for celiac disease and type 1 diabetes mellitus
- General Clinical Chemistry and Laboratory Medicine
- Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
- Screening for M-proteinemia: serum protein electrophoresis and free light chains compared
- Temporal profile and clinical significance of serum neuron-specific enolase and S100 in ischemic and hemorrhagic stroke
- Salivary neuron specific enolase: an indicator for neuronal damage in patients with ischemic stroke and stroke-prone patients
- Antibodies to mutated citrullinated vimentin and antibodies to cyclic citrullinated peptides in juvenile idiopathic arthritis
- Age-associated developmental changes in the activated partial thromboplastin time (APTT) and causes of prolonged APTT values in healthy Chinese children
- Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis
- Serum chitotriosidase enzyme activity in patients with Crimean-Congo hemorrhagic fever
- Preanalytical mistakes in samples from primary care patients
- Should kidney tubular markers be adjusted for urine creatinine? The example of urinary cystatin C
- Validation and Outcome Studies
- Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP)
- Development and validation of a liquid chromatography-tandem mass spectrometry assay for serum 25-hydroxyvitamin D2/D3 using a turbulent flow online extraction technology
- Letters to the Editor
- Lack of association between eNOS Glu298Asp gene polymorphism and carotid atherosclerosis in a Serbian population
- Falsely elevated troponin I attributed to collection tubes using the Vitros ECiQ system
- Processing effects and storage conditions on A Disintegrin And Metalloprotease (ADAM12s), a maternal serum marker for adverse pregnancy outcome
- Serum γ-glutamyltransferase: linking together environmental pollution, redox equilibria and progression of atherosclerosis?
- The impact factor for evaluating scientists: the good, the bad and the ugly
- Acknowledgement
- Acknowledgement
- Contents
- Contents, Volume 47, 2009
- Author Index
- Author Index
- Subject Index
- Subject Index
